IL-7 signaling must be intermittent, not continuous, during CD8⁺ T cell homeostasis to promote cell survival instead of cell death.
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Naïve T Cell Homeostasis Regulated by Stress Responses and TCR SignalingModulation of T Cell Metabolism and Function through Calcium SignalingMechanism of Action of IL-7 and Its Potential Applications and Limitations in Cancer ImmunotherapyRe-adapting T cells for cancer therapy: from mouse models to clinical trials.Basal NF-κB controls IL-7 responsiveness of quiescent naïve T cellsITK tunes IL-4-induced development of innate memory CD8+ T cells in a γδ T and invariant NKT cell-independent manner.T-Cell Therapy Using Interleukin-21-Primed Cytotoxic T-Cell Lymphocytes Combined With Cytotoxic T-Cell Lymphocyte Antigen-4 Blockade Results in Long-Term Cell Persistence and Durable Tumor RegressionExpansion of highly differentiated cytotoxic terminally differentiated effector memory CD8+ T cells in a subset of clinically stable kidney transplant recipients: a potential marker for late graft dysfunctionThe signaling symphony: T cell receptor tunes cytokine-mediated T cell differentiationInfection history determines the differentiation state of human CD8+ T cellsGeneralized Liver- and Blood-Derived CD8+ T-Cell Impairment in Response to Cytokines in Chronic Hepatitis C Virus InfectionEffect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus MacaquesIL-7R signaling in regulatory T cells maintains peripheral and allograft tolerance in mice.Efforts of the human immune system to maintain the peripheral CD8+ T cell compartment after childhood thymectomyOut-of-Sequence Signal 3 Paralyzes Primary CD4(+) T-Cell-Dependent Immunity.Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity.IL-15 signaling promotes adoptive effector T-cell survival and memory formation in irradiation-induced lymphopeniaThe aged lymphoid tissue environment fails to support naïve T cell homeostasisSurvival of mature T cells depends on signaling through HOIP.NF-κB signaling mediates homeostatic maturation of new T cells.Gimap and T cells: a matter of life or death.Blood and beyond: properties of circulating and tissue-resident human virus-specific αβ CD8(+) T cells.The expanding role of IL-7 and thymic stromal lymphopoietin as therapeutic target for rheumatoid arthritis.Homeostatic expansion as a barrier to lymphocyte depletion strategies.The common γ-chain cytokine receptor: tricks-and-treats for T cells.Interleukin-7 Modulates Anti-Tumor CD8+ T Cell Responses via Its Action on Host Cells.New insights into IL-7 signaling pathways during early and late T cell development.Distinct IL-7 signaling in recent thymic emigrants versus mature naïve T cells controls T-cell homeostasis.Expression of biologically active bovine interleukin 7 and evaluating the activity in vitro.Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals.Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells.Immunoregulation by IL-7R-targeting antibody-drug conjugates: overcoming steroid-resistance in cancer and autoimmune disease.T cell up-regulation of CD127 is associated with reductions in the homeostatic set point of the peripheral T cell pool during malnourishment.Regression of metastatic Merkel cell carcinoma following transfer of polyomavirus-specific T cells and therapies capable of re-inducing HLA class-ITracking the Fate and Origin of Clinically Relevant Adoptively Transferred CD8+ T Cells In Vivo.Adjuvant IL-7 potentiates adoptive T cell therapy by amplifying and sustaining polyfunctional antitumor CD4+ T cellsCloning and Expression of Recombinant Human Interleukin-7 in Chinese Hamster Ovary (CHO) Cells.IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion.Forced expression of IL-7R promotes CD8 T cell cytotoxicity to self antigen.Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System.
P2860
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P2860
IL-7 signaling must be intermittent, not continuous, during CD8⁺ T cell homeostasis to promote cell survival instead of cell death.
description
2012 nî lūn-bûn
@nan
2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
IL-7 signaling must be intermi ...... urvival instead of cell death.
@ast
IL-7 signaling must be intermi ...... urvival instead of cell death.
@en
IL-7 signaling must be intermi ...... urvival instead of cell death.
@nl
type
label
IL-7 signaling must be intermi ...... urvival instead of cell death.
@ast
IL-7 signaling must be intermi ...... urvival instead of cell death.
@en
IL-7 signaling must be intermi ...... urvival instead of cell death.
@nl
prefLabel
IL-7 signaling must be intermi ...... urvival instead of cell death.
@ast
IL-7 signaling must be intermi ...... urvival instead of cell death.
@en
IL-7 signaling must be intermi ...... urvival instead of cell death.
@nl
P2093
P2860
P356
P1433
P1476
IL-7 signaling must be intermi ...... urvival instead of cell death.
@en
P2093
Alfred Singer
Anthony Adams
Julien Thomas
Jung-Hyun Park
Leonid A Pobezinsky
Motoko Y Kimura
Terry I Guinter
Xuguang Tai
P2860
P304
P356
10.1038/NI.2494
P407
P577
2012-12-16T00:00:00Z