The loss of a single telomere can result in instability of multiple chromosomes in a human tumor cell line.
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Telomere dysfunction and chromosome instabilityDeletion of the Tetrahymena thermophila rDNA replication fork barrier region disrupts macronuclear rDNA excision and creates a fragile site in the micronuclear genomeComplex chromosomal rearrangements mediated by break-induced replication involve structure-selective endonucleases.Stabilization of dicentric translocations through secondary rearrangements mediated by multiple mechanisms in S. cerevisiae.Fusion of nearby inverted repeats by a replication-based mechanism leads to formation of dicentric and acentric chromosomes that cause genome instability in budding yeast.Effect of telomere proximity on telomere position effect, chromosome healing, and sensitivity to DNA double-strand breaks in a human tumor cell line.Increased genomic alteration complexity and telomere shortening in B-CLL cells resistant to radiation-induced apoptosis.Transmission of Induced Chromosomal Aberrations through Successive Mitotic Divisions in Human Lymphocytes after In Vitro and In Vivo Radiation.Increased sensitivity of subtelomeric regions to DNA double-strand breaks in a human cancer cell lineCrosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis.Telomere loss as a mechanism for chromosome instability in human cancerTelomeres, chromosome instability and cancerThe role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line.Lead Exposure Induces Telomere Instability in Human CellsSubtelomeric regions in mammalian cells are deficient in DNA double-strand break repair.Radiation exposure from imaging tests: is there an increased cancer risk?Cytokinesis breaks dicentric chromosomes preferentially at pericentromeric regions and telomere fusions.Cascades of genetic instability resulting from compromised break-induced replication.PIF1 disruption or NBS1 hypomorphism does not affect chromosome healing or fusion resulting from double-strand breaks near telomeres in murine embryonic stem cells.Maintaining the end: roles of telomere proteins in end-protection, telomere replication and length regulationMaintenance of very long telomeres by recombination in the Kluyveromyces lactis stn1-M1 mutant involves extreme telomeric turnover, telomeric circles, and concerted telomeric amplification.Mechanisms of telomere loss and their consequences for chromosome instability.Chromosome healing by de novo telomere addition in Saccharomyces cerevisiae.Translesion Polymerases Drive Microhomology-Mediated Break-Induced Replication Leading to Complex Chromosomal Rearrangements.The roles of telomerase in the generation of polyploidy during neoplastic cell growth.Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence.Defective break-induced replication leads to half-crossovers in Saccharomyces cerevisiae.Telomere dysfunction and telomerase activation in cancer--a pathological paradox?Telomere loss provokes multiple pathways to apoptosis and produces genomic instability in Drosophila melanogaster.Constitutive short telomere length of chromosome 17p and 12q but not 11q and 2p is associated with an increased risk for esophageal cancer.Alternative lengthening of telomeres: recurrent cytogenetic aberrations and chromosome stability under extreme telomere dysfunction.Alternative lengthening of human telomeres is a conservative DNA replication process with features of break-induced replication.Chromosomal aberrations involving telomeres and interstitial telomeric sequences.Break-induced replication: functions and molecular mechanism.G-quadruplexes as potential therapeutic targets for embryonal tumors.Low- and High-LET Ionizing Radiation Induces Delayed Homologous Recombination that Persists for Two Weeks before Resolving.Telomeres in cancer: tumour suppression and genome instability.Duplicated chromosomal fragments stabilize shortened telomeres in normal human IMR-90 cells before transition to senescence.Transformation of human mesenchymal stem cells in radiation carcinogenesis: long-term effect of ionizing radiation.High Mobility Group A2 protects cancer cells against telomere dysfunction.
P2860
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P2860
The loss of a single telomere can result in instability of multiple chromosomes in a human tumor cell line.
description
2005 nî lūn-bûn
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2005 թուականի Մարտին հրատարակուած գիտական յօդուած
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2005 թվականի մարտին հրատարակված գիտական հոդված
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2005年の論文
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2005年論文
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2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
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2005年论文
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name
The loss of a single telomere ...... es in a human tumor cell line.
@ast
The loss of a single telomere ...... es in a human tumor cell line.
@en
The loss of a single telomere ...... es in a human tumor cell line.
@nl
type
label
The loss of a single telomere ...... es in a human tumor cell line.
@ast
The loss of a single telomere ...... es in a human tumor cell line.
@en
The loss of a single telomere ...... es in a human tumor cell line.
@nl
prefLabel
The loss of a single telomere ...... es in a human tumor cell line.
@ast
The loss of a single telomere ...... es in a human tumor cell line.
@en
The loss of a single telomere ...... es in a human tumor cell line.
@nl
P2093
P1476
The loss of a single telomere ...... es in a human tumor cell line.
@en
P2093
Géraldine Pottier
John P Murnane
Laure Sabatier
Michelle Ricoul
P304
P356
10.1158/1541-7786.MCR-04-0194
P577
2005-03-01T00:00:00Z