Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognition.
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Molecular insight into substrate recognition by human cytosolic sialidase NEU2Neuraminidase-1, a subunit of the cell surface elastin receptor, desialylates and functionally inactivates adjacent receptors interacting with the mitogenic growth factors PDGF-BB and IGF-2The Structure of Clostridium perfringens NanI Sialidase and Its Catalytic IntermediatesA new generation of specific Trypanosoma cruzi trans-sialidase inhibitorsMolecular Basis of Arabinobio-hydrolase Activity in Phytopathogenic Fungi: CRYSTAL STRUCTURE AND CATALYTIC MECHANISM OF FUSARIUM GRAMINEARUM GH93 EXO- -L-ARABINANASEThe Aspergillus fumigatus Sialidase Is a 3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid Hydrolase (KDNase): STRUCTURAL AND MECHANISTIC INSIGHTSCrystal structures of apparent saccharide sensors from histidine kinase receptors prevalent in a human gut symbiontTuning mechanism-based inactivators of neuraminidases: mechanistic and structural insightsNeuraminidase-1: a novel therapeutic target in multistage tumorigenesisIn silico identification of new putative pathogenic variants in the NEU1 sialidase gene affecting enzyme function and subcellular localizationMetabolism of vertebrate amino sugars with N-glycolyl groups: resistance of α2-8-linked N-glycolylneuraminic acid to enzymatic cleavageCo-Expression of NEU2 and GBA3 Causes a Drastic Reduction in Cytosolic Sialyl Free N-glycans in Human MKN45 Stomach Cancer Cells-Evidence for the Physical Interaction of NEU2 and GBA3Interface dynamics explain assembly dependency of influenza neuraminidase catalytic activity.A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir.Gallus gallus NEU3 sialidase as model to study protein evolution mechanism based on rapid evolving loops.Sequence and structural analysis of the Asp-box motif and Asp-box beta-propellers; a widespread propeller-type characteristic of the Vps10 domain family and several glycoside hydrolase familiesThymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9.Structural basis of sialidase in complex with geranylated flavonoids as potent natural inhibitors.A strategy for neuraminidase inhibitors using mechanism-based labeling information.The impact of the butterfly effect on human parainfluenza virus haemagglutinin-neuraminidase inhibitor design.New insights on the sialidase protein family revealed by a phylogenetic analysis in metazoa.Structural basis for substrate specificity of mammalian neuraminidases.Anti-influenza neuraminidase inhibitor oseltamivir phosphate induces canine mammary cancer cell aggressiveness.Fluorogenic sialic acid glycosides for quantification of sialidase activity upon unnatural substrates.Insights into the activity and specificity of Trypanosoma cruzi trans-sialidase from molecular dynamics simulationsAssessment of neuropsychiatric adverse events in influenza patients treated with oseltamivir: a comprehensive review.Aberrant expression of sialidase and cancer progression.Glycoside hydrolases: catalytic base/nucleophile diversity.The chemistry and biology of trypanosomal trans-sialidases: virulence factors in Chagas disease and sleeping sickness.Sialidase significance for cancer progression.Implications for the mammalian sialidases in the physiopathology of skeletal muscleA novel alpha-glucosidase from the acidophilic archaeon Ferroplasma acidiphilum strain Y with high transglycosylation activity and an unusual catalytic nucleophile.Desialylation of dying cells with catalytically active antibodies possessing sialidase activity facilitate their clearance by human macrophages.The NEU1-selective sialidase inhibitor, C9-butyl-amide-DANA, blocks sialidase activity and NEU1-mediated bioactivities in human lung in vitro and murine lung in vivo.Identification of Selective Nanomolar Inhibitors of the Human Neuraminidase, NEU4Limited inhibitory effects of oseltamivir and zanamivir on human sialidasesAntibody against Microbial Neuraminidases Recognizes Human Sialidase 3 (NEU3): the Neuraminidase/Sialidase Superfamily Revisited.Human Sialidase Neu3 is S-Acylated and Behaves Like an Integral Membrane Protein.Streptococcus pneumoniae NanC: STRUCTURAL INSIGHTS INTO THE SPECIFICITY AND MECHANISM OF A SIALIDASE THAT PRODUCES A SIALIDASE INHIBITOR.Molecular cloning and biochemical characterization of sialidases from zebrafish (Danio rerio).
P2860
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P2860
Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognition.
description
2004 nî lūn-bûn
@nan
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Crystal structure of the human ...... ture of substrate recognition.
@ast
Crystal structure of the human ...... ture of substrate recognition.
@en
Crystal structure of the human ...... ture of substrate recognition.
@nl
type
label
Crystal structure of the human ...... ture of substrate recognition.
@ast
Crystal structure of the human ...... ture of substrate recognition.
@en
Crystal structure of the human ...... ture of substrate recognition.
@nl
prefLabel
Crystal structure of the human ...... ture of substrate recognition.
@ast
Crystal structure of the human ...... ture of substrate recognition.
@en
Crystal structure of the human ...... ture of substrate recognition.
@nl
P2093
P356
P1476
Crystal structure of the human ...... ture of substrate recognition.
@en
P2093
Bruno Venerando
Eugenio Monti
Guido Tettamanti
Leonard M G Chavas
Paola Fusi
Ryuichi Kato
Soichi Wakatsuki
P304
P356
10.1074/JBC.M411506200
P407
P577
2004-10-22T00:00:00Z