L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way - Wikidata - awgldk - TriplyDB

L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way

L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way

http://www.wikidata.org/entity/Q34416102

about

Ribosomopathies: Global process, tissue specific defects Ribosomopathies and the paradox of cellular hypo- to hyperproliferation.L-leucine partially rescues translational and developmental defects associated with zebrafish models of Cornelia de Lange syndrome.Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.The Ribosome Biogenesis Protein Nol9 Is Essential for Definitive Hematopoiesis and Pancreas Morphogenesis in Zebrafish.Biology of the bone marrow microenvironment and myelodysplastic syndromes.RPL27A is a target of miR-595 and may contribute to the myelodysplastic phenotype through ribosomal dysgenesis Probing the mechanisms underlying human diseases in making ribosomes.Understanding the regulation of vertebrate hematopoiesis and blood disorders - big lessons from a small fish.Modeling Myeloid Malignancies Using Zebrafish.How Ribosomes Translate Cancer.

P2860

Q26781112-11BC1B3B-7C3A-4CFE-BC37-43281979EC01 Q34457472-22323410-4C02-43A6-973C-9208F071E6D0 Q35152809-085C2F4B-FA6A-40AA-B0BF-6F5A4B2E35CD Q35189855-D4A852E2-C50B-4FF5-BC79-BCED5EE44A15 Q35478977-C1516A20-E023-4FE3-8C2C-E095F7378DBC Q35856958-1172B361-5FAC-419A-83AD-EEF003D1FDE6 Q36201068-45994AB8-B734-4D9A-B850-97EAA47EDCD5 Q37565308-67BDAD17-F4E8-4C7A-B512-6194AE9B604B Q38928588-C66275C5-E946-4A65-BDAB-9593246605BA Q38951357-64673D54-649B-4DAE-9848-B5EDB37FE0B2 Q47108992-4C3C2BC1-D9A1-4E18-94C4-25929ABF605C Q47782255-BA5E2CE4-E95B-4DB0-A870-327F46403CAB

P2860

L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way

http://www.wikidata.org/entity/Q34416102

description

2014 nî lūn-bûn

@nan

2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

L-Leucine improves the anaemia ...... rome in a TP53-independent way

@ast

L-Leucine improves the anaemia ...... rome in a TP53-independent way

@en

L-Leucine improves the anaemia ...... rome in a TP53-independent way

@nl

type

label

L-Leucine improves the anaemia ...... rome in a TP53-independent way

@ast

L-Leucine improves the anaemia ...... rome in a TP53-independent way

@en

L-Leucine improves the anaemia ...... rome in a TP53-independent way

@nl

prefLabel

L-Leucine improves the anaemia ...... rome in a TP53-independent way

@ast

L-Leucine improves the anaemia ...... rome in a TP53-independent way

@en

L-Leucine improves the anaemia ...... rome in a TP53-independent way

@nl

P1433

Q34416102-F4641269-C33A-42BA-B3F0-5A04F426616C

P1476

Q34416102-F006C1C1-3E8A-4AE0-B29B-A569236D33A5

P2093

Q34416102-2614DFDD-8EF3-4665-B546-F88461C9AECF

Q34416102-42A38AA4-8D8D-4A21-B87B-4C8D9AA91075

Q34416102-601F59E9-F3E8-4779-ACCE-4EAE6BC06992

Q34416102-69CFAF40-7B87-49DC-831D-2B200DED8451

Q34416102-B1C8E0B5-1B9D-4488-940F-3AD9A42C7F59

Q34416102-BDBF98D6-2AE1-46F7-8AE0-792BA984D23A

Q34416102-DBAF0E87-F6DD-43DD-8931-AE0F286638F0

Q34416102-F0127844-1654-40BB-990F-846D38EBAD25

Q34416102-FA49DD2D-1E88-4338-9B93-EB78AD4AE04B

P2860

Q34416102-09D8682F-0B61-47A5-B431-3D0BB6494C16

Q34416102-1098F862-3679-4B01-9276-E1829E1DD842

Q34416102-137DECE4-7D0E-476E-9723-700172E69C94

Q34416102-1F9B021F-38BD-41CB-98C6-926D1A1C432A

Q34416102-2CB4355E-1D55-4CC3-A8B8-B0BC9FC692F9

Q34416102-4161EFD7-C498-4AAF-A378-217EE5E02C19

Q34416102-4B2EAB0F-18E8-477A-895F-1E698B159B0C

Q34416102-5C936DFA-D243-4748-8FBE-CE8BBBCC4A52

Q34416102-9CE8D127-5F33-455C-A1CD-C4E46F95E461

Q34416102-C3CA2263-0EF9-42E4-A20B-EA992A2DE2FB

P304

Q34416102-E8734BB6-F849-494E-B9A6-9F7F9BD78A9B

P31

Q34416102-FD2227A8-74EC-4934-95CD-E3043180A52E

P356

Q34416102-F1229E77-4100-4A9B-A30D-065DE582A0CD

P407

Q34416102-A2198390-83E4-4E96-80F8-54E502CBD4EA

P433

Q34416102-BC1402F7-D429-4176-8EE9-90017C674D19

P478

Q34416102-3CB991BF-41F1-4E7F-95E3-7A6A8D1BCCBF

P577

Q34416102-BEE58B18-8E69-4E55-8402-428FAC79D7A2

P698

Q34416102-B2D53289-5410-4A9B-8706-3040CC96B738

P932

Q34416102-078355C2-5F98-4BA9-B5EF-DDD157CA4076

P356

P1433

British Journal of Haematology

P1476

L-Leucine improves the anaemia ...... rome in a TP53-independent way

@en

P2093

A Thomas Look

http://www.w3.org/2001/XMLSchema#string

Anupama Narla

http://www.w3.org/2001/XMLSchema#string

Arati Khanna-Gupta

http://www.w3.org/2001/XMLSchema#string

Benjamin L Ebert

http://www.w3.org/2001/XMLSchema#string

David M Raiser

http://www.w3.org/2001/XMLSchema#string

Elspeth M Payne

http://www.w3.org/2001/XMLSchema#string

Nancy Berliner

http://www.w3.org/2001/XMLSchema#string

Nirmalee Abayasekara

http://www.w3.org/2001/XMLSchema#string

Slater N Hurst

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

Successful treatment of a Diamond-Blackfan anemia patient with amino acid leucine

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors.

Ribosomopathies: human disorders of ribosome dysfunction.

Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells.

p53-Independent cell cycle and erythroid differentiation defects in murine embryonic stem cells haploinsufficient for Diamond Blackfan anemia-proteins: RPS19 versus RPL5.

Incidence of neoplasia in Diamond Blackfan anemia: a report from the Diamond Blackfan Anemia Registry.

L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway.

Activation of the mTOR pathway by the amino acid (L)-leucine in the 5q- syndrome and other ribosomopathies.

Loss of tumor suppressor RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity.

P304

524-528

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1111/BJH.13069

http://www.w3.org/2001/XMLSchema#string

P407

P433

4

http://www.w3.org/2001/XMLSchema#string

P478

167

http://www.w3.org/2001/XMLSchema#string

P577

2014-08-07T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

25098371

http://www.w3.org/2001/XMLSchema#string

P932

4211992

http://www.w3.org/2001/XMLSchema#string