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Targeting histone lysine demethylases - progress, challenges, and the future

Targeting histone lysine demethylases - progress, challenges, and the future

http://www.wikidata.org/entity/Q34421279

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Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy Catalytic strategies of the non-heme iron dependent oxygenases and their roles in plant biology Epigenetic regulators and their impact on therapy in acute myeloid leukemia Epigenetic regulation by histone demethylases in hypoxia High-throughput screening to identify inhibitors of lysine demethylases Substituted 2-(2-aminopyrimidin-4-yl)pyridine-4-carboxylates as potent inhibitors of JumonjiC domain-containing histone demethylases An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells Alterations of Epigenetic Regulators in Pancreatic Cancer and Their Clinical Implications LSD1 Histone Demethylase Assays and Inhibition Epigenetics in normal and malignant hematopoiesis: An overview and update 2017.Chromatin and oxygen sensing in the context of JmjC histone demethylases Readers, writers, and erasers: chromatin as the whiteboard of heart disease Novel Scaffolds of Cell-Active Histone Demethylase Inhibitors Identified from High-Throughput Screening.Successful strategies in the discovery of small-molecule epigenetic modulators with anticancer potential.Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors.Uropathogenic E. coli (UPEC) Infection Induces Proliferation through Enhancer of Zeste Homologue 2 (EZH2).KDM4A, KDM4B and KDM4C in non-small cell lung cancer.Reduced Histone H3 Acetylation in CD4(+) T Lymphocytes: Potential Mechanism of Latent Autoimmune Diabetes in Adults Histone demethylases in physiology and cancer: a tale of two enzymes, JMJD3 and UTX.Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3.KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer.Endoplasmic reticulum stress, genome damage, and cancer.Histone H3K4 trimethylation: dynamic interplay with pre-mRNA splicing.Medicinal chemistry insights in the discovery of novel LSD1 inhibitors.Targeting epigenetic regulators for cancer therapy: modulation of bromodomain proteins, methyltransferases, demethylases, and microRNAs.Epigenetic regulation of cardiac fibrosis.Inhibitors of Protein Methyltransferases and Demethylases.Exploring the epigenetic drug discovery landscape.Toward development of epigenetic drugs for central nervous system disorders: Modulating neuroplasticity via H3K4 methylation.Epigenetic and genetic changes in soft tissue sarcomas: a review.Hologram quantitative structure-activity relationship and comparative molecular interaction field analysis of aminothiazole and thiazolesulfonamide as reversible LSD1 inhibitors.Co-operative intermolecular kinetics of 2-oxoglutarate dependent dioxygenases may be essential for system-level regulation of plant cell physiology.RNA sequencing reveals resistance of TLR4 ligand-activated microglial cells to inflammation mediated by the selective jumonji H3K27 demethylase inhibitor The promise of epigenomic therapeutics in pancreatic cancer The pharmacological role of histone demethylase JMJD3 inhibitor GSK-J4 on glioma cells.Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.Smad3-mediated recruitment of the methyltransferase SETDB1/ESET controls Snail1 expression and epithelial-mesenchymal transition.Inhibition of LSD1 epigenetically attenuates oral cancer growth and metastasis.Two-State Reactivity of Histone Demethylases Containing Jumonji-C Active Sites: Different Mechanisms for Different Methylation Degrees.Inhibitors of both the N-methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases.

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Targeting histone lysine demethylases - progress, challenges, and the future

http://www.wikidata.org/entity/Q34421279

description

2014 nî lūn-bûn

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2014 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Targeting histone lysine demethylases - progress, challenges, and the future

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Targeting histone lysine demethylases - progress, challenges, and the future

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Targeting histone lysine demethylases - progress, challenges, and the future

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Targeting histone lysine demethylases - progress, challenges, and the future

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Targeting histone lysine demethylases - progress, challenges, and the future

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Targeting histone lysine demethylases - progress, challenges, and the future

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Targeting histone lysine demethylases - progress, challenges, and the future

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J.BBAGRM.2014.05.009

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Biochimica et Biophysica Acta

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Targeting histone lysine demethylases - progress, challenges, and the future

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Cyrille C Thinnes

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Katherine S England

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P2860

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

JMJD6 is a histone arginine demethylase

Histone deimination antagonizes arginine methylation

Structural basis of LSD1-CoREST selectivity in histone H3 recognition

Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing

Regulation of p53 activity through lysine methylation

Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release

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1416-1432

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scholarly article

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10.1016/J.BBAGRM.2014.05.009

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12

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Christopher J. Schofield

Rasheduzzaman Chowdhury

Richard J. Hopkinson

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2014-05-21T00:00:00Z

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2014-12-01T00:00:00Z

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262491439

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24859458

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