Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity. - Wikidata - awgldk - TriplyDB

Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity.

Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity.

http://www.wikidata.org/entity/Q34352217

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Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes High glucose-mediated oxidative stress impairs cell migration.Mechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells Control of mTORC1 signaling by the Opitz syndrome protein MID1.Mammalian target of rapamycin complex 2 (mTORC2) is a critical determinant of bladder cancer invasion S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation.Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2.SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis.Review series: TOR kinase complexes and cell migration.Cryptotanshinone inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3/ERK and small GTPase pathways Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion.Inhibition of chemokine (CXC motif) ligand 12/chemokine (CXC motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells.Rapamycin inhibits lymphatic endothelial cell tube formation by downregulating vascular endothelial growth factor receptor 3 protein expression.Rapamycin prevents cadmium-induced neuronal cell death via targeting both mTORC1 and mTORC2 pathways Insulin-like growth factor-1 (IGF-1) inhibits the basolateral Cl channels in the thick ascending limb of the rat kidney.Evolutionary trends and functional anatomy of the human expanded autophagy network.Celastrol ameliorates Cd-induced neuronal apoptosis by targeting NOX2-derived ROS-dependent PP5-JNK signaling pathway.Neuritic complexity of hippocampal neurons depends on WIP-mediated mTORC1 and Abl family kinases activities Rapamycin inhibits Erk1/2-mediated neuronal apoptosis caused by cadmium.Molecular evidence of cryptotanshinone for treatment and prevention of human cancer Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-β.NFAT5 represses canonical Wnt signaling via inhibition of β-catenin acetylation and participates in regulating intestinal cell differentiation.Dihydroartemisinin inhibits the mammalian target of rapamycin-mediated signaling pathways in tumor cells Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy.Current development of the second generation of mTOR inhibitors as anticancer agents.mTOR kinase inhibitors as a treatment strategy in hematological malignancies.Therapeutic targeting of the mTOR-signalling pathway in cancer: benefits and limitations RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.Flavone inhibits migration through DLC1/RhoA pathway by decreasing ROS generation in breast cancer cells.Rapamycin attenuates BAFF-extended proliferation and survival via disruption of mTORC1/2 signaling in normal and neoplastic B-lymphoid cells.mTOR regulate EMT through RhoA and Rac1 pathway in prostate cancer.Celastrol Attenuates Cadmium-Induced Neuronal Apoptosis via Inhibiting Ca2+ -CaMKII-Dependent Akt/mTOR Pathway.mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways.Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex.Celastrol prevents cadmium-induced neuronal cell death by blocking reactive oxygen species-mediated mammalian target of rapamycin pathway.Rapamycin inhibits BAFF-stimulated cell proliferation and survival by suppressing mTOR-mediated PP2A-Erk1/2 signaling pathway in normal and neoplastic B-lymphoid cells.Inhibition of PI3K/Akt/mTOR signaling by natural products.A deut of mTORC1/2 for cell adhesion.Dual TORCs driven and B56 orchestrated signaling network guides eukaryotic cell migration.TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis.

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P2860

Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity.

http://www.wikidata.org/entity/Q34352217

description

2010 nî lūn-bûn

@nan

2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Rapamycin inhibits cytoskeleto ...... RhoA expression and activity.

@ast

Rapamycin inhibits cytoskeleto ...... RhoA expression and activity.

@en

Rapamycin inhibits cytoskeleto ...... RhoA expression and activity.

@nl

type

label

Rapamycin inhibits cytoskeleto ...... RhoA expression and activity.

@ast

Rapamycin inhibits cytoskeleto ...... RhoA expression and activity.

@en

Rapamycin inhibits cytoskeleto ...... RhoA expression and activity.

@nl

prefLabel

Rapamycin inhibits cytoskeleto ...... RhoA expression and activity.

@ast

Rapamycin inhibits cytoskeleto ...... RhoA expression and activity.

@en

Rapamycin inhibits cytoskeleto ...... RhoA expression and activity.

@nl

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JBC.M110.141168

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Journal of Biological Chemistry

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Rapamycin inhibits cytoskeleto ...... g RhoA expression and activity

@en

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Hongyu Zhou

http://www.w3.org/2001/XMLSchema#string

Long Chen

http://www.w3.org/2001/XMLSchema#string

Tao Shen

http://www.w3.org/2001/XMLSchema#string

Wenxing Chen

http://www.w3.org/2001/XMLSchema#string

Xiuzhen Han

http://www.w3.org/2001/XMLSchema#string

Yan Luo

http://www.w3.org/2001/XMLSchema#string

P2860

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

Integrin-regulated FAK-Src signaling in normal and cancer cells

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

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