Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines.
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The GABA B receptor agonist CGP44532 and the positive modulator GS39783 reverse some behavioural changes related to positive syndromes of psychosis in mice.Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in ratsSyntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptorsCharacterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptorsGABAB receptor ligands for the treatment of alcohol use disorder: preclinical and clinical evidenceThe GABA(B) receptor positive modulator BHF177 attenuated anxiety, but not conditioned fear, in rats.Mouse hippocampal GABAB1 but not GABAB2 subunit-containing receptor complex levels are paralleling retrieval in the multiple-T-maze.The GABAβ receptor as a target for antidepressant drug actionThe oligomeric state sets GABA(B) receptor signalling efficacyPositive allosteric modulation of GABAB receptors ameliorates sensorimotor gating in rodent models.The age of anxiety: role of animal models of anxiolytic action in drug discovery.The rostral anterior cingulate cortex modulates the efficiency of amygdala-dependent fear learning.Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in miceIntra-nucleus accumbens shell injections of R(+)- and S(-)-baclofen bidirectionally alter binge-like ethanol, but not saccharin, intake in C57Bl/6J mice.GABAB receptor-positive modulators: enhancement of GABAB receptor agonist effects in vivo.Administration of GABA(B) receptor positive allosteric modulators inhibit the expression of previously established methamphetamine-induced conditioned place preference.The GABAB receptor-positive modulator GS39783 and the GABAB receptor agonist baclofen attenuate the reward-facilitating effects of cocaine: intracranial self-stimulation studies in the rat.Assessment of GABA-B, metabotropic glutamate, and opioid receptor involvement in an animal model of binge drinkingHyperdopaminergia and altered locomotor activity in GABAB1-deficient mice.GABA(B) receptor-positive modulation decreases selective molecular and behavioral effects of cocaineCGP7930: a positive allosteric modulator of the GABAB receptor.Evaluation of peripheral versus central effects of GABA(B) receptor activation using a novel, positive allosteric modulator of the GABA(B) receptor ADX71943, a pharmacological tool compound with a fully peripheral activity profile.Bidirectional enantioselective effects of the GABAB receptor agonist baclofen in two mouse models of excessive ethanol consumption.Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome.Activation of the GABA(B) Receptor Prevents Nicotine-Induced Locomotor Stimulation in Mice.Effects of the GABAB receptor-positive modulators CGP7930 and rac-BHFF in baclofen- and γ-hydroxybutyrate-discriminating pigeons.Positive allosteric modulation of the GABA(B) receptor by GS39783 attenuates the locomotor stimulant actions of ethanol and potentiates the induction of locomotor sensitization.Comparison of the effect of the GABAΒ receptor agonist, baclofen, and the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in 3 different lines of alcohol-preferring rats.Anxiety-like behaviors at the end of the nocturnal period in sP rats with a "history" of unpredictable, limited access to alcoholLigand-guided homology modelling of the GABAB2 subunit of the GABAB receptor.Biphasic effects of cannabinoids in anxiety responses: CB1 and GABA(B) receptors in the balance of GABAergic and glutamatergic neurotransmission.Targeting opioid receptor heterodimers: strategies for screening and drug developmentDiscriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse.GABAB receptor-mediated, layer-specific synaptic plasticity reorganizes gamma-frequency neocortical response to stimulation.Mechanism-based medication development for the treatment of nicotine dependence.Review. Neurobiology of nicotine dependence.Involvement of GABAB Receptor Signaling in Antipsychotic-like Action of the Novel Orthosteric Agonist of the mGlu4 Receptor, LSP4-2022.Involvement of glutamatergic and GABAergic systems in nicotine dependence: Implications for novel pharmacotherapies for smoking cessation.Allosteric modulators of GABA(B) receptors: mechanism of action and therapeutic perspective.ADX71441, a novel, potent and selective positive allosteric modulator of the GABA(B) receptor, shows efficacy in rodent models of overactive bladder.
P2860
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P2860
Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines.
description
2004 nî lūn-bûn
@nan
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Behavioral characterization of ...... h baclofen or benzodiazepines.
@ast
Behavioral characterization of ...... h baclofen or benzodiazepines.
@en
Behavioral characterization of ...... h baclofen or benzodiazepines.
@nl
type
label
Behavioral characterization of ...... h baclofen or benzodiazepines.
@ast
Behavioral characterization of ...... h baclofen or benzodiazepines.
@en
Behavioral characterization of ...... h baclofen or benzodiazepines.
@nl
prefLabel
Behavioral characterization of ...... h baclofen or benzodiazepines.
@ast
Behavioral characterization of ...... h baclofen or benzodiazepines.
@en
Behavioral characterization of ...... h baclofen or benzodiazepines.
@nl
P2093
P356
P1476
Behavioral characterization of ...... h baclofen or benzodiazepines.
@en
P2093
Bernhard Bettler
Cedric Mombereau
Conrad Gentsch
Frederique Chaperon
Klemens Kaupmann
Kurt Lingenhoehl
Peter H Kelly
Will P J M Spooren
Wolfgang Froestl
P304
P356
10.1124/JPET.104.066753
P407
P577
2004-04-27T00:00:00Z