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The Synaptic Function of α-SynucleinThe bowel and beyond: the enteric nervous system in neurological disordersTargeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's diseaseDNAJC13 mutations in Parkinson diseaseMembrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR.Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes.Synucleins regulate the kinetics of synaptic vesicle endocytosis.α-Synuclein-induced membrane remodeling is driven by binding affinity, partition depth, and interleaflet order asymmetry.Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction.In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cellsAcute increase of α-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation.Upregulation of Parkin in endophilin mutant mice.Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity.A new method for quantitative immunoblotting of endogenous α-synuclein.N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation.Molecular details of α-synuclein membrane association revealed by neutrons and photons.Tubulation by amphiphysin requires concentration-dependent switching from wedging to scaffolding.Biophysics of α-synuclein induced membrane remodellingParkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiationKTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity.Bent out of shape: α-Synuclein misfolding and the convergence of pathogenic pathways in Parkinson's disease.α-Synuclein can inhibit SNARE-mediated vesicle fusion through direct interactions with lipid bilayers.α-Synuclein Mutation Inhibits Endocytosis at Mammalian Central Nerve Terminals.Preparation and Characterization of Stable α-Synuclein Lipoprotein Particlesα-Synuclein oligomers with broken helical conformation form lipoprotein nanoparticles.α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease.Membrane remodeling by α-synuclein and effects on amyloid formation.Exosomes, an Unmasked Culprit in Neurodegenerative Diseases.Advances in the genetics of Parkinson disease.The function of α-synuclein.New insight into neurodegeneration: the role of proteomics.Genetics and genomics of Parkinson's disease.Synaptic failure and α-synuclein.Cell Biology and Pathophysiology of α-Synuclein.Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synucleinThe Role of Lipids Interacting with α-Synuclein in the Pathogenesis of Parkinson's Disease.Synucleins Have Multiple Effects on Presynaptic Architecture.GRP78 clustering at the cell surface of neurons transduces the action of exogenous alpha-synuclein.α-Synuclein senses lipid packing defects and induces lateral expansion of lipids leading to membrane remodeling.Perspective Insights of Exosomes in Neurodegenerative Diseases: A Critical Appraisal.
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Monomeric synucleins generate membrane curvature.
@ast
Monomeric synucleins generate membrane curvature.
@en
Monomeric synucleins generate membrane curvature.
@nl
type
label
Monomeric synucleins generate membrane curvature.
@ast
Monomeric synucleins generate membrane curvature.
@en
Monomeric synucleins generate membrane curvature.
@nl
prefLabel
Monomeric synucleins generate membrane curvature.
@ast
Monomeric synucleins generate membrane curvature.
@en
Monomeric synucleins generate membrane curvature.
@nl
P2860
P356
P1476
Monomeric synucleins generate membrane curvature.
@en
P2093
Christopher H Westphal
Sreeganga S Chandra
P2860
P304
P356
10.1074/JBC.M112.418871
P407
P577
2012-11-26T00:00:00Z