HTLV-I tax increases genetic instability by inducing DNA double strand breaks during DNA replication and switching repair to NHEJ. - Wikidata - awgldk - TriplyDB

HTLV-I tax increases genetic instability by inducing DNA double strand breaks during DNA replication and switching repair to NHEJ.

HTLV-I tax increases genetic instability by inducing DNA double strand breaks during DNA replication and switching repair to NHEJ.

http://www.wikidata.org/entity/Q34390827

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Activation of the DNA Damage Response by RNA Viruses How does HTLV-1 cause adult T-cell leukaemia/lymphoma (ATL)?Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence The DNA damage response induced by infection with human cytomegalovirus and other viruses Modulation of DNA damage and repair pathways by human tumour viruses Tumor Suppressor Inactivation in the Pathogenesis of Adult T-Cell Leukemia Tax impairs DNA replication forks and increases DNA breaks in specific oncogenic genome regions miR-28-3p is a cellular restriction factor that inhibits human T cell leukemia virus, type 1 (HTLV-1) replication and virus infection.STAT1: A Novel Target of miR-150 and miR-223 Is Involved in the Proliferation of HTLV-I-Transformed and ATL Cells.Inducible nitric oxide synthase mediates DNA double strand breaks in Human T-Cell Leukemia Virus Type 1-induced leukemia/lymphoma.Small PARP inhibitor PJ-34 induces cell cycle arrest and apoptosis of adult T-cell leukemia cells.RAD54 forms DNA repair foci in response to DNA damage in living plant cells.HTLV-I Tax-Mediated Inactivation of Cell Cycle Checkpoints and DNA Repair Pathways Contribute to Cellular Transformation: "A Random Mutagenesis Model"Mutation of epigenetic regulators TET2 and MLL3 in patients with HTLV-I-induced acute adult T-cell leukemia.DNA damage enhances integration of HIV-1 into macrophages by overcoming integrase inhibition.Oncogenic mutations in the FBXW7 gene of adult T-cell leukemia patients WRN-targeted therapy using inhibitors NSC 19630 and NSC 617145 induce apoptosis in HTLV-1-transformed adult T-cell leukemia cells.NOTCH1 Activation Depletes the Pool of Side Population Stem Cells in ATL.HTLV-1 viral oncogene HBZ induces osteolytic bone disease in transgenic mice.PDZ domain-binding motif of Tax sustains T-cell proliferation in HTLV-1-infected humanized mice.The HTLV-1 basic leucine zipper factor (HBZ) attenuates repair of double-stranded DNA breaks via non-homologous end joining (NHEJ).Future Perspectives on Drug Targeting in Adult T Cell Leukemia-Lymphoma.

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P2860

HTLV-I tax increases genetic instability by inducing DNA double strand breaks during DNA replication and switching repair to NHEJ.

http://www.wikidata.org/entity/Q34390827

description

2012 nî lūn-bûn

@nan

2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի օգոստոսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

HTLV-I tax increases genetic i ...... and switching repair to NHEJ.

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HTLV-I tax increases genetic i ...... and switching repair to NHEJ.

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HTLV-I tax increases genetic i ...... and switching repair to NHEJ.

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HTLV-I tax increases genetic i ...... and switching repair to NHEJ.

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HTLV-I tax increases genetic i ...... and switching repair to NHEJ.

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HTLV-I tax increases genetic i ...... and switching repair to NHEJ.

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HTLV-I tax increases genetic i ...... and switching repair to NHEJ.

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HTLV-I tax increases genetic i ...... and switching repair to NHEJ.

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HTLV-I tax increases genetic i ...... and switching repair to NHEJ.

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HTLV-I tax increases genetic i ...... and switching repair to NHEJ.

@en

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Christophe Nicot

http://www.w3.org/2001/XMLSchema#string

Hicham H Baydoun

http://www.w3.org/2001/XMLSchema#string

Shary Shelton

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Xue Tao Bai

http://www.w3.org/2001/XMLSchema#string

P2860

Regulation of DNA double-strand break repair pathway choice

Segregation of NF-kappaB activation through NEMO/IKKgamma by Tax and TNFalpha: implications for stimulus-specific interruption of oncogenic signaling

Pathways of DNA double-strand break repair during the mammalian cell cycle

MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

Disruption of nucleotide excision repair by the human T-cell leukemia virus type 1 Tax protein.

HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule.

HTLV-I Tax-dependent and -independent events associated with immortalization of human primary T lymphocytes.

Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.

Overexpression of p21(waf1) in human T-cell lymphotropic virus type 1-infected cells and its association with cyclin A/cdk2.

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e42226

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scholarly article

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10.1371/JOURNAL.PONE.0042226

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8

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230724250

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22916124

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Human T-lymphotropic virus 1

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3423393

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