Pentamidine inhibits mitochondrial intron splicing and translation in Saccharomyces cerevisiae. - Wikidata - awgldk - TriplyDB

Pentamidine inhibits mitochondrial intron splicing and translation in Saccharomyces cerevisiae.

Pentamidine inhibits mitochondrial intron splicing and translation in Saccharomyces cerevisiae.

http://www.wikidata.org/entity/Q34362783

about

Pentamidine binds to tRNA through non-specific hydrophobic interactions and inhibits aminoacylation and translation Multiple interactions involving the amino-terminal domain of yeast mtRNA polymerase determine the efficiency of mitochondrial protein synthesis Reducing levels of toxic RNA with small molecules Identifying the preferred RNA motifs and chemotypes that interact by probing millions of combinations.Sls1p is a membrane-bound regulator of transcription-coupled processes involved in Saccharomyces cerevisiae mitochondrial gene expression.In vitro and in vivo antifungal activities of T-2307, a novel arylamidine.Synchronized mitochondrial and cytosolic translation programs.Pentamidine reverses the splicing defects associated with myotonic dystrophy.Central role of mitochondria in drug-induced liver injury.Folding of the group I intron ribozyme from the 26S rRNA gene of Candida albicans.Pentamidine inhibits catalytic activity of group I intron Ca.LSU by altering RNA folding.Antisense oligonucleotides effectively inhibit the co-transcriptional splicing of a Candida group I intron in vitro and in vivo: Implications for antifungal therapeutics.DB75, a novel trypanocidal agent, disrupts mitochondrial function in Saccharomyces cerevisiae.Pentamidine inhibits Coxiella burnetii growth and 23S rRNA intron splicing in vitro Multiple group I introns in the small-subunit rDNA of Botryosphaeria dothidea: implication for intraspecific genetic diversity.Antileishmanial Mechanism of Diamidines Involves Targeting Kinetoplasts.T-2307 causes collapse of mitochondrial membrane potential in yeast.The unusual 23S rRNA gene of Coxiella burnetii: two self-splicing group I introns flank a 34-base-pair exon, and one element lacks the canonical omegaG.Drugging tRNA aminoacylation.Small Molecules Which Improve Pathogenesis of Myotonic Dystrophy Type 1.

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P2860

Pentamidine inhibits mitochondrial intron splicing and translation in Saccharomyces cerevisiae.

http://www.wikidata.org/entity/Q34362783

description

2000 nî lūn-bûn

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2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2000 թվականի հուլիսին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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A Bell

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M J Leibowitz

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P S Perlman

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P2860

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose

Intron 5 alpha of the COXI gene of yeast mitochondrial DNA is a mobile group I intron

Crystal structure of gamma-oxapentamidine complexed with d(CGCGAATTCGCG)2. The effects of drug structural change on DNA minor-groove recognition

A latent intron-encoded maturase is also an endonuclease needed for intron mobility.

Mitochondrial protein synthesis is not required for efficient excision of intron aI5 beta from COX1 pre-mRNA in Saccharomyces cerevisiae.

Ribosomal protein L32 of Saccharomyces cerevisiae influences both the splicing of its own transcript and the processing of rRNA.

The product of the nuclear gene PET309 is required for translation of mature mRNA and stability or production of intron-containing RNAs derived from the mitochondrial COX1 locus of Saccharomyces cerevisiae

The mobile group I intron 3 alpha of the yeast mitochondrial COXI gene encodes a 35-kDa processed protein that is an endonuclease but not a maturase.

Mutations in a GTP-binding motif of eukaryotic elongation factor 1A reduce both translational fidelity and the requirement for nucleotide exchange.

Self-splicing of group I introns

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