Targeting the molecular chaperone heat shock protein 90 (HSP90): lessons learned and future directions.
about
Hsp90: A New Player in DNA Repair?Targeting the androgen receptor in prostate and breast cancer: several new agents in developmentTargeting Hsp90 in urothelial carcinomaGambogic acid identifies an isoform-specific druggable pocket in the middle domain of Hsp90βPhase I study of BIIB028, a selective heat shock protein 90 inhibitor, in patients with refractory metastatic or locally advanced solid tumors.Survivin, a molecular target for therapeutic interventions in squamous cell carcinoma.Microtubules and their role in cellular stress in cancerAn Impermeant Ganetespib Analog Inhibits Extracellular Hsp90-Mediated Cancer Cell Migration that Involves Lysyl Oxidase 2-like ProteinCorrelation between PDZK1, Cdc37, Akt and breast cancer malignancy: the role of PDZK1 in cell growth through Akt stabilization by increasing and interacting with Cdc37Gene silencing mediated by endogenous microRNAs under heat stress conditions in mammalian cellsLysine methyltransferase Smyd2 suppresses p53-dependent cardiomyocyte apoptosis.Misfolded proteins: from little villains to little helpers in the fight against cancer.Comparative Study of 17-AAG and NVP-AUY922 in Pancreatic and Colorectal Cancer Cells: Are There Common Determinants of Sensitivity?A physiologically based pharmacokinetic model of alvespimycin in mice and extrapolation to rats and humans.Association between HSP90 and Her2 in gastric and gastroesophageal carcinomas.Heat shock protein 90 inhibitor NVP-AUY922 exerts potent activity against adult T-cell leukemia-lymphoma cells.High-throughput screen of natural product libraries for hsp90 inhibitors.The heat shock protein 90 inhibitor BIIB021 suppresses the growth of T and natural killer cell lymphomas.Geldanamycin Enhances Retrograde Transport of Shiga Toxin in HEp-2 Cells.The HSP90 inhibitor ganetespib: A potential effective agent for Acute Myeloid Leukemia in combination with cytarabineSelection and Characterization of Single Chain Antibody Fragments Specific for Hsp90 as a Potential Cancer Targeting Molecule.Sensitization of chemo-resistant human chronic myeloid leukemia stem-like cells to Hsp90 inhibitor by SIRT1 inhibition.First Structural View of a Peptide Interacting with the Nucleotide Binding Domain of Heat Shock Protein 90The novel HSP90 inhibitor AT13387 potentiates radiation effects in squamous cell carcinoma and adenocarcinoma cells.Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1.Molecular imaging of EGFR and CD44v6 for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma modelPhase II trial of gemcitabine and tanespimycin (17AAG) in metastatic pancreatic cancer: a Mayo Clinic Phase II Consortium study.Efficiency of AUY922 in mice with adult T-cell leukemia/lymphomaHsp90 inhibitor 17-DMAG decreases expression of conserved herpesvirus protein kinases and reduces virus production in Epstein-Barr virus-infected cellsSynthesis and Biological Evaluation of Novobiocin Core Analogues as Hsp90 Inhibitors.Y-632 inhibits heat shock protein 90 (Hsp90) function by disrupting the interaction between Hsp90 and Hsp70/Hsp90 organizing protein, and exerts antitumor activity in vitro and in vivoHeat Shock Protein (HSP) Drug Discovery and Development: Targeting Heat Shock Proteins in Disease.A "Double-Edged" Scaffold: Antitumor Power within the Antibacterial Quinolone.Antileukemic Scalarane Sesterterpenoids and Meroditerpenoid from Carteriospongia (Phyllospongia) sp., Induce Apoptosis via Dual Inhibitory Effects on Topoisomerase II and Hsp90.Synergistic enhancement of cancer therapy using a combination of heat shock protein targeted HPMA copolymer-drug conjugates and gold nanorod induced hyperthermia.Targeting the LKB1 tumor suppressor.Clinical applications of mouse models for breast cancer engaging HER2/neu.Drug Resistance Mechanisms in Non-Small Cell Lung Carcinoma.B-cell antigen receptor signaling in chronic lymphocytic leukemia: therapeutic targets and translational opportunities.Predictive biomarkers for cancer therapy with PARP inhibitors.
P2860
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P2860
Targeting the molecular chaperone heat shock protein 90 (HSP90): lessons learned and future directions.
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Targeting the molecular chaper ...... learned and future directions.
@ast
Targeting the molecular chaper ...... learned and future directions.
@en
Targeting the molecular chaperone heat shock protein 90
@nl
type
label
Targeting the molecular chaper ...... learned and future directions.
@ast
Targeting the molecular chaper ...... learned and future directions.
@en
Targeting the molecular chaperone heat shock protein 90
@nl
prefLabel
Targeting the molecular chaper ...... learned and future directions.
@ast
Targeting the molecular chaper ...... learned and future directions.
@en
Targeting the molecular chaperone heat shock protein 90
@nl
P2093
P1476
Targeting the molecular chaper ...... learned and future directions.
@en
P2093
Bahareh Tavana
David S Hong
Goldy C George
Joann Aaron
Udai Banerji
P304
P356
10.1016/J.CTRV.2012.10.001
P577
2012-11-28T00:00:00Z