Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway
about
MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglionInternational Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligandsThe astrocyte odysseyAtypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor familyRoads Less Traveled: Sexual Dimorphism and Mast Cell Contributions to Migraine PathologyInvolvement of Mammalian RF-Amide Peptides and Their Receptors in the Modulation of Nociception in RodentsOptogenetic and Chemogenetic Approaches for Studying Astrocytes and GliotransmittersIdentification of a G protein-coupled receptor specifically responsive to beta-alanineRNA-Seq Analysis of Human Trigeminal and Dorsal Root Ganglia with a Focus on ChemoreceptorsDevelopment of a homogeneous calcium mobilization assay for high throughput screening of mas-related gene receptor agonists.Development of a FLIPR assay for the simultaneous identification of MrgD agonists and antagonists from a single screen.Sensory neuron-specific receptor activation elicits central and peripheral nociceptive effects in rats.Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice.Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch.Astrocytes in the epileptic brain.Mas-related G-protein-coupled receptors inhibit pathological pain in mice.Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors.Characterization of new G protein-coupled adenine receptors in mouse and hamster.Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1.BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine releaseThe distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia.Atypical signaling and functional desensitization response of MAS receptor to peptide ligands.Sensory neurone-specific receptor-mediated regulation of micturition reflex in urethane-anaesthetized ratsThe itchy scalp--scratching for an explanation.Gastrointestinal pain in functional bowel disorders: sensory neurons as novel drug targets.The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms.Prediction of the 3-D structure of rat MrgA G protein-coupled receptor and identification of its binding siteOrphan GPCRs and neuromodulation.The effect of deletion of the orphan G - protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice.Excitation and modulation of TRPA1, TRPV1, and TRPM8 channel-expressing sensory neurons by the pruritogen chloroquineActivation of spinal MrgC-Gi-NR2B-nNOS signaling pathway by Mas oncogene-related gene C receptor agonist bovine adrenal medulla 8-22 attenuates bone cancer pain in mice.Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways.MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic painG protein-coupled receptor deorphanizations.Molecular signaling and targets from itch: lessons for cough.TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch.Characterization of the Mas-related gene family: structural and functional conservation of human and rhesus MrgX receptors.Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathwaysAdaptive evolution of MRG, a neuron-specific gene family implicated in nociception.Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus.
P2860
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P2860
Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Orphan G protein-coupled recep ...... hrough the Galpha q/11 pathway
@ast
Orphan G protein-coupled recep ...... hrough the Galpha q/11 pathway
@en
Orphan G protein-coupled recep ...... hrough the Galpha q/11 pathway
@nl
type
label
Orphan G protein-coupled recep ...... hrough the Galpha q/11 pathway
@ast
Orphan G protein-coupled recep ...... hrough the Galpha q/11 pathway
@en
Orphan G protein-coupled recep ...... hrough the Galpha q/11 pathway
@nl
prefLabel
Orphan G protein-coupled recep ...... hrough the Galpha q/11 pathway
@ast
Orphan G protein-coupled recep ...... hrough the Galpha q/11 pathway
@en
Orphan G protein-coupled recep ...... hrough the Galpha q/11 pathway
@nl
P2093
P2860
P356
P1476
Orphan G protein-coupled recep ...... hrough the Galpha q/11 pathway
@en
P2093
David J Anderson
Jong-Ik Hwang
Mark J Zylka
Melvin I Simon
Sang-Kyou Han
P2860
P304
14740-14745
P356
10.1073/PNAS.192565799
P407
P50
P577
2002-10-23T00:00:00Z