Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter. - Wikidata - awgldk - TriplyDB

Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter.

Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter.

http://www.wikidata.org/entity/Q34342494

about

Genetic manipulation for inherited neurodegenerative diseases: myth or reality?Retinal dystrophies, genomic applications in diagnosis and prospects for therapy A Survey of Retinal Remodeling Restoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic Tool Optogenetic Vision Restoration Using Rhodopsin for Enhanced Sensitivity.Biophysical Properties of Optogenetic Tools and Their Application for Vision Restoration Approaches Therapeutic potential of optogenetic neuromodulation Optogenetics.Efficient gene delivery to photoreceptors using AAV2/rh10 and rescue of the Rho(-/-) mouse Variable phenotypic expressivity in inbred retinal degeneration mouse lines: A comparative study of C3H/HeOu and FVB/N rd1 mice Novel Methodology for Creating Macaque Retinas with Sortable Photoreceptors and Ganglion Cells.Let There Be Light: Gene and Cell Therapy for Blindness.AAV-mediated transduction and targeting of retinal bipolar cells with improved mGluR6 promoters in rodents and primates.Strategies for targeting primate neural circuits with viral vectors.Advances in Gene Therapy for Diseases of the Eye.Red-shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina.Single residue AAV capsid mutation improves transduction of photoreceptors in the Abca4-/- mouse and bipolar cells in the rd1 mouse and human retina ex vivo.Gene therapy approaches for the treatment of retinal disorders Present Molecular Limitations of ON-Bipolar Cell Targeted Gene Therapy.Optopharmacological tools for restoring visual function in degenerative retinal diseases.Taking Stock of Retinal Gene Therapy: Looking Back and Moving Forward.Challenges for the application of optical stimulation in the cochlea for the study and treatment of hearing loss.Evaluation of Dose and Safety of AAV7m8 and AAV8BP2 in the Non-Human Primate Retina.Insight into the mechanisms of enhanced retinal transduction by the engineered AAV2 capsid variant -7m8.Retinal Gene Therapy: Surgical Vector Delivery in the Translation to Clinical Trials.Long-term expression of melanopsin and channelrhodopsin causes no gross alterations in the dystrophic dog retina.Tropism of engineered and evolved recombinant AAV serotypes in the rd1 mouse and ex vivo primate retina.CREATEd viruses go global.Spinal nociceptive circuit analysis with recombinant adeno-associated viruses: the impact of serotypes and promoters.Restoration of Vision with Ectopic Expression of Human Rod Opsin.Intravitreal delivery of a novel AAV vector targets ON bipolar cells and restores visual function in a mouse model of complete congenital stationary night blindness.Long-term restoration of visual function in end-stage retinal degeneration using subretinal human melanopsin gene therapy.Alterations in Kainate Receptor and TRPM1 Localization in Bipolar Cells after Retinal Photoreceptor Degeneration.A Novel Retinal Ganglion Cell Promoter for Utility in AAV Vectors An alternate route for adeno-associated virus entry independent of AAVR.Synthetic adeno-associated viral vector efficiently targets mouse and non-human primate retina in vivo.Interactive Light Stimulus Generation with High Performance Real-Time Image Processing and Simple Scripting.Efficacy and Safety of Glycosidic Enzymes for Improved Gene Delivery to the Retina following Intravitreal Injection in Mice.Transduction Patterns of Adeno-associated Viral Vectors in a Laser-Induced Choroidal Neovascularization Mouse Model.SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis.

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Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter.

http://www.wikidata.org/entity/Q34342494

description

2014 nî lūn-bûn

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2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի օգոստոսին հրատարակված գիտական հոդված

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2014年の論文

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年學術文章

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name

Efficient transduction and opt ...... ted virus capsid and promoter.

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Efficient transduction and opt ...... ted virus capsid and promoter.

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Efficient transduction and opt ...... ted virus capsid and promoter.

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Efficient transduction and opt ...... ted virus capsid and promoter.

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EMBO Molecular Medicine

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Efficient transduction and opt ...... ated virus capsid and promoter

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Agota-Enikő Kacsó

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Andreas Reimann

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Botond Roska

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Hubertus Kohler

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Jean Bennett

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Josephine Juttner

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Luk H Vandenberghe

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Pamela S Lagali

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Therese Cronin

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P2860

The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy.

Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration

Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial

Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration

Channelrhodopsin-2, a directly light-gated cation-selective membrane channel

Safety and efficacy of gene transfer for Leber's congenital amaurosis

Human RPE65 gene therapy for Leber congenital amaurosis: persistence of early visual improvements and safety at 1 year

Four-base codon mediated mRNA display to construct peptide libraries that contain multiple nonnatural amino acids.

Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey

Structure of Adeno-Associated Virus Serotype 8, a Gene Therapy Vector

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1175-1190

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10.15252/EMMM.201404077

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9

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Volker Busskamp

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2014-09-01T00:00:00Z

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264461231

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