Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase - Wikidata - awgldk - TriplyDB

Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase

Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase

http://www.wikidata.org/entity/Q34406813

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Three decades of beta-lactamase inhibitors The Acylation Mechanism of CTX-M β-Lactamase at 0.88 Å Resolution Genetic and Structural Characterization of an L201P Global Suppressor Substitution in TEM-1 β-Lactamase An Antibiotic-Resistance Enzyme from a Deep-Sea Bacterium The active site protonation states of perdeuterated Toho-1 β-lactamase determined by neutron diffraction support a role for Glu166 as the general base in acylation Structure of the extended-spectrum β-lactamase TEM-72 inhibited by citrate Crystal Structure of a Preacylation Complex of the β-Lactamase Inhibitor Sulbactam Bound to a Sulfenamide Bond-Containing Thiol-β-lactamase Neutron and X-ray Crystal Structures of a Perdeuterated Enzyme Inhibitor Complex Reveal the Catalytic Proton Network of the Toho-1 -Lactamase for the Acylation Reaction The Importance of thetrans-Enamine Intermediate as a β-Lactamase Inhibition Strategy Probed in Inhibitor-Resistant SHV β-Lactamase Variants Can Inhibitor-Resistant Substitutions in the Mycobacterium tuberculosis -Lactamase BlaC Lead to Clavulanate Resistance?: a Biochemical Rationale for the Use of -Lactam- -Lactamase Inhibitor Combinations β-Lactamase Inhibition by 7-Alkylidenecephalosporin Sulfones: Allylic Transposition and Formation of an Unprecedented Stabilized Acyl-Enzyme Insight into the effect of inhibitor resistant S130G mutant on physico-chemical properties of SHV type beta-lactamase: a molecular dynamics study Saturation mutagenesis of Asn152 reveals a substrate selectivity switch in P99 cephalosporinase The role of a second-shell residue in modifying substrate and inhibitor interactions in the SHV beta-lactamase: a study of ambler position Asn276.Polarizable atomic multipole x-ray refinement: hydration geometry and application to macromolecules Multiple global suppressors of protein stability defects facilitate the evolution of extended-spectrum TEM β-lactamases.Combinatorial active-site variants confer sustained clavulanate resistance in BlaC β-lactamase from Mycobacterium tuberculosis.Variants of β-lactamase KPC-2 that are resistant to inhibition by avibactam.Avibactam and inhibitor-resistant SHV β-lactamases Designing Irreversible Inhibitors--Worth the Effort?Characterization of the global stabilizing substitution A77V and its role in the evolution of CTX-M β-lactamases.The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition.A novel extended-spectrum β-lactamase, SGM-1, from an environmental isolate of Sphingobium sp Active-Site Protonation States in an Acyl-Enzyme Intermediate of a Class A β-Lactamase with a Monobactam Substrate Natural evolution of TEM-1 β-lactamase: experimental reconstruction and clinical relevance.Reappraising the use of β-lactams to treat tuberculosis.N152G, -S, and -T substitutions in CMY-2 β-lactamase increase catalytic efficiency for cefoxitin and inactivation rates for tazobactam.Homology modeling and virtual screening of inhibitors against TEM- and SHV-type-resistant mutants: A multilayer filtering approach.Rational design of a beta-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 A crystal structure of wt SHV-1 complex with a penam sulfone Computer aided screening of potent inhibitor compounds against inhibitor resistant TEM β-lactamase mutants from traditional Chinese medicine.Screening of inhibitors for S130G inhibitor resistant mutants of TEM type beta-lactamase.

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Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase

http://www.wikidata.org/entity/Q34406813

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2005 nî lūn-bûn

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Brian K Shoichet

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Choonkeun Kim

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Dasantila Golemi-Kotra

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Sergei B Vakulenko

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Shahriar Mobashery

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Veena L Thomas

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P2860

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Structure of the SHV-1 beta-lactamase

X-ray structure of the Asn276Asp variant of the Escherichia coli TEM-1 beta-lactamase: direct observation of electrostatic modulation in resistance to inactivation by clavulanic acid

Inhibition of the SHV-1 beta-lactamase by sulfones: crystallographic observation of two reaction intermediates with tazobactam

Noncovalent interaction energies in covalent complexes: TEM-1 beta-lactamase and beta-lactams

An ultrahigh resolution structure of TEM-1 beta-lactamase suggests a role for Glu166 as the general base in acylation

The structural bases of antibiotic resistance in the clinically derived mutant beta-lactamases TEM-30, TEM-32, and TEM-34

Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs

Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 A resolution

Crystal structure of Escherichia coli TEM1 beta-lactamase at 1.8 A resolution

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10.1021/BI0502700

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15981999

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