Hyperactive sleeping beauty transposase enables persistent phenotypic correction in mice and a canine model for hemophilia B. - Wikidata - awgldk - TriplyDB

Hyperactive sleeping beauty transposase enables persistent phenotypic correction in mice and a canine model for hemophilia B.

Hyperactive sleeping beauty transposase enables persistent phenotypic correction in mice and a canine model for hemophilia B.

http://www.wikidata.org/entity/Q34343757

about

The Sleeping Beauty transposon system: a non-viral vector for gene therapy Gene therapy for hemophilia DNA transposon-based gene vehicles - scenes from an evolutionary drive Cell-free transmission of human adenovirus by passive mass transfer in cell culture simulated in a computer model.Adenoviral Vectors for Hemophilia Gene Therapy Inhibition of angiogenesis and suppression of colorectal cancer metastatic to the liver using the Sleeping Beauty Transposon System Genetic therapies for cystic fibrosis lung disease Hybrid adeno-associated viral vectors utilizing transposase-mediated somatic integration for stable transgene expression in human cells.piggyBac-mediated phenotypic correction of factor VIII deficiency Mobilization of DNA transposable elements from lentiviral vectors.Hybrid nonviral/viral vector systems for improved piggyBac DNA transposon in vivo delivery Retargeting transposon insertions by the adeno-associated virus Rep protein.A Hyperactive Transposase Promotes Persistent Gene Transfer of a piggyBac DNA Transposon Integration profile and safety of an adenovirus hybrid-vector utilizing hyperactive sleeping beauty transposase for somatic integration.An Efficient Electroporation Protocol for the Genetic Modification of Mammalian Cells.The expanding universe of transposon technologies for gene and cell engineering.The Sleeping Beauty transposon system for clinical applications.Recent developments in transposon-mediated gene therapy.Adenoviruses as gene/vaccine delivery vectors: promises and pitfalls.Small-size recombinant adenoviral hexon protein fragments for the production of virus-type specific antibodies.Standard free droplet digital polymerase chain reaction as a new tool for the quality control of high-capacity adenoviral vectors in small-scale preparations.Modeling correction of severe urea cycle defects in the growing murine liver using a hybrid recombinant adeno-associated virus/piggyBac transposase gene delivery system.Sleeping Beauty transposition: from biology to applications.Going non-viral: the Sleeping Beauty transposon system breaks on through to the clinical side.Gene therapy with helper-dependent adenoviral vectors: lessons from studies in large animal models.In Vivo Hematopoietic Stem Cell Transduction.Prolonged Expression of Secreted Enzymes in Dogs After Liver-Directed Delivery of Sleeping Beauty Transposons: Implications for Non-Viral Gene Therapy of Systemic Disease.A Novel Adenoviral Hybrid-vector System Carrying a Plasmid Replicon for Safe and Efficient Cell and Gene Therapeutic Applications.A High-Capacity Adenoviral Hybrid Vector System Utilizing the Hyperactive Sleeping Beauty Transposase SB100X for Enhanced Integration.Preclinical and clinical advances in transposon-based gene therapy.Constitutive and Inducible Systems for Genetic In Vivo Modification of Mouse Hepatocytes Using Hydrodynamic Tail Vein Injection.Widespread airway distribution and short-term phenotypic correction of cystic fibrosis pigs following aerosol delivery of piggyBac/adenovirus Human adenovirus type 17 from species D transduces endothelial cells and human CD46 is involved in cell entry

P2860

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P2860

Hyperactive sleeping beauty transposase enables persistent phenotypic correction in mice and a canine model for hemophilia B.

http://www.wikidata.org/entity/Q34343757

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

@zh-hk

2010年論文

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2010年論文

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2010年论文

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name

Hyperactive sleeping beauty tr ...... canine model for hemophilia B.

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Hyperactive sleeping beauty tr ...... canine model for hemophilia B.

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Hyperactive sleeping beauty tr ...... canine model for hemophilia B.

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type

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Hyperactive sleeping beauty tr ...... canine model for hemophilia B.

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Hyperactive sleeping beauty tr ...... canine model for hemophilia B.

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Hyperactive sleeping beauty tr ...... canine model for hemophilia B.

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Hyperactive sleeping beauty tr ...... canine model for hemophilia B.

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Hyperactive sleeping beauty tr ...... canine model for hemophilia B.

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Hyperactive sleeping beauty tr ...... canine model for hemophilia B.

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Molecular Therapy

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Hyperactive sleeping beauty tr ...... canine model for hemophilia B.

@en

P2093

Anja Ehrhardt

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Christina Rauschhuber

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Elizabeth P Merricks

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Helen G Franck

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Mark A Kay

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Martin A Hausl

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Nadine Müther

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Timothy C Nichols

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Wenli Zhang

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P2860

Genome sequence, comparative analysis and haplotype structure of the domestic dog

Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vector

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

High-resolution genome-wide mapping of transposon integration in mammals.

Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

A gene-deleted adenoviral vector results in phenotypic correction of canine hemophilia B without liver toxicity or thrombocytopenia.

Helper-dependent adenoviral vectors mediate therapeutic factor VIII expression for several months with minimal accompanying toxicity in a canine model of severe hemophilia A.

Helper-dependent adenoviral gene therapy mediates long-term correction of the clotting defect in the canine hemophilia A model.

Modulation of TNFalpha, a determinant of acute toxicity associated with systemic delivery of first-generation and helper-dependent adenoviral vectors.

P304

1896-1906

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scholarly article

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10.1038/MT.2010.169

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11

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18

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2010-08-17T00:00:00Z

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45695131

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20717103

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2990515

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