Limiting the power of p53 through the ubiquitin proteasome pathway. - Wikidata - awgldk - TriplyDB

Limiting the power of p53 through the ubiquitin proteasome pathway.

Limiting the power of p53 through the ubiquitin proteasome pathway.

http://www.wikidata.org/entity/Q34342940

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Clinical Overview of MDM2/X-Targeted Therapies Targeting Oncogenic Mutant p53 for Cancer Therapy Cell Cycle-Dependent Localization of Dynactin Subunit p150 glued at Centrosome Establishment of a Wheat Cell-Free Synthesized Protein Array Containing 250 Human and Mouse E3 Ubiquitin Ligases to Identify Novel Interaction between E3 Ligases and Substrate Proteins The tumour suppressor CYLD regulates the p53 DNA damage response The ubiquitin ligase LIN41/TRIM71 targets p53 to antagonize cell death and differentiation pathways during stem cell differentiation.MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer.BRCA1 and p53 tumor suppressor molecules in Alzheimer's disease.Inhibitors of the AAA+ chaperone p97 Anti-tumoral effect of desmethylclomipramine in lung cancer stem cells.SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence.The dynamic behavior of Ect2 in response to DNA damage.Characterization of cancer-associated missense mutations in MDM2.The benefits of local depletion: The centrosome as a scaffold for ubiquitin-proteasome-mediated degradation Regulation of tumor suppressor EAF2 polyubiquitination by ELL1 and SIAH2 in prostate cancer cells Aberrant splicing of the DMP1-ARF-MDM2-p53 pathway in cancer Dynamics of p53: A Master Decider of Cell Fate.Regulation of the Tumor-Suppressor Function of the Class III Phosphatidylinositol 3-Kinase Complex by Ubiquitin and SUMO TP53: an oncogene in disguise.TP53 Mutations in Head and Neck Squamous Cell Carcinoma and Their Impact on Disease Progression and Treatment Response.Establishment of a novel human medulloblastoma cell line characterized by highly aggressive stem-like cells.Human EHMT2/G9a activates p53 through methylation-independent mechanism.Systemic genome screening identifies the outcome associated focal loss of long noncoding RNA PRAL in hepatocellular carcinoma.PAK4 regulates G6PD activity by p53 degradation involving colon cancer cell growth.Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA.Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf-/- mouse model.The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain.Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish Improvement of gemcitabine sensitivity of p53-mutated pancreatic cancer MiaPaCa-2 cells by RUNX2 depletion-mediated augmentation of TAp73-dependent cell death.Contrasting effects of an Mdm2 functional polymorphism on tumor phenotypes.CRISPR-Cas9-based target validation for p53-reactivating model compounds.Cytoplasmic E3 ubiquitin ligase CUL9 controls cell proliferation, senescence, apoptosis and genome integrity through p53.Ubiquitylation at the crossroads of development and disease.A novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo.Loss of digestive organ expansion factor (Diexf) reveals an essential role during murine embryonic development that is independent of p53.Elucidating the rapid action of 2-(2-chlorophenyl)ethylbiguanide on HT-29 cells under a serum- and glucose-deprived condition.Post-translational regulation of p53 function through 20S proteasome-mediated cleavage.CB002, a novel p53 tumor suppressor pathway-restoring small molecule induces tumor cell death through the pro-apoptotic protein NOXA.Atf3 deficiency promotes genome instability and spontaneous tumorigenesis in mice.Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer.

P2860

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P2860

Limiting the power of p53 through the ubiquitin proteasome pathway.

http://www.wikidata.org/entity/Q34342940

description

2014 nî lūn-bûn

@nan

2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Limiting the power of p53 through the ubiquitin proteasome pathway.

@ast

Limiting the power of p53 through the ubiquitin proteasome pathway.

@en

Limiting the power of p53 through the ubiquitin proteasome pathway.

@nl

type

label

Limiting the power of p53 through the ubiquitin proteasome pathway.

@ast

Limiting the power of p53 through the ubiquitin proteasome pathway.

@en

Limiting the power of p53 through the ubiquitin proteasome pathway.

@nl

prefLabel

Limiting the power of p53 through the ubiquitin proteasome pathway.

@ast

Limiting the power of p53 through the ubiquitin proteasome pathway.

@en

Limiting the power of p53 through the ubiquitin proteasome pathway.

@nl

P1433

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P2860

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P1433

Genes & Development

P1476

Limiting the power of p53 through the ubiquitin proteasome pathway.

@en

P2093

Guillermina Lozano

http://www.w3.org/2001/XMLSchema#string

Vinod Pant

http://www.w3.org/2001/XMLSchema#string

P2860

Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

USP10 regulates p53 localization and stability by deubiquitinating p53

Regulation of p53 stability and function by the deubiquitinating enzyme USP42

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.

Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2

The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53

TRIM24 links a non-canonical histone signature to breast cancer

P304

1739-1751

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P31

scholarly article

P356

10.1101/GAD.247452.114

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P433

16

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P478

28

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P577

2014-08-01T00:00:00Z

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P5875

264830592

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P698

25128494

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ubiquitin-proteasome system

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4197966

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