Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging.
about
A brain detoxifying enzyme for organophosphorus nerve poisons.The origins of femtomolar protein-ligand binding: hydrogen-bond cooperativity and desolvation energetics in the biotin-(strept)avidin binding siteCrystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun † , ‡Crystallization and X-ray structure of full-length recombinant human butyrylcholinesteraseCrystal Structures of Brain Group-VIII Phospholipase A2 in Nonaged Complexes with the Organophosphorus Nerve Agents Soman and Sarin † , ‡Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabunCrystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexesX-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavengerReaction of Cresyl Saligenin Phosphate, the Organophosphorus Agent Implicated in Aerotoxic Syndrome, with Human Cholinesterases: Mechanistic Studies Employing Kinetics, Mass Spectrometry, and X-ray Structure AnalysisCocrystallization studies of full-length recombinant butyrylcholinesterase (BChE) with cocaineStructure and function of an insect -carboxylesterase ( Esterase7) associated with insecticide resistanceUnconventional serine proteases: variations on the catalytic Ser/His/Asp triad configurationButyrylcholinesterase for protection from organophosphorus poisons: catalytic complexities and hysteretic behaviorIn silico modeling of the specific inhibitory potential of thiophene-2,3-dihydro-1,5-benzothiazepine against BChE in the formation of beta-amyloid plaques associated with Alzheimer's disease.Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry.Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents.Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase.Methamidophos, dichlorvos, O-methoate and diazinon pesticides used in Turkey make a covalent bond with butyrylcholinesterase detected by mass spectrometryDetection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvosDichlorvos, chlorpyrifos oxon and Aldicarb adducts of butyrylcholinesterase, detected by mass spectrometry in human plasma following deliberate overdose.Catalytic bioscavengers against toxic esters, an alternative approach for prophylaxis and treatments of poisonings.How similar are enzyme active site geometries derived from quantum mechanical theozymes to crystal structures of enzyme-inhibitor complexes? Implications for enzyme design.Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepineStructural reorganization and preorganization in enzyme active sites: comparisons of experimental and theoretically ideal active site geometries in the multistep serine esterase reaction cycle.Identification of protein adduction using mass spectrometry: Protein adducts as biomarkers and predictors of toxicity mechanisms.Online combination of reversed-phase/reversed-phase and porous graphitic carbon liquid chromatography for multicomponent separation of proteomics and glycoproteomics samples.Why does the G117H mutation considerably improve the activity of human butyrylcholinesterase against sarin? Insights from quantum mechanical/molecular mechanical free energy calculations.Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin.Pseudo-esterase activity of human albumin: slow turnover on tyrosine 411 and stable acetylation of 82 residues including 59 lysines.Hot Spots for Protein Partnerships at the Surface of Cholinesterases and Related α/β Hydrolase Fold Proteins or Domains-A Structural Perspective.Characterization of butyrylcholinesterase in bovine serum.Optimization of Cholinesterase-Based Catalytic Bioscavengers Against Organophosphorus Agents.QM/MM Description of Newly Selected Catalytic Bioscavengers Against Organophosphorus Compounds Revealed Reactivation Stimulus Mediated by Histidine Residue in the Acyl-Binding LoopCarboxylesterases in the Metabolism and Toxicity of Pesticides
P2860
Q24523758-882BBCC7-D5AC-439D-86C8-45AD44A151ECQ24655859-1027BE4A-6072-4352-9A61-4F852C10D75CQ27644348-08EF499A-A0B4-4883-BCB9-E1DBEDC61E41Q27647792-336BF318-84D5-43C8-B6A7-63A0A14AED5BQ27654042-925BF603-1D83-4F44-9973-67D5DB02DEF1Q27654748-EA6B24C7-3ED1-44F4-8FA3-0D9C764A7857Q27655257-2A050EE9-2960-4652-95C3-D906A830A6C1Q27665984-2437AA6A-CE2F-44FC-9EC0-D72B4725C9D9Q27667321-CE140351-5C8C-4F34-90B4-3974FB17A439Q27667574-CF8FDB8D-27CD-4933-A4AC-38B0A47351E0Q27678479-1055E9E7-E5D1-43E1-ABBD-16B4BDB51C90Q28295493-AF55A1CF-0B37-4315-AB1D-6F25013C5A5AQ28393492-05DA788D-58CA-4612-9B1D-F9057428E4B2Q30495524-29B2436F-94E0-44BD-92FA-240B4B7C27A7Q33294201-7B354622-1A4D-4B36-BD83-6DD4F2EA8981Q33337647-57C58F29-8568-4265-BF29-E2174C202A75Q33498052-A98D3337-D3FC-4299-A26D-60A2A2140745Q33540734-821322D8-6E42-444B-8645-94C5DCA8E4C0Q33556324-F16E4AEA-995B-407D-9C47-E18BB2DC7583Q34116714-856B6CDD-A758-443C-ABD2-4497CB99C0FAQ35944247-C5FF00FB-EFA1-418E-A673-130A3AA64260Q36393515-DE442BCA-BDE6-42D0-B963-E40E44B0C2E7Q37029685-1E387054-87BE-4F46-975B-07461557AB2AQ37310018-F0CF6EE8-9005-4546-994D-816543A93B44Q38722096-53236C14-8C20-4583-A69E-AC5C59262402Q39456125-0C84CC04-588F-45A3-BA43-6EF239BFE587Q41130390-DE9D7637-68D0-4BCD-9BE7-41D52FE0AA0EQ41761461-D52062D4-032D-4A81-B766-3B2FFC18B457Q42218432-2F4E62E1-7240-4F25-8A78-BE0AC140738CQ47218668-CE313FDE-6A06-41BA-96AF-1DB8C1D73920Q51140938-463DF80B-E1B6-46F8-BFF9-2A60EA5A21EEQ51758680-94A5D71D-A816-4313-8655-FD3EAD0BED63Q57558945-924C328E-CF61-485D-B2A3-A105683511C4Q58416068-39954313-7BAB-495D-A27A-BEB6D3F99A58
P2860
Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging.
description
2005 nî lūn-bûn
@nan
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Role of water in aging of huma ...... ternative mechanisms of aging.
@ast
Role of water in aging of huma ...... ternative mechanisms of aging.
@en
Role of water in aging of huma ...... ternative mechanisms of aging.
@nl
type
label
Role of water in aging of huma ...... ternative mechanisms of aging.
@ast
Role of water in aging of huma ...... ternative mechanisms of aging.
@en
Role of water in aging of huma ...... ternative mechanisms of aging.
@nl
prefLabel
Role of water in aging of huma ...... ternative mechanisms of aging.
@ast
Role of water in aging of huma ...... ternative mechanisms of aging.
@en
Role of water in aging of huma ...... ternative mechanisms of aging.
@nl
P2093
P356
P1433
P1476
Role of water in aging of huma ...... ternative mechanisms of aging.
@en
P2093
Florian Nachon
Gloria E O Borgstahl
Oksana Lockridge
Oluwatoyin A Asojo
Patrick Masson
P304
P356
10.1021/BI048238D
P407
P577
2005-02-01T00:00:00Z