Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies. - Wikidata - awgldk - TriplyDB

Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies.

Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies.

http://www.wikidata.org/entity/Q34309771

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Preferential formation of (5S,6R)-thymine glycol for oligodeoxyribonucleotide synthesis and analysis of drug binding to thymine glycol-containing DNA.DNA base modifications in chromatin of human cancerous tissues Effect of thymine glycol on transcription elongation by T7 RNA polymerase and mammalian RNA polymerase II Advances in chemical carcinogenesis: a historical review and prospective Pharmacogenetics: detecting sensitive populations Efficient formation of the tandem thymine glycol/8-oxo-7,8-dihydroguanine lesion in isolated DNA and the mutagenic and cytotoxic properties of the tandem lesions in Escherichia coli cells.Synthesis and thermodynamic studies of oligonucleotides containing the two isomers of thymine glycol.Nature of mutation in the human hprt gene following in vivo exposure to ionizing radiation of cesium-137.The role of mismatch repair in the prevention of base pair mutations in Saccharomyces cerevisiae.A novel role for Escherichia coli endonuclease VIII in prevention of spontaneous G-->T transversions.Biological properties of single chemical-DNA adducts: a twenty year perspective Synthesis of a 2-selenothymidine phosphoramidite and its incorporation into oligodeoxyribonucleotides.Overexpression of enzymes that repair endogenous damage to DNA.Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides.Artifacts associated with the measurement of oxidized DNA bases.Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein.Oxidative DNA damage: biological significance and methods of analysis.Site-specific radical formation in DNA induced by Cu(II)-H₂O₂ oxidizing system, using ESR, immuno-spin trapping, LC-MS, and MS/MS Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage Mutagenic potentials of damaged nucleic acids produced by reactive oxygen/nitrogen species: approaches using synthetic oligonucleotides and nucleotides: survey and summary The 4-nitroquinoline 1-oxide mutational spectrum in single stranded DNA is characterized by guanine to pyrimidine transversions.Alcohol consumption and oxidative DNA damage.DNA oxidation profiles of copper phenanthrene chemical nucleases.Escherichia coli endonuclease VIII: cloning, sequencing, and overexpression of the nei structural gene and characterization of nei and nei nth mutants Impact of the Circadian Clock on UV-Induced DNA Damage Response and Photocarcinogenesis.Pro-oxidant induced DNA damage in human lymphoblastoid cells: homeostatic mechanisms of genotoxic tolerance Lesion specificity in the base excision repair enzyme hNeil1: modeling and dynamics studies.Synthesis and thermodynamic studies of oligodeoxyribonucleotides containing tandem lesions of thymidine glycol and 8-oxo-2'-deoxyguanosine Endogenous oxidative damage of deoxycytidine in DNA.Stereoselective excision of thymine glycol from oxidatively damaged DNA.The mutagenicity of thymidine glycol in Escherichia coli is increased when it is part of a tandem lesion Chemistry and structural biology of DNA damage and biological consequences Coordination of DNA single strand break repair.Stimulation of N--glycoside transfer in deoxythymidine glycol: mechanism of the initial step in base excision repair.8-Hydroxyguanine levels and repair capacity during mouse embryonic stem cell differentiation.Substitution and deletion mutations induced by 2-hydroxyadenine in Escherichia coli: effects of sequence contexts in leading and lagging strands.Glyoxal, a major product of DNA oxidation, induces mutations at G:C sites on a shuttle vector plasmid replicated in mammalian cells.Characterization of endonuclease III (nth) and endonuclease VIII (nei) mutants of Escherichia coli K-12.Possible role of oxidative damage in metal-induced carcinogenesis.Synthesis of the diastereomers of thymidine glycol, determination of concentrations and rates of interconversion of their cis-trans epimers at equilibrium and demonstration of differential alkali lability within DNA.

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Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies.

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1989 nî lūn-bûn

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1989 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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1989年の論文

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1989年学术文章

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1989年学术文章

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1989年学术文章

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1989年學術文章

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Genetic effects of thymine gly ...... nd molecular modeling studies.

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Genetic effects of thymine gly ...... nd molecular modeling studies.

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Proceedings of the National Academy of Sciences of the United States of America

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Genetic effects of thymine gly ...... nd molecular modeling studies.

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A K Basu

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E L Loechler

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J M Essigmann

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S A Leadon

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P2860

Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases.

Thymine glycol and thymidine glycol in human and rat urine: a possible assay for oxidative DNA damage.

Spontaneous mutagenesis and oxidative damage to DNA in Salmonella typhimurium

Thymine glycols and urea residues in M13 DNA constitute replicative blocks in vitro.

Thymine glycol lesions terminate chain elongation by DNA polymerase I in vitro.

Sequence dependence for bypass of thymine glycols in DNA by DNA polymerase I

Construction and characterization of extrachromosomal probes for mutagenesis by carcinogens: site-specific incorporation of O6-methylguanine into viral and plasmid genomes.

Determination of base sequence in nucleic acids with the electron microscope. V. The thymine-specific reactions of osmium tetroxide with deoxyribonucleic acid and its components.

Base substitutions, frameshifts, and small deletions constitute ionizing radiation-induced point mutations in mammalian cells

In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome

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2682618

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