Reaction mechanism of hydroxynitrile lyases of the alpha/beta-hydrolase superfamily: the three-dimensional structure of the transient enzyme-substrate complex certifies the crucial role of LYS236.
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Atomic resolution crystal structures and quantum chemistry meet to reveal subtleties of hydroxynitrile lyase catalysisSubstrate Binding in the FAD-Dependent Hydroxynitrile Lyase from Almond Provides Insight into the Mechanism of Cyanohydrin Formation and Explains the Absence of Dehydrogenation Activity † , ‡Characterization of a Carbon-Carbon Hydrolase from Mycobacterium tuberculosis Involved in Cholesterol MetabolismStructural basis for cofactor-independent dioxygenation of N-heteroaromatic compounds at the / -hydrolase foldSwitching Catalysis from Hydrolysis to Perhydrolysis in Pseudomonas fluorescens Esterase ,Hydroxynitrile Lyases with α/β-Hydrolase Fold: Two Enzymes with Almost Identical 3D Structures but Opposite Enantioselectivities and Different Reaction MechanismsEmergent Decarboxylase Activity and Attenuation of α/β-Hydrolase Activity during the Evolution of Methylketone Biosynthesis in TomatoBiochemical and structural characterization of a novel bacterial manganese-dependent hydroxynitrile lyaseHow the Same Core Catalytic Machinery Catalyzes 17 Different Reactions: the Serine-Histidine-Aspartate Catalytic Triad of α/β-Hydrolase Fold Enzymes.Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity.Increasing the reaction rate of hydroxynitrile lyase from Hevea brasiliensis toward mandelonitrile by copying active site residues from an esterase that accepts aromatic esters.Comparative Bioinformatic Analysis of Active Site Structures in Evolutionarily Remote Homologues of α,β-Hydrolase Superfamily EnzymesUncovering divergent evolution of α/β-hydrolases: a surprising residue substitution needed to convert Hevea brasiliensis hydroxynitrile lyase into an esteraseEvolution of a Catalytic Mechanism.Protein engineering of α/β-hydrolase fold enzymes.The impact of structural biology on alkaloid biosynthesis research.Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom.Xylella fastidiosa esterase rather than hydroxynitrile lyase.Activity and enantioselectivity of the hydroxynitrile lyase MeHNL in dry organic solvents.Catalytic Promiscuity of Ancestral Esterases and Hydroxynitrile Lyases.Protein evolution analysis of S-hydroxynitrile lyase by complete sequence design utilizing the INTMSAlign software.New insights into acetone metabolism.An R-selective hydroxynitrile lyase from Arabidopsis thaliana with an alpha/beta-hydrolase fold.The crystal structure and catalytic mechanism of hydroxynitrile lyase from passion fruit, Passiflora edulis.Identical active sites in hydroxynitrile lyases show opposite enantioselectivity and reveal possible ancestral mechanism.
P2860
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P2860
Reaction mechanism of hydroxynitrile lyases of the alpha/beta-hydrolase superfamily: the three-dimensional structure of the transient enzyme-substrate complex certifies the crucial role of LYS236.
description
2004 nî lūn-bûn
@nan
2004 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մարտին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Reaction mechanism of hydroxyn ...... es the crucial role of LYS236.
@ast
Reaction mechanism of hydroxyn ...... es the crucial role of LYS236.
@en
Reaction mechanism of hydroxyn ...... es the crucial role of LYS236.
@nl
type
label
Reaction mechanism of hydroxyn ...... es the crucial role of LYS236.
@ast
Reaction mechanism of hydroxyn ...... es the crucial role of LYS236.
@en
Reaction mechanism of hydroxyn ...... es the crucial role of LYS236.
@nl
prefLabel
Reaction mechanism of hydroxyn ...... es the crucial role of LYS236.
@ast
Reaction mechanism of hydroxyn ...... es the crucial role of LYS236.
@en
Reaction mechanism of hydroxyn ...... es the crucial role of LYS236.
@nl
P2093
P2860
P356
P1476
Reaction mechanism of hydroxyn ...... es the crucial role of LYS236.
@en
P2093
Barbara Krammer
Christoph Kratky
Günter Gartler
Helmut Schwab
Karl Gruber
P2860
P304
20501-20510
P356
10.1074/JBC.M401575200
P407
P577
2004-03-03T00:00:00Z