PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding - Wikidata - awgldk - TriplyDB

PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

http://www.wikidata.org/entity/Q34322599

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Ubiquitin is phosphorylated by PINK1 to activate parkin Ataxin-3 is a multivalent ligand for the parkin Ubl domain Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection Evaluation of Models of Parkinson's Disease The different facets of organelle interplay-an overview of organelle interactions Quantifying ubiquitin signaling RBR E3 ubiquitin ligases: new structures, new insights, new questions RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications Parkin structure and function Mechanisms of drug-induced liver injury Role of p62/SQSTM1 in liver physiology and pathogenesis After the banquet: mitochondrial biogenesis, mitophagy, and cell survival Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin Activation of the E3 ubiquitin ligase Parkin.Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism Structure of the human Parkin ligase domain in an autoinhibited state Structure of parkin reveals mechanisms for ubiquitin ligase activation Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation Structural insights into Parkin substrate lysine targeting from minimal Miro substrates Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity Site-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation.Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation.Quantitative proteomic analysis of Parkin substrates in Drosophila neurons.Structural and functional insights to ubiquitin-like protein conjugation.Keeping the immune system in check: a role for mitophagy.A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently PINK1 triggers autocatalytic activation of Parkin to specify cell fate decisions Conformational rearrangements in the pro-apoptotic protein, Bax, as it inserts into mitochondria: a cellular death switch.Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin Ubiquitination increases parkin activity to promote autophagic α-synuclein clearance.A polyubiquitin chain reaction: parkin recruitment to damaged mitochondria Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy.Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin Interaction between RING1 (R1) and the Ubiquitin-like (UBL) Domains Is Critical for the Regulation of Parkin Activity.

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P2860

PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

http://www.wikidata.org/entity/Q34322599

description

2013 nî lūn-bûn

@nan

2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հունվարին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

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2013年論文

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2013年论文

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name

PINK1 drives Parkin self-assoc ...... tream of mitochondrial binding

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PINK1 drives Parkin self-assoc ...... tream of mitochondrial binding

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PINK1 drives Parkin self-assoc ...... tream of mitochondrial binding

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type

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PINK1 drives Parkin self-assoc ...... tream of mitochondrial binding

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PINK1 drives Parkin self-assoc ...... tream of mitochondrial binding

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PINK1 drives Parkin self-assoc ...... tream of mitochondrial binding

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prefLabel

PINK1 drives Parkin self-assoc ...... tream of mitochondrial binding

@ast

PINK1 drives Parkin self-assoc ...... tream of mitochondrial binding

@en

PINK1 drives Parkin self-assoc ...... tream of mitochondrial binding

@nl

P1433

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P1433

Journal of Cell Biology

P1476

PINK1 drives Parkin self-assoc ...... tream of mitochondrial binding

@en

P2093

Derek P Narendra

http://www.w3.org/2001/XMLSchema#string

Ephrem Tekle

http://www.w3.org/2001/XMLSchema#string

Richard J Youle

http://www.w3.org/2001/XMLSchema#string

Seok Min Jin

http://www.w3.org/2001/XMLSchema#string

Soojay Banerjee

http://www.w3.org/2001/XMLSchema#string

P2860

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update

LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

Autoregulation of Parkin activity through its ubiquitin-like domain

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

P304

163-172

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scholarly article

P356

10.1083/JCB.201210111

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P407

P433

2

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P478

200

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P50

Michael Lazarou

P577

2013-01-14T00:00:00Z

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P5875

234134520

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P698

23319602

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P932

3549971

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