COMP mutations, chondrocyte function and cartilage matrix.
about
Multiple epiphyseal dysplasia mutations in MATN3 cause misfolding of the A-domain and prevent secretion of mutant matrilin-3Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation.Mechanisms and models of endoplasmic reticulum stress in chondrodysplasiaThe crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin bindingSkeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagenD469del-COMP retention in chondrocytes stimulates caspase-independent necroptosisA novel COMP mutation in a pseudoachondroplasia family of Chinese origin.RNAi reduces expression and intracellular retention of mutant cartilage oligomeric matrix protein.Cartilage oligomeric matrix protein (COMP) forms part of the connective tissue of normal human hair follicles.Integrative analysis of congenital muscular torticollis: from gene expression to clinical significance.Elevated Levels of Cartilage Oligomeric Matrix Protein during In Vitro Cartilage Matrix Generation Decrease Collagen Fibril Diameter.Canine chondrodysplasia caused by a truncating mutation in collagen-binding integrin alpha subunit 10.Biomechanical spinal growth modulation and progressive adolescent scoliosis--a test of the 'vicious cycle' pathogenetic hypothesis: summary of an electronic focus group debate of the IBSE.Cartilage oligomeric matrix protein promotes cell attachment via two independent mechanisms involving CD47 and alphaVbeta3 integrin.Unique matrix structure in the rough endoplasmic reticulum cisternae of pseudoachondroplasia chondrocytes.Relaxin and beta-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages: progesterone prevents matrix loss.The utility of mouse models to provide information regarding the pathomolecular mechanisms in human genetic skeletal diseases: The emerging role of endoplasmic reticulum stress (Review).Changes in the chondrocyte and extracellular matrix proteome during post-natal mouse cartilage development.A novel form of chondrocyte stress is triggered by a COMP mutation causing pseudoachondroplasia.Collagen XII and XIV, new partners of cartilage oligomeric matrix protein in the skin extracellular matrix suprastructure.Proteomic analysis of Col11a1-associated protein complexes.Static compression of single chondrocytes catabolically modifies single-cell gene expression.Ribozyme-mediated reduction of wild-type and mutant cartilage oligomeric matrix protein (COMP) mRNA and proteinLeucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signalingThe interaction of Thrombospondins with extracellular matrix proteins.Trafficking mechanisms of extracellular matrix macromolecules: insights from vertebrate development and human diseases.Extracellular matrix and developing growth plate.Insider trading: Extracellular matrix proteins and their non-canonical intracellular roles.Novel therapeutic interventions for pseudoachondroplasia.An inducible cartilage oligomeric matrix protein mouse model recapitulates human pseudoachondroplasia phenotypeChop (Ddit3) is essential for D469del-COMP retention and cell death in chondrocytes in an inducible transgenic mouse model of pseudoachondroplasia.Variants within the COMP and THBS2 genes are not associated with Achilles tendinopathy in a case-control study of South African and Australian populations.Autologous chondrocytes as a novel source for neo-chondrogenesis in haemophiliacs.Mutant cartilage oligomeric matrix cartilage (COMP) compromises bone integrity, joint function and the balance between adipogenesis and osteogenesis.Impact of Arginine to Cysteine Mutations in Collagen II on Protein Secretion and Cell Survival.Disruption of extracellular matrix structure may cause pseudoachondroplasia phenotypes in the absence of impaired cartilage oligomeric matrix protein secretion.MED and PSACH COMP mutations affect chondrogenesis in chicken limb bud micromass cultures.Cartilage oligomeric matrix protein: COMPopathies and beyond.
P2860
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P2860
COMP mutations, chondrocyte function and cartilage matrix.
description
2004 nî lūn-bûn
@nan
2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
COMP mutations, chondrocyte function and cartilage matrix.
@ast
COMP mutations, chondrocyte function and cartilage matrix.
@en
COMP mutations, chondrocyte function and cartilage matrix.
@nl
type
label
COMP mutations, chondrocyte function and cartilage matrix.
@ast
COMP mutations, chondrocyte function and cartilage matrix.
@en
COMP mutations, chondrocyte function and cartilage matrix.
@nl
prefLabel
COMP mutations, chondrocyte function and cartilage matrix.
@ast
COMP mutations, chondrocyte function and cartilage matrix.
@en
COMP mutations, chondrocyte function and cartilage matrix.
@nl
P2093
P1433
P1476
COMP mutations, chondrocyte function and cartilage matrix.
@en
P2093
Elizabeth Hayes
Jacqueline T Hecht
Richard Haynes
William G Cole
P304
P356
10.1016/J.MATBIO.2004.09.006
P577
2004-11-18T00:00:00Z