IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation. - Wikidata - awgldk - TriplyDB

IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation.

IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation.

http://www.wikidata.org/entity/Q34396547

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Endotoxin-Induced Tryptophan Degradation along the Kynurenine Pathway: The Role of Indolamine 2,3-Dioxygenase and Aryl Hydrocarbon Receptor-Mediated Immunosuppressive Effects in Endotoxin Tolerance and Cancer and Its Implications for Immunoparalysis IDO2 in Immunomodulation and Autoimmune Disease Trial watch: IDO inhibitors in cancer therapy IDO2: A Pathogenic Mediator of Inflammatory Autoimmunity State-of-the-art of regulatory dendritic cells in cancer Natural Selection in the Great Apes Durable therapeutic efficacy utilizing combinatorial blockade against IDO, CTLA-4, and PD-L1 in mice with brain tumors.Tryptophan-catabolizing enzymes - party of three IDO2 is a critical mediator of autoantibody production and inflammatory pathogenesis in a mouse model of autoimmune arthritis.Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists.Heme-binding-mediated negative regulation of the tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) by IDO2 IDO1 and IDO2 non-synonymous gene variants: correlation with crohn's disease risk and clinical phenotype.Tryptophan-degrading enzymes in tumoral immune resistance.Classification of current anticancer immunotherapies IDO1 Deficiency Does Not Affect Disease in Mouse Models of Systemic Juvenile Idiopathic Arthritis and Secondary Hemophagocytic Lymphohistiocytosis.B Cell-Intrinsic IDO1 Regulates Humoral Immunity to T Cell-Independent Antigens.Interactions between inflammatory mediators and corticosteroids regulate transcription of genes within the Kynurenine Pathway in the mouse hippocampus.IDO2 Modulates T Cell-Dependent Autoimmune Responses through a B Cell-Intrinsic Mechanism.The prognostic potential of alternative transcript isoforms across human tumors.Immunomodulatory Factors Galectin-9 and Interferon-Gamma Synergize to Induce Expression of Rate-Limiting Enzymes of the Kynurenine Pathway in the Mouse Hippocampus.Gene silencing of indoleamine 2,3-dioxygenase 2 in melanoma cells induces apoptosis through the suppression of NAD+ and inhibits in vivo tumor growth.IDO1 is an Integral Mediator of Inflammatory Neovascularization.The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs.The potential of targeting indoleamine 2,3-dioxygenase for cancer treatment.Therapeutic targeting of inflammation and tryptophan metabolism in colon and gastrointestinal cancer.Immunometabolism within the tuberculosis granuloma: amino acids, hypoxia, and cellular respiration.Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy.Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss.Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas.Prevention and treatment of cancers by immune modulating nutrients.Modulation of cancer-specific immune responses by amino acid degrading enzymes.Heme-containing enzymes and inhibitors for tryptophan metabolism.Low efficiency IDO2 enzymes are conserved in lower vertebrates, whereas higher efficiency IDO1 enzymes are dispensable.Efficient tryptophan-catabolizing activity is consistently conserved through evolution of TDO enzymes, but not IDO enzymes.Inhibition of indoleamine 2,3-dioxygenase 1 expression alters immune response in colon tumor microenvironment in mice.Investigation of the Tissue Distribution and Physiological Roles of Indoleamine 2,3-Dioxygenase-2.CIMT 2016: Mechanisms of efficacy in cancer immunotherapy - Report on the 14th Annual Meeting of the Association for Cancer Immunotherapy May 10-12 2016, Mainz, Germany.Discovery of IDO1 Inhibitors: From Bench to Bedside.Glia- and tissue-specific changes in the Kynurenine Pathway after treatment of mice with lipopolysaccharide and dexamethasone.

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P2860

IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation.

http://www.wikidata.org/entity/Q34396547

description

2014 nî lūn-bûn

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2014 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2014 թվականի հունվարին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

IDO2 is critical for IDO1-medi ...... dant function in inflammation.

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IDO2 is critical for IDO1-medi ...... dant function in inflammation.

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IDO2 is critical for IDO1-medi ...... dant function in inflammation.

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type

label

IDO2 is critical for IDO1-medi ...... dant function in inflammation.

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IDO2 is critical for IDO1-medi ...... dant function in inflammation.

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IDO2 is critical for IDO1-medi ...... dant function in inflammation.

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prefLabel

IDO2 is critical for IDO1-medi ...... dant function in inflammation.

@ast

IDO2 is critical for IDO1-medi ...... dant function in inflammation.

@en

IDO2 is critical for IDO1-medi ...... dant function in inflammation.

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International Immunology

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IDO2 is critical for IDO1-medi ...... dant function in inflammation.

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Alexander J Muller

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Andrew L Mellor

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Babak Baban

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Courtney Smith

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Elizabeth Pigott

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George C Prendergast

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James B DuHadaway

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Laura Mandik-Nayak

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Martin P Keough

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Phillip Chandler

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P2860

Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice

Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan

Prevention of allogeneic fetal rejection by tryptophan catabolism

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific

Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune re

Tolerogenic dendritic cells

Overlapping roles for granulocyte-macrophage colony-stimulating factor and interleukin-3 in eosinophil homeostasis and contact hypersensitivity.

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357-367

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scholarly article

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10.1093/INTIMM/DXT073

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7

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26

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Lauren M.F. Merlo

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2014-01-08T00:00:00Z

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259630366

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24402311

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4432394

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