Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents - Wikidata - awgldk - TriplyDB

Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents

Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents

http://www.wikidata.org/entity/Q34358718

about

Targeting histone deacetylases for cancer therapy: from molecular mechanisms to clinical implications Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells Development of a histone deacetylase 6 inhibitor and its biological effects Histone deacetylase 10 regulates DNA mismatch repair and may involve the deacetylation of MutS homolog 2.Histone deacetylase classes I and II regulate Kaposi's sarcoma-associated herpesvirus reactivation.Enhanced non-viral gene delivery by coordinated endosomal release and inhibition of β-tubulin deactylase.Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells.Histone deacetylase inhibitor (HDACI) mechanisms of action: emerging insights.A novel class of small molecule inhibitors of HDAC6.PI3K/mTOR inhibition markedly potentiates HDAC inhibitor activity in NHL cells through BIM- and MCL-1-dependent mechanisms in vitro and in vivo.New insights into the treatment of multiple myeloma with histone deacetylase inhibitors.Utilization of the cellular stress response to sensitize cancer cells to TRAIL-mediated apoptosis.HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα.Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancer 3-Hydroxypyridin-2-thione as novel zinc binding group for selective histone deacetylase inhibition.Depletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cells Misfolded proteins: from little villains to little helpers in the fight against cancer.Copy-number variation of cancer-gene orthologs is sufficient to induce cancer-like symptoms in Saccharomyces cerevisiae.Functional relevance of the histone gammaH2Ax in the response to DNA damaging agents.Syntheses and discovery of a novel class of cinnamic hydroxamates as histone deacetylase inhibitors by multimodality molecular imaging in living subjects.Augmenting antitumor immune responses with epigenetic modifying agents.Biomarkers of histone deacetylase inhibitor activity in a phase 1 combined-modality study with radiotherapy.Epigenetic therapy for breast cancer.Potential non-oncological applications of histone deacetylase inhibitors.Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), enhances anti-tumor effects of the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib in triple-negative breast cancer cells.Preclinical antitumor activity of ST7612AA1: a new oral thiol-based histone deacetylase (HDAC) inhibitor.Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma Tubulin Beta3 Serves as a Target of HDAC3 and Mediates Resistance to Microtubule-Targeting Drugs.Creation of a histone deacetylase 6 inhibitor and its biological effects [corrected].Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells.Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation HDAC6 activity is not required for basal autophagic flux in metastatic prostate cancer cells.The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity.HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates SNP rs10248565 in HDAC9 as a novel genomic aberration biomarker of lung adenocarcinoma in non-smoking women.γH2Ax: biomarker of damage or functional participant in DNA repair "all that glitters is not gold!".Screening for compounds that modulate epigenetic regulation of the transcriptome: an overview.Histone deacetylases and their role in asthma.Developing histone deacetylase inhibitors in the therapeutic armamentarium of pancreatic adenocarcinoma.

P2860

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P2860

Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents

http://www.wikidata.org/entity/Q34358718

description

2010 nî lūn-bûn

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2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Selective inhibition of histon ...... med cells to anticancer agents

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Selective inhibition of histon ...... med cells to anticancer agents

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Selective inhibition of histone deacetylase 6

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type

label

Selective inhibition of histon ...... med cells to anticancer agents

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Selective inhibition of histon ...... med cells to anticancer agents

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Selective inhibition of histone deacetylase 6

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prefLabel

Selective inhibition of histon ...... med cells to anticancer agents

@ast

Selective inhibition of histon ...... med cells to anticancer agents

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Selective inhibition of histone deacetylase 6

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Proceedings of the National Academy of Sciences of the United States of America

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Selective inhibition of histon ...... med cells to anticancer agents

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P2093

Gisela Perez

http://www.w3.org/2001/XMLSchema#string

Lang Ngo

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Mandana Namdar

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Paul A Marks

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P2860

Induction of a cell stress response gene RTP801 by DNA damaging agent methyl methanesulfate through CCAA/enhancer binding protein

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

HDAC6 is a microtubule-associated deacetylase

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination

Lysine acetylation targets protein complexes and co-regulates major cellular functions

Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug

HDAC6-p97/VCP controlled polyubiquitin chain turnover

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107

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21037108

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