Applications of Connectivity Map in drug discovery and development.
about
Network-based analysis of comorbidities risk during an infection: SARS and HIV case studiesSystems biology approaches for advancing the discovery of effective drug combinationsUsing Pharmacogenomic Databases for Discovering Patient-Target Genes and Small Molecule Candidates to Cancer TherapyAssessing Concordance of Drug-Induced Transcriptional Response in Rodent Liver and Cultured HepatocytesPrediction of Candidate Drugs for Treating Pancreatic Cancer by Using a Combined ApproachFish connectivity mapping: linking chemical stressors by their mechanisms of action-driven transcriptomic profilesComputational drug repositioning: from data to therapeutics.A network-based method for mechanistic investigation of Shexiang Baoxin Pill's treatment of cardiovascular diseases.Recovering drug-induced apoptosis subnetwork from Connectivity Map dataRelating Chemical Structure to Cellular Response: An Integrative Analysis of Gene Expression, Bioactivity, and Structural Data Across 11,000 Compounds.Toward better drug repositioning: prioritizing and integrating existing methods into efficient pipelines.The gene expression profiles in response to 102 traditional Chinese medicine (TCM) components: a general template for research on TCMsDrug repositioning for enzyme modulator based on human metabolite-likeness.Elucidating polypharmacological mechanisms of polyphenols by gene module profile analysis.A pre-clinical model of resistance to induction therapy in pediatric acute lymphoblastic leukemiaBioinformatics methods in drug repurposing for Alzheimer's disease.Target identification of small molecules based on chemical biology approaches.Systematic evaluation of connectivity map for disease indicationsProbabilistic drug connectivity mapping.Target deconvolution of bioactive small molecules: the heart of chemical biology and drug discovery.Connectivity mapping using a combined gene signature from multiple colorectal cancer datasets identified candidate drugs including existing chemotherapiesRepurposing medicinal compounds for blood cancer treatment.QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics.A gene-signature progression approach to identifying candidate small-molecule cancer therapeutics with connectivity mappingMulti-target pharmacology: possibilities and limitations of the "skeleton key approach" from a medicinal chemist perspective.High motivation for exercise is associated with altered chromatin regulators of monoamine receptor gene expression in the striatum of selectively bred mice.Connectivity Map-based discovery of parbendazole reveals targetable human osteogenic pathwayA review of connectivity map and computational approaches in pharmacogenomics.Transcriptomic profiling of human hippocampal progenitor cells treated with antidepressants and its application in drug repositioningIdentification of thiostrepton as a novel therapeutic agent that targets human colon cancer stem cells.Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders.Identifying clinically relevant drug resistance genes in drug-induced resistant cancer cell lines and post-chemotherapy tissuesCharacterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding.mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer.Connectivity mapping (ssCMap) to predict A20-inducing drugs and their antiinflammatory action in cystic fibrosis.Effects of Averrhoa carambola L. (Oxalidaceae) juice mediated on hyperglycemia, hyperlipidemia, and its influence on regulatory protein expression in the injured kidneys of streptozotocin-induced diabetic mice.Drug similarity search based on combined signatures in gene expression profiles.KRAS mutant colorectal cancer gene signatures identified angiotensin II receptor blockers as potential therapies.Phenotypic screens targeting neurodegenerative diseases.Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products.
P2860
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P2860
Applications of Connectivity Map in drug discovery and development.
description
2012 nî lūn-bûn
@nan
2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Applications of Connectivity Map in drug discovery and development.
@ast
Applications of Connectivity Map in drug discovery and development.
@en
Applications of Connectivity Map in drug discovery and development.
@nl
type
label
Applications of Connectivity Map in drug discovery and development.
@ast
Applications of Connectivity Map in drug discovery and development.
@en
Applications of Connectivity Map in drug discovery and development.
@nl
prefLabel
Applications of Connectivity Map in drug discovery and development.
@ast
Applications of Connectivity Map in drug discovery and development.
@en
Applications of Connectivity Map in drug discovery and development.
@nl
P1433
P1476
Applications of Connectivity Map in drug discovery and development.
@en
P2093
Deepak K Rajpal
Xiaoyan A Qu
P304
P356
10.1016/J.DRUDIS.2012.07.017
P577
2012-08-05T00:00:00Z