Pregnane X receptor and constitutive androstane receptor at the crossroads of drug metabolism and energy metabolism. - Wikidata - awgldk - TriplyDB

Pregnane X receptor and constitutive androstane receptor at the crossroads of drug metabolism and energy metabolism.

Pregnane X receptor and constitutive androstane receptor at the crossroads of drug metabolism and energy metabolism.

http://www.wikidata.org/entity/Q34359458

about

The retinoid X receptors and their ligands Pharmacokinetic and Metabolic Characteristics of Herb-Derived Khellactone Derivatives, A Class of Anti-HIV and Anti-Hypertensive: A Review Biology of PXR: role in drug-hormone interactions Pregnane X receptor as a target for treatment of inflammatory bowel disorders Evaluation of Aroclor 1260 exposure in a mouse model of diet-induced obesity and non-alcoholic fatty liver disease Glucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase.Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor.Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice.Annotation of the Daphnia magna nuclear receptors: comparison to Daphnia pulex HIV-1 infection is associated with changes in nuclear receptor transcriptome, pro-inflammatory and lipid profile of monocytes.Impairment of bilirubin clearance and intestinal interleukin-6 expression in bile duct-ligated vitamin D receptor null mice Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.Alteration of hepatic but not renal transporter expression in diet-induced obese mice Multi-species analyses of direct activators of the constitutive androstane receptor.GW4064, an agonist of farnesoid X receptor, represses CYP3A4 expression in human hepatocytes by inducing small heterodimer partner expression.Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium Quantitative high-throughput identification of drugs as modulators of human constitutive androstane receptor.Daphnia HR96 is a promiscuous xenobiotic and endobiotic nuclear receptor Bioinformatic analysis of microRNA networks following the activation of the constitutive androstane receptor (CAR) in mouse liver Estradiol induces cytochrome P450 2B6 expression at high concentrations: implication in estrogen-mediated gene regulation in pregnancy.Role of nuclear receptors in lipid dysfunction and obesity-related diseases.Molecular Interactions between NAFLD and Xenobiotic Metabolism.Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation.PXR ablation alleviates diet-induced and genetic obesity and insulin resistance in mice.Long-term exposure to abnormal glucose levels alters drug metabolism pathways and insulin sensitivity in primary human hepatocytes.Drug metabolism alterations in nonalcoholic fatty liver disease Pregnane X Receptor and Cancer: Context-Specificity is Key.PXR-Mediated Upregulation of CYP3A Expression by Herb Compound Praeruptorin C from Peucedanum praeruptorum Dunn.Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes.Role of pregnane X receptor in obesity and glucose homeostasis in male mice.Xenobiotic receptor humanized mice and their utility.Nuclear receptors and endobiotics glucuronidation: the good, the bad, and the UGT.Circadian events in human diseases and in cytochrome P450-related drug metabolism and therapy.Med1 subunit of the mediator complex in nuclear receptor-regulated energy metabolism, liver regeneration, and hepatocarcinogenesis A SUMO-acetyl switch in PXR biology.Activation of the constitutive androstane receptor inhibits gluconeogenesis without affecting lipogenesis or fatty acid synthesis in human hepatocytes.Cellular impact of combinations of endosulfan, atrazine, and chlorpyrifos on human primary hepatocytes and HepaRG cells after short and chronic exposures.The transcription factor Maf-S regulates metabolic resistance to insecticides in the malaria vector Anopheles gambiae.Functions of pregnane X receptor in self-detoxification.

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P2860

Pregnane X receptor and constitutive androstane receptor at the crossroads of drug metabolism and energy metabolism.

http://www.wikidata.org/entity/Q34359458

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Pregnane X receptor and consti ...... abolism and energy metabolism.

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Pregnane X receptor and consti ...... abolism and energy metabolism.

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Pregnane X receptor and consti ...... abolism and energy metabolism.

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Pregnane X receptor and consti ...... abolism and energy metabolism.

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Pregnane X receptor and consti ...... abolism and energy metabolism.

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Pregnane X receptor and consti ...... abolism and energy metabolism.

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Pregnane X receptor and consti ...... abolism and energy metabolism.

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Drug Metabolism and Disposition

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Pregnane X receptor and consti ...... abolism and energy metabolism.

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P2093

Jie Gao

http://www.w3.org/2001/XMLSchema#string

Wen Xie

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P2860

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line

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2091-2095

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scholarly article

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10.1124/DMD.110.035568

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12

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38

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2010-08-24T00:00:00Z

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20736325

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2993451

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