Backbone modification of nucleic acids: synthesis, structure and therapeutic applications.
about
Improvements in siRNA properties mediated by 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (FANA)Current advances in Phi29 pRNA biology and its application in drug deliveryIdentification of thioaptamer ligand against E-selectin: potential application for inflamed vasculature targetingComputation of DNA backbone conformations.Oxetane locked thymidine in the Dickerson-Drew dodecamer causes local base pairing distortions -- an NMR structure and hydration study.Design and synthesis of dephosphono DNA analogues containing 1,2,3-triazole linker and their UV-melting studies with DNA/RNA.FTIR and UV spectroscopy studies of triplex formation between alpha-oligonucleotides with non-ionic phoshoramidate linkages and DNA targets.Bioimaging of nucleolin aptamer-containing 5-(N-benzylcarboxyamide)-2'-deoxyuridine more capable of specific binding to targets in cancer cellsThermodynamics of RNA duplexes modified with unlocked nucleic acid nucleotides.Combinatorial selection of DNA thioaptamers targeted to the HA binding domain of human CD44Functional tuning of nucleic acids by chemical modifications: tailored oligonucleotides as drugs, devices, and diagnostics.Differential analogue binding by two classes of c-di-GMP riboswitchesModulating Anti-MicroRNA-21 Activity and Specificity Using Oligonucleotide Derivatives and Length Optimization.Ribonuclease-Activated Cancer Prodrug.Modified AS1411 Aptamer Suppresses Hepatocellular Carcinoma by Up-Regulating Galectin-14.Artificial DNA and surface plasmon resonance.Modulation of gene expression by antisense and antigene oligodeoxynucleotides and small interfering RNA.A versatile method for the preparation of conjugates of peptides with DNA/PNA/analog by employing chemo-selective click reaction in water.Nuclease-Resistant c-di-AMP Derivatives That Differentially Recognize RNA and Protein ReceptorsCu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition reaction in nucleoside, nucleotide, and oligonucleotide chemistry.Chemical modification of oligonucleotides for therapeutic, bioanalytical and other applications.Non-natural nucleic acids for synthetic biology.Antisense drug discovery and development.The DNA and RNA sugar-phosphate backbone emerges as the key player. An overview of quantum-chemical, structural biology and simulation studies.Synthesis and Excellent Duplex Stability of Oligonucleotides Containing 2'-Amino-LNA Functionalized with Galactose Units.4'-Epi-DNA: A DNA Mimic Containing 4'-hydroxymethyl-α-l-Xylo-Thymidine with Compact Backbone like RNA.Uptake, cellular distribution and novel cellular binding proteins of immunostimulatory CpG oligodeoxynucleotides in glioblastoma cells.Biophysical and cellular-uptake properties of mixed-sequence pyrrolidine-amide oligonucleotide mimics.Chimeric (aeg-pyrrolidine)PNAs: synthesis and stereo-discriminative duplex binding with DNA/RNA.Amino/guanidino-functionalized N-(pyrrolidin-2-ethyl)glycine-based pet-PNA: design, synthesis and binding with DNA/RNA.Oligonucleotide therapeutics: chemistry, delivery and clinical progress.Immunotherapy of CD30-expressing lymphoma using a highly stable ssDNA aptamer.Use of nucleic Acid analogs for the study of nucleic Acid interactionsNMR studies of the conformational effect of single and double 3'-S-phosphorothiolate substitutions within deoxythymidine trinucleotides.Microwave-assisted synthesis of dinucleoside analogues containing a thiazolidin-4-one linkage via one-pot tandem Staudinger/aza-Wittig/cyclization.FTIR and UV spectroscopy studies of triplex formation between pyrimidine methoxyethylphosphoramidates alpha-oligodeoxynucleotides and ds DNA targets.Design and synthesis of LNA-based mercaptoacetamido-linked nucleoside dimers.Locked nucleic acids and intercalating nucleic acids in the design of easily denaturing nucleic acids: thermal stability studies.Nucleic acids: function and potential for abiogenesis.Diagnostic Applications of Morpholinos and Label-Free Electrochemical Detection of Nucleic Acids.
P2860
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P2860
Backbone modification of nucleic acids: synthesis, structure and therapeutic applications.
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
Backbone modification of nucle ...... and therapeutic applications.
@ast
Backbone modification of nucle ...... and therapeutic applications.
@en
Backbone modification of nucle ...... and therapeutic applications.
@nl
type
label
Backbone modification of nucle ...... and therapeutic applications.
@ast
Backbone modification of nucle ...... and therapeutic applications.
@en
Backbone modification of nucle ...... and therapeutic applications.
@nl
prefLabel
Backbone modification of nucle ...... and therapeutic applications.
@ast
Backbone modification of nucle ...... and therapeutic applications.
@en
Backbone modification of nucle ...... and therapeutic applications.
@nl
P356
P1476
Backbone modification of nucleic acids: synthesis, structure and therapeutic applications
@en
P2093
J Micklefield
P304
P356
10.2174/0929867013372391
P577
2001-08-01T00:00:00Z