Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation - Wikidata - awgldk - TriplyDB

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

http://www.wikidata.org/entity/Q34317380

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Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy Targeting EZH2 in cancer EZH2 in normal hematopoiesis and hematological malignancies Progress in epigenetic histone modification analysis by mass spectrometry for clinical investigations Mutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomas The complexity of epigenetic diseases Synthesis of lysine methyltransferase inhibitors Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications Chemical probes of histone lysine methyltransferases Design of small molecule epigenetic modulators The epigenetic basis of diffuse large B-cell lymphoma Recent progress toward epigenetic therapies: the example of mixed lineage leukemia Cancer epigenetics drug discovery and development: the challenge of hitting the mark Gain-of-function mutation of chromatin regulators as a tumorigenic mechanism and an opportunity for therapeutic intervention Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5 Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain Histone lysine methyltransferases as anti-cancer targets for drug discovery The crosstalk between microRNAs and the Wnt/β-catenin signaling pathway in cancer EZH2 in Bladder Cancer, a Promising Therapeutic Target Diverse involvement of EZH2 in cancer epigenetics Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8 Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2 Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML)Weaver Syndrome-Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro MiR-101 Targets the EZH2/Wnt/β-Catenin the Pathway to Promote the Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells.Disruption of the MYC-miRNA-EZH2 loop to suppress aggressive B-cell lymphoma survival and clonogenicity.Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS EZH2: not EZHY (easy) to deal.Diffuse large B-cell lymphoma: can genomics improve treatment options for a curable cancer?A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination.Therapeutic targeting using tumor specific peptides inhibits long non-coding RNA HOTAIR activity in ovarian and breast cancer.EZH2 alterations in follicular lymphoma: biological and clinical correlations.Hsp90 inhibition destabilizes Ezh2 protein in alloreactive T cells and reduces graft-versus-host disease in mice Histones and their modifications in ovarian cancer - drivers of disease and therapeutic targets.Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, S Ezh2 regulates transcriptional and posttranslational expression of T-bet and promotes Th1 cell responses mediating aplastic anemia in mice.

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Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

http://www.wikidata.org/entity/Q34317380

description

2012 nî lūn-bûn

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2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

@zh-hk

2012年論文

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2012年論文

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2012年论文

@wuu

name

Selective inhibition of Ezh2 b ...... ocks tumor cells proliferation

@ast

Selective inhibition of Ezh2 b ...... ocks tumor cells proliferation

@en

Selective inhibition of Ezh2 b ...... ocks tumor cells proliferation

@nl

type

label

Selective inhibition of Ezh2 b ...... ocks tumor cells proliferation

@ast

Selective inhibition of Ezh2 b ...... ocks tumor cells proliferation

@en

Selective inhibition of Ezh2 b ...... ocks tumor cells proliferation

@nl

prefLabel

Selective inhibition of Ezh2 b ...... ocks tumor cells proliferation

@ast

Selective inhibition of Ezh2 b ...... ocks tumor cells proliferation

@en

Selective inhibition of Ezh2 b ...... ocks tumor cells proliferation

@nl

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PNAS.1210371110

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Selective inhibition of Ezh2 b ...... ocks tumor cells proliferation

@en

P2093

Chris X Lu

http://www.w3.org/2001/XMLSchema#string

En Li

http://www.w3.org/2001/XMLSchema#string

Grace Feng

http://www.w3.org/2001/XMLSchema#string

Guobin Li

http://www.w3.org/2001/XMLSchema#string

HoMan Chan

http://www.w3.org/2001/XMLSchema#string

Hong Fan

http://www.w3.org/2001/XMLSchema#string

Ji-Hu Zhang

http://www.w3.org/2001/XMLSchema#string

Jialuo Fang

http://www.w3.org/2001/XMLSchema#string

Jue Zeng

http://www.w3.org/2001/XMLSchema#string

Justin Gu

http://www.w3.org/2001/XMLSchema#string

P2860

Cell cycle, CDKs and cancer: a changing paradigm

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma.

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

Control of developmental regulators by Polycomb in human embryonic stem cells

SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex

P304

21360-21365

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scholarly article

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10.1073/PNAS.1210371110

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52

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109

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2012-12-10T00:00:00Z

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233909489

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23236167

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3535655

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