Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity. - Wikidata - awgldk - TriplyDB

Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity.

Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity.

http://www.wikidata.org/entity/Q34354902

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Positive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatment Antibodies to probe endogenous G protein-coupled receptor heteromer expression, regulation, and function Biological redundancy of endogenous GPCR ligands in the gut and the potential for endogenous functional selectivity Preferred supramolecular organization and dimer interfaces of opioid receptors from simulated self-association Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity Putative kappa opioid heteromers as targets for developing analgesics free of adverse effects.Pharmacologic characterization in the rat of a potent analgesic lacking respiratory depression, IBNtxA.Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR review 10.Heteromers of μ-δ opioid receptors: new pharmacology and novel therapeutic possibilities.Analgesic synergy between opioid and α2 -adrenoceptors Recent advances on the δ opioid receptor: from trafficking to function.In vivo opioid receptor heteromerization: where do we stand?A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks.In vivo neuronal co-expression of mu and delta opioid receptors uncovers new therapeutic perspectives.Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx.Impact of Lipid Composition and Receptor Conformation on the Spatio-temporal Organization of μ-Opioid Receptors in a Multi-component Plasma Membrane Model.β-Arrestin 2 dependence of δ opioid receptor agonists is correlated with alcohol intake.G Protein-Coupled Receptor Heteromers.Recent progress in neuroactive marine natural products.G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives.Challenges for opioid receptor nomenclature: IUPHAR Review 9.Molecular Perspectives for mu/delta Opioid Receptor Heteromers as Distinct, Functional Receptors The use of opioids for treatment of cancer pain.Molecular characterization of eluxadoline as a potential ligand targeting mu-delta opioid receptor heteromers.Contribution of heteromerization to G protein-coupled receptor function.Novel Molecular Strategies and Targets for Opioid Drug Discovery for the Treatment of Chronic Pain.Insights into the function of opioid receptors from molecular dynamics simulations of available crystal structures.Targeting multiple opioid receptors - improved analgesics with reduced side effects?The Delta Opioid Receptor in Pain Control.Asymmetric synthesis and in vitro and in vivo activity of tetrahydroquinolines featuring a diverse set of polar substitutions at the 6 position as mixed-efficacy μ opioid receptor/δ opioid receptor ligands.Endothelin-converting enzyme 2 differentially regulates opioid receptor activity.G protein-coupled receptors: a double attack on pain.Identification of selective agonists and positive allosteric modulators for µ- and δ-opioid receptors from a single high-throughput screen.Two delta opioid receptor subtypes are functional in single ventral tegmental area neurons, and can interact with the mu opioid receptor.NPYFa, A Chimeric Peptide of Met-Enkephalin, and NPFF Induces Tolerance-Free Analgesia.Detection of Receptor Heteromerization Using In Situ Proximity Ligation Assay.Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits.

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P2860

Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity.

http://www.wikidata.org/entity/Q34354902

description

2013 nî lūn-bûn

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2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հուլիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Identification of a μ-δ opioid ...... with antinociceptive activity.

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Identification of a μ-δ opioid ...... with antinociceptive activity.

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Identification of a μ-δ opioid ...... with antinociceptive activity.

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Identification of a μ-δ opioid ...... with antinociceptive activity.

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Identification of a μ-δ opioid ...... with antinociceptive activity.

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Identification of a μ-δ opioid ...... with antinociceptive activity.

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Identification of a μ-δ opioid ...... with antinociceptive activity.

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Identification of a μ-δ opioid ...... with antinociceptive activity.

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Proceedings of the National Academy of Sciences of the United States of America

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Identification of a μ-δ opioid ...... with antinociceptive activity.

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Achla Gupta

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Christina Eberhart

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Christine E Pinello

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Edward Roberts

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Ivone Gomes

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Lakshmi A Devi

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S Adrian Saldanha

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Wakako Fujita

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P2860

The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors

Standard opioid agonists activate heteromeric opioid receptors: evidence for morphine and [d-Ala(2)-MePhe(4)-Glyol(5)]enkephalin as selective μ-δ agonists

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

jCompoundMapper: An open source Java library and command-line tool for chemical fingerprints

Automatic generation of 3D-atomic coordinates for organic molecules

Heterodimerization of mu and delta opioid receptors: A role in opiate synergy

Enhanced morphine analgesia in mice lacking beta-arrestin 2

Receptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimers

Similarity-potency trees: a method to search for SAR information in compound data sets and derive SAR rules.

Chronic morphine alters the presynaptic protein profile: identification of novel molecular targets using proteomics and network analysis

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