Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels
about
Mechanically Activated Ion ChannelsMammalian touch catches upThe changing landscape of membrane protein structural biology through developments in electron microscopy.Piezo1, a mechanically activated ion channel, is required for vascular development in mice.Evidence for shear-mediated Ca2+ entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line.Stretch-activated channel Piezo1 is up-regulated in failure heart and cardiomyocyte stimulated by AngII.Fundamentals of nanoscale polymer-protein interactions and potential contributions to solid-state nanobioarraysThe structure of a conserved piezo channel domain reveals a topologically distinct β sandwich foldPiezo proteins: regulators of mechanosensation and other cellular processesProtonation of the human PIEZO1 ion channel stabilizes inactivationIonic Selectivity and Permeation Properties of Human PIEZO1 Channels.Piezo1 links mechanical forces to red blood cell volumeChemical activation of the mechanotransduction channel Piezo1Piezo1 ion channel pore properties are dictated by C-terminal region.An alternative to force.Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides.Human PIEZO1 Ion Channel Functions as a Split ProteinMutations in the Gardos channel (KCNN4) are associated with hereditary xerocytosis.Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis.Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia.Piezo1 regulates mechanotransductive release of ATP from human RBCs.Diagnostic tool for red blood cell membrane disorders: Assessment of a new generation ektacytometerSlower Piezo1 inactivation in dehydrated hereditary stomatocytosis (xerocytosis)Human PIEZO1: removing inactivation.Applications of high-throughput DNA sequencing to benign hematologyRed blood cell vesiculation in hereditary hemolytic anemia.Disorders of erythrocyte volume homeostasis.Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension.Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels.Piezo1 plays a role in erythrocyte volume homeostasis.Recommendations regarding splenectomy in hereditary hemolytic anemias.Is Increased Intracellular Calcium in Red Blood Cells a Common Component in the Molecular Mechanism Causing Anemia?Investigating the structural dynamics of the PIEZO1 channel activation and inactivation by coarse-grained modeling.Hereditary Xerocytosis due to Mutations in PIEZO1 Gene Associated with Heterozygous Pyruvate Kinase Deficiency and Beta-Thalassemia Trait in Two Unrelated Families.Red blood cell Gardos channel (KCNN4): the essential determinant of erythrocyte dehydration in hereditary xerocytosisTransduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels.Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension.Hereditary xerocytosis revisitedHomozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia.Weighted likelihood inference of genomic autozygosity patterns in dense genotype data.
P2860
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P2860
Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Dehydrated hereditary stomatoc ...... activated PIEZO1 ion channels
@ast
Dehydrated hereditary stomatoc ...... activated PIEZO1 ion channels
@en
Dehydrated hereditary stomatoc ...... activated PIEZO1 ion channels
@nl
type
label
Dehydrated hereditary stomatoc ...... activated PIEZO1 ion channels
@ast
Dehydrated hereditary stomatoc ...... activated PIEZO1 ion channels
@en
Dehydrated hereditary stomatoc ...... activated PIEZO1 ion channels
@nl
prefLabel
Dehydrated hereditary stomatoc ...... activated PIEZO1 ion channels
@ast
Dehydrated hereditary stomatoc ...... activated PIEZO1 ion channels
@en
Dehydrated hereditary stomatoc ...... activated PIEZO1 ion channels
@nl
P2093
P2860
P356
P1476
Dehydrated hereditary stomatoc ...... activated PIEZO1 ion channels
@en
P2093
Ardem Patapoutian
Bertrand Coste
Fabienne Toutain
Gérard Tertian
Hélène Louis-Dit-Picard
Jayanti Mathur
Jean Delaunay
Jean-Pierre de Jaureguiberry
Juliette Albuisson
Loic Garçon
P2860
P2888
P356
10.1038/NCOMMS2899
P407
P577
2013-01-01T00:00:00Z
P5875
P6179
1015159942