The influence of CYP2D6 polymorphism and quinidine on the disposition and antitussive effect of dextromethorphan in humans.
about
Applications of CYP450 testing in the clinical settingFluoxetine- and norfluoxetine-mediated complex drug-drug interactions: in vitro to in vivo correlation of effects on CYP2D6, CYP2C19, and CYP3A4Comparative effects of dextromethorphan and dextrorphan on nicotine discrimination in rats.Prediction of in vivo drug clearance from in vitro data. I: impact of inter-individual variability.Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity.A randomized placebo controlled trial to evaluate the effects of butamirate and dextromethorphan on capsaicin induced cough in healthy volunteers.Inhibition of cough reflex sensitivity by diphenhydramine during acute viral respiratory tract infection.Physiologically based modelling of inhibition of metabolism and assessment of the relative potency of drug and metabolite: dextromethorphan vs. dextrorphan using quinidine inhibitionClinical inhibition of CYP2D6-catalysed metabolism by the antianginal agent perhexiline.The antitussive effect of dextromethorphan in relation to CYP2D6 activity.Influence of hydroxychloroquine on the bioavailability of oral metoprololAre circulating metabolites important in drug-drug interactions?: Quantitative analysis of risk prediction and inhibitory potency.Review: Effect of drugs on human cough reflex sensitivity to inhaled capsaicin.A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women.Dextromethorphan inhibits activations and functions in dendritic cells.Effect of N-Methyl-D-Aspartate Receptor Antagonist Dextromethorphan on Opioid Analgesia in Pediatric Intensive Care Unit.Dextromethorphan/quinidine: in pseudobulbar affect.Dextromethorphan/quinidine: a review of its use in adults with pseudobulbar affect.Toward standardized reporting of drug interactions: the READI checklist for anecdotal reports.AVP-786 for the treatment of agitation in dementia of the Alzheimer's type.A clinical investigation of inhibitory effect of panobinostat on CYP2D6 substrate in patients with advanced cancer.Pharmacokinetics of dextromethorphan and its metabolites in horses following a single oral administration.Quantitative prediction of cytochrome P450 (CYP) 2D6-mediated drug interactions.Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling.Dextromethorphan Exhibits Anti-inflammatory and Immunomodulatory Effects in a Murine Model of Collagen-Induced Arthritis and in Human Rheumatoid ArthritisPharmacokinetic profile of dextromethorphan hydrobromide in a syrup formulation in children and adolescents.Randomized open-label trial of dextromethorphan in Rett syndrome.Classifying drug interactions.Linezolid: pharmacokinetic and pharmacodynamic evaluation of coadministration with pseudoephedrine HCl, phenylpropanolamine HCl, and dextromethorpan HBr.Effect of terbinafine on the pharmacokinetics and pharmacodynamics of desipramine in healthy volunteers identified as cytochrome P450 2D6 (CYP2D6) extensive metabolizers.Pharmacokinetics of dextromethorphan after single or multiple dosing in combination with quinidine in extensive and poor metabolizers.Prediction of drug-drug interactions using physiologically-based pharmacokinetic models of CYP450 modulators included in Simcyp software.Understanding the relative roles of pharmacogenetics and ontogeny in pediatric drug development and regulatory science.The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2D6 Substrates.Effect of cinacalcet hydrochloride, a new calcimimetic agent, on the pharmacokinetics of dextromethorphan: in vitro and clinical studies.A rapid and simple LC–MS/MS method for the simultaneous evaluation of CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 hydroxylation capacity
P2860
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P2860
The influence of CYP2D6 polymorphism and quinidine on the disposition and antitussive effect of dextromethorphan in humans.
description
1996 nî lūn-bûn
@nan
1996 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
The influence of CYP2D6 polymo ...... of dextromethorphan in humans.
@ast
The influence of CYP2D6 polymo ...... of dextromethorphan in humans.
@en
The influence of CYP2D6 polymo ...... of dextromethorphan in humans.
@nl
type
label
The influence of CYP2D6 polymo ...... of dextromethorphan in humans.
@ast
The influence of CYP2D6 polymo ...... of dextromethorphan in humans.
@en
The influence of CYP2D6 polymo ...... of dextromethorphan in humans.
@nl
prefLabel
The influence of CYP2D6 polymo ...... of dextromethorphan in humans.
@ast
The influence of CYP2D6 polymo ...... of dextromethorphan in humans.
@en
The influence of CYP2D6 polymo ...... of dextromethorphan in humans.
@nl
P2093
P2860
P1476
The influence of CYP2D6 polymo ...... of dextromethorphan in humans
@en
P2093
P2860
P304
P356
10.1016/S0009-9236(96)90056-9
P407
P50
P577
1996-09-01T00:00:00Z