Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity. - Wikidata - awgldk - TriplyDB

Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity.

Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity.

http://www.wikidata.org/entity/Q34333517

about

Regulation of exercise-stimulated glucose uptake in skeletal muscle AMPK activators: mechanisms of action and physiological activities Past strategies and future directions for identifying AMP-activated protein kinase (AMPK) modulators AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes Supplementation with α-lipoic acid, CoQ10, and vitamin E augments running performance and mitochondrial function in female mice mTOR signaling in tumorigenesis Dissecting the role of AMP-activated protein kinase in human diseases.Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK Targeted therapies of the LKB1/AMPK pathway for the treatment of insulin resistance Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer.Tissue taurine depletion alters metabolic response to exercise and reduces running capacity in mice.The Murphy Roths Large (MRL) mouse strain is naturally resistant to high fat diet-induced hyperglycemia Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo Enhanced lipid oxidation and maintenance of muscle insulin sensitivity despite glucose intolerance in a diet-induced obesity mouse model AMP-activated protein kinase suppresses matrix metalloproteinase-9 expression in mouse embryonic fibroblasts.Bacterial peptidoglycan stimulates adipocyte lipolysis via NOD1.NOD1 activators link innate immunity to insulin resistance AMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise.Voluntary physical activity prevents insulin resistance in a tissue specific manner Fighting obesity: When muscle meets fat.High-intensity exercise training increases the diversity and metabolic capacity of the mouse distal gut microbiota during diet-induced obesity.The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice.AMP-Activated Protein Kinase (AMPK) and Energy-Sensing in the Brain The AMPK β2 subunit is required for energy homeostasis during metabolic stress Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation.Dystrophin-glycoprotein complex regulates muscle nitric oxide production through mechanoregulation of AMPK signaling Impaired glucose metabolism and exercise capacity with muscle-specific glycogen synthase 1 (gys1) deletion in adult mice.AMPK and Exercise: Glucose Uptake and Insulin Sensitivity.Effects of chemically induced ovarian failure on voluntary wheel-running exercise and cardiac adaptation in mice.Two weeks of metformin treatment induces AMPK-dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle.The IL-6 Paradox: Context Dependent Interplay of SOCS3 and AMPK.Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 &2 and AMP-activated Protein Kinase in the Kidney Exercise reverses age-related vulnerability of the retina to injury by preventing complement-mediated synapse elimination via a BDNF-dependent pathway.A metabolic link to skeletal muscle wasting and regeneration.Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function.Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle.Muscle-specific AMPK β1β2-null mice display a myopathy due to loss of capillary density in nonpostural muscles.PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis.AMPKβ subunits: more than just a scaffold in the formation of AMPK complex.

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P2860

Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity.

http://www.wikidata.org/entity/Q34333517

description

2010 nî lūn-bûn

@nan

2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Whole body deletion of AMP-act ...... ctivity and exercise capacity.

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Whole body deletion of AMP-act ...... ctivity and exercise capacity.

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Whole body deletion of AMP-act ...... ctivity and exercise capacity.

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Whole body deletion of AMP-act ...... ctivity and exercise capacity.

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Whole body deletion of AMP-act ...... ctivity and exercise capacity.

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Whole body deletion of AMP-act ...... ctivity and exercise capacity.

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Whole body deletion of AMP-act ...... ctivity and exercise capacity.

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Whole body deletion of AMP-act ...... ctivity and exercise capacity.

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JBC.M110.102434

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Journal of Biological Chemistry

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Whole body deletion of AMP-act ...... activity and exercise capacity

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Bryce J W van Denderen

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Duncan J Campbell

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Frank Koentgen

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Gregory R Steinberg

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Jane Honeyman

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Jonathan D Schertzer

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Kimberly Hewitt

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Matthew J Watt

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René Koopman

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Sebastian B Jørgensen

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P2860

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle

The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity

Isoform-specific and exercise intensity-dependent activation of 5'-AMP-activated protein kinase in human skeletal muscle

Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase

AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation

Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance

A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle

AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270)

Expression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscle

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37198-37209

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10.1074/JBC.M110.102434

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48

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285

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Bruce Ernest Kemp

Gordon S. Lynch

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2010-09-20T00:00:00Z

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20855892

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2988326

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