Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.

Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.

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http://www.wikidata.org/entity/Q34352043
The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related GenesStanniocalcin 2 is a negative modulator of store-operated calcium entryAftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease?Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator.Curcumin induces cell death in esophageal cancer cells through modulating Notch signalingDifferential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs.3,5-bis(2,4-difluorobenzylidene)-4-piperidone, a novel compound that affects pancreatic cancer growth and angiogenesisTransgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in miceNovel GαS-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain.Ca2+ influx through store-operated Ca2+ channels reduces Alzheimer disease β-amyloid peptide secretion.Polar transmembrane-based amino acids in presenilin 1 are involved in endoplasmic reticulum localization, Pen2 protein binding, and γ-secretase complex stabilizationS-acylation of SOD1, CCS, and a stable SOD1-CCS heterodimer in human spinal cords from ALS and non-ALS subjects.Allosteric Modulation of Intact γ-Secretase Structural Dynamics.Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.p.Thr116Ile Variant in Two Korean Families with Young Onset Alzheimer's Disease
P2860

Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.

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http://www.wikidata.org/entity/Q34352043
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Mutation analysis of the prese ...... protein and other substrates.
@ast
Mutation analysis of the prese ...... protein and other substrates.
@en
Mutation analysis of the prese ...... protein and other substrates.
@nl
type
label
Mutation analysis of the prese ...... protein and other substrates.
@ast
Mutation analysis of the prese ...... protein and other substrates.
@en
Mutation analysis of the prese ...... protein and other substrates.
@nl
prefLabel
Mutation analysis of the prese ...... protein and other substrates.
@ast
Mutation analysis of the prese ...... protein and other substrates.
@en
Mutation analysis of the prese ...... protein and other substrates.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932
P356
P1433
P1476
Mutation analysis of the prese ...... protein and other substrates.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932