The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels
about
Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a poChronic cocaine disrupts mesocortical learning mechanismsPotent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitusPathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus.KCNQ5 channels control resting properties and release probability of a synapseKCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two stepsThe slow afterhyperpolarization: a target of β1-adrenergic signaling in hippocampus-dependent memory retrieval.Computational modeling reveals key contributions of KCNQ and hERG currents to the malleability of uterine action potentials underpinning labor.Hippocalcin and KCNQ channels contribute to the kinetics of the slow afterhyperpolarization.Novel Roles for Kv7 Channels in Shaping Histamine-Induced Contractions and Bradykinin-Dependent Relaxations in Pig Coronary Arteries.What determines the kinetics of the slow afterhyperpolarization (sAHP) in neurons?The Voltage Activation of Cortical KCNQ Channels Depends on Global PIP2 Levels.Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1Kisspeptin inhibits a slow afterhyperpolarization current via protein kinase C and reduces spike frequency adaptation in GnRH neurons.Hypocretin/Orexin Peptides Alter Spike Encoding by Serotonergic Dorsal Raphe Neurons through Two Distinct Mechanisms That Increase the Late AfterhyperpolarizationDiscovery of a retigabine derivative that inhibits KCNQ2 potassium channels.The calcium-activated slow AHP: cutting through the Gordian knot.Calcium influx through N-type channels and activation of SK and TRP-like channels regulates tonic firing of neurons in rat paraventricular thalamus.Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators.Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation
P2860
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P2860
The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The specific slow afterhyperpo ...... lepsy associated KCNQ channels
@ast
The specific slow afterhyperpo ...... lepsy associated KCNQ channels
@en
The specific slow afterhyperpo ...... lepsy associated KCNQ channels
@nl
type
label
The specific slow afterhyperpo ...... lepsy associated KCNQ channels
@ast
The specific slow afterhyperpo ...... lepsy associated KCNQ channels
@en
The specific slow afterhyperpo ...... lepsy associated KCNQ channels
@nl
prefLabel
The specific slow afterhyperpo ...... lepsy associated KCNQ channels
@ast
The specific slow afterhyperpo ...... lepsy associated KCNQ channels
@en
The specific slow afterhyperpo ...... lepsy associated KCNQ channels
@nl
P2860
P356
P1476
The specific slow afterhyperpo ...... lepsy associated KCNQ channels
@en
P2093
Anastassios V Tzingounis
P2860
P304
P356
10.1124/MOL.110.066100
P577
2010-09-15T00:00:00Z