Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1.
about
Understanding the determinants of selectivity in drug metabolism through modeling of dextromethorphan oxidation by cytochrome P450.Extrapolating in vitro data on drug metabolism to in vivo pharmacokinetics: evaluation of the pharmacokinetic interaction between amitriptyline and fluoxetine.Inhibition of human cytochrome P450 isoforms by nonnucleoside reverse transcriptase inhibitors.Summary of information on human CYP enzymes: human P450 metabolism data.Ontogeny of dextromethorphan O- and N-demethylation in the first year of life.Simultaneous quantitative analysis of dextromethorphan, dextrorphan and chlorphenamine in human plasma by liquid chromatography-electrospray tandem mass spectrometry.Physiologically based modelling of inhibition of metabolism and assessment of the relative potency of drug and metabolite: dextromethorphan vs. dextrorphan using quinidine inhibitionThe antitussive effect of dextromethorphan in relation to CYP2D6 activity.Reductive metabolism of oxymatrine is catalyzed by microsomal CYP3A4.Monoester-Diterpene Aconitum Alkaloid Metabolism in Human Liver Microsomes: Predominant Role of CYP3A4 and CYP3A5.Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity.Quantum mechanical modeling: a tool for the understanding of enzyme reactions.Pharmacokinetic profile of dextromethorphan hydrobromide in a syrup formulation in children and adolescents.Lack of gender differences and large intrasubject variability in cytochrome P450 activity measured by phenotyping with dextromethorphan.mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates.Role of individual human cytochrome P450 enzymes in the in vitro metabolism of hydromorphone.Understanding the relative roles of pharmacogenetics and ontogeny in pediatric drug development and regulatory science.The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2D6 Substrates.
P2860
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P2860
Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1.
description
1997 nî lūn-bûn
@nan
1997 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Metabolism of dextromethorphan ...... , with a possible role of 2E1.
@ast
Metabolism of dextromethorphan ...... , with a possible role of 2E1.
@en
Metabolism of dextromethorphan ...... , with a possible role of 2E1.
@nl
type
label
Metabolism of dextromethorphan ...... , with a possible role of 2E1.
@ast
Metabolism of dextromethorphan ...... , with a possible role of 2E1.
@en
Metabolism of dextromethorphan ...... , with a possible role of 2E1.
@nl
prefLabel
Metabolism of dextromethorphan ...... , with a possible role of 2E1.
@ast
Metabolism of dextromethorphan ...... , with a possible role of 2E1.
@en
Metabolism of dextromethorphan ...... , with a possible role of 2E1.
@nl
P2093
P1476
Metabolism of dextromethorphan ...... , with a possible role of 2E1.
@en
P2093
D J Greenblatt
J Schmider
L L von Moltke
R I Shader
S M Fogelman
P304
P356
10.1002/(SICI)1099-081X(199704)18:3<227::AID-BDD18>3.0.CO;2-L
P577
1997-04-01T00:00:00Z