Isoform-specific dominant-negative effects associated with hERG1 G628S mutation in long QT syndrome.
about
Position of premature termination codons determines susceptibility of hERG mutations to nonsense-mediated mRNA decay in long QT syndromeIdentification of Kv11.1 isoform switch as a novel pathogenic mechanism of long-QT syndrome.LQT2 nonsense mutations generate trafficking defective NH2-terminally truncated channels by the reinitiation of translation.Gene therapy to treat cardiac arrhythmias.Upregulation of functional Kv11.1 isoform expression by inhibition of intronic polyadenylation with antisense morpholino oligonucleotides.Upregulation of functional Kv11.1a isoform expression by modified U1 small nuclear RNA.
P2860
Isoform-specific dominant-negative effects associated with hERG1 G628S mutation in long QT syndrome.
description
2012 nî lūn-bûn
@nan
2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Isoform-specific dominant-nega ...... mutation in long QT syndrome.
@ast
Isoform-specific dominant-nega ...... mutation in long QT syndrome.
@en
Isoform-specific dominant-nega ...... mutation in long QT syndrome.
@nl
type
label
Isoform-specific dominant-nega ...... mutation in long QT syndrome.
@ast
Isoform-specific dominant-nega ...... mutation in long QT syndrome.
@en
Isoform-specific dominant-nega ...... mutation in long QT syndrome.
@nl
prefLabel
Isoform-specific dominant-nega ...... mutation in long QT syndrome.
@ast
Isoform-specific dominant-nega ...... mutation in long QT syndrome.
@en
Isoform-specific dominant-nega ...... mutation in long QT syndrome.
@nl
P2093
P2860
P1433
P1476
Isoform-specific dominant-nega ...... mutation in long QT syndrome.
@en
P2093
Matthew R Stump
Qiuming Gong
Zhengfeng Zhou
P2860
P304
P356
10.1371/JOURNAL.PONE.0042552
P407
P577
2012-08-02T00:00:00Z