Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission - Wikidata - awgldk - TriplyDB

Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission

Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission

http://www.wikidata.org/entity/Q34405195

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Stem Cell Modeling of Core Binding Factor Acute Myeloid Leukemia When stem cells grow old: phenotypes and mechanisms of stem cell aging Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance Epigenetic regulation of hematopoietic stem cell aging Molecular-defined clonal evolution in patients with chronic myeloid leukemia independent of the BCR-ABL status.Genomic Classification and Prognosis in Acute Myeloid Leukemia.DNMT3A and TET2 in the Pre-Leukemic Phase of Hematopoietic Disorders Concise Review: Induced Pluripotent Stem Cells as New Model Systems in Oncology Advancing the Minimal Residual Disease Concept in Acute Myeloid Leukemia Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence Age-related clonal hematopoiesis associated with adverse outcomes Measurable residual disease testing in acute myeloid leukaemia.Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia.Stem cells are units of natural selection for tissue formation, for germline development, and in cancer development Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis Hematopoietic stem cell origin of BRAFV600E mutations in hairy cell leukemia Epigenetics in normal and malignant hematopoiesis: An overview and update 2017.Efficacy and Biological Correlates of Response in a Phase II Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia.The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle Individualizing Therapeutic Strategies in Acute Myeloid Leukemia: Moving Beyond the 'One-Size-Fits-All' Approach.NrasG12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbfβ-SMMHC via activation of MEK/ERK axis.A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells.DNMT3A in haematological malignancies.Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly.Preclinical efficacy of MEK inhibition in Nras-mutant AML.Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition.Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.miR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia.Controlling pre-leukemic thymocyte self-renewal.The crossroads between cancer stem cells and aging.Quantitative detection of DNMT3A R882H mutation in acute myeloid leukemia Targeted Therapy of FLT3 in Treatment of AML-Current Status and Future Directions.Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity The serum tryptase test: an emerging robust biomarker in clinical hematology.High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia.

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Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission

http://www.wikidata.org/entity/Q34405195

description

2014 nî lūn-bûn

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2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2014 թվականի փետրվարին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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Preleukemic mutations in human ...... ators and persist in remission

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Preleukemic mutations in human ...... ators and persist in remission

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Preleukemic mutations in human ...... ators and persist in remission

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Preleukemic mutations in human ...... ators and persist in remission

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Preleukemic mutations in human ...... ators and persist in remission

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Preleukemic mutations in human ...... ators and persist in remission

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Preleukemic mutations in human ...... ators and persist in remission

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Proceedings of the National Academy of Sciences of the United States of America

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Preleukemic mutations in human ...... ators and persist in remission

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Bruno C Medeiros

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Irving L Weissman

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M Ryan Corces-Zimmerman

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Ravindra Majeti

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Wan-Jen Hong

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P2860

A Quantitative Measurement of the Human Somatic Mutation Rate

Genetic diagnosis by whole exome capture and massively parallel DNA sequencing

Targeted capture and massively parallel sequencing of 12 human exomes

Recurring mutations found by sequencing an acute myeloid leukemia genome

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood

AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

DNMT3A Mutations in Acute Myeloid Leukemia

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes.

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