The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation. - Wikidata - awgldk - TriplyDB

The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation.

The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation.

http://www.wikidata.org/entity/Q34426626

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Hallmarks of cancer and AU-rich elements Feedback Regulation of Kinase Signaling Pathways by AREs and GREs Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs Alternative polyadenylation in the nervous system: to what lengths will 3' UTR extensions take us?The control of inflammation via the phosphorylation and dephosphorylation of tristetraprolin: a tale of two phosphatases mTOR and MAPK: from localized translation control to epilepsy Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFα production A novel high throughput biochemical assay to evaluate the HuR protein-RNA complex formation Deletion of AU-rich elements within the Bcl2 3'UTR reduces protein expression and B cell survival in vivo Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression.Posttranscriptional Regulation Controls Calretinin Expression in Malignant Pleural Mesothelioma.Global target mRNA specification and regulation by the RNA-binding protein ZFP36.Translational regulation of specific mRNAs controls feedback inhibition and survival during macrophage activation TNF and MAP kinase signalling pathways.Interleukin-1/toll-like receptor-induced nuclear factor kappa B signaling participates in intima hyperplasia after carotid artery balloon injury in goto-kakizaki rats: a potential target therapy pathway.Mitogen-activated protein kinase-activated protein kinase 2 deficiency reduces insulin sensitivity in high-fat diet-fed mice.Virulent Francisella tularensis destabilize host mRNA to rapidly suppress inflammation.Tristetraprolin mediates radiation-induced TNF-α production in lung macrophages.Phosphorylation of mitogen- and stress-activated protein kinase-1 in astrocytic inflammation: a possible role in inhibiting production of inflammatory cytokines.p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuli MAPK-activated protein kinase 2-deficiency causes hyperacute tumor necrosis factor-induced inflammatory shock.Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay.A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin.Tristetraprolin Limits Inflammatory Cytokine Production in Tumor-Associated Macrophages in an mRNA Decay-Independent Manner.Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress.Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infection The MK2/HuR signaling pathway regulates TNF-α-induced ICAM-1 expression by promoting the stabilization of ICAM-1 mRNA Model-Based Characterization of Inflammatory Gene Expression Patterns of Activated Macrophages.Tristetraprolin Recruits Eukaryotic Initiation Factor 4E2 To Repress Translation of AU-Rich Element-Containing mRNAs.Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function.LPS-induced production of TNF-α and IL-6 in mast cells is dependent on p38 but independent of TTP Pivotal Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Inflammatory Pulmonary Diseases.Tristetraprolin (TTP): interactions with mRNA and proteins, and current thoughts on mechanisms of action.Post-transcriptional regulation of iron homeostasis in Saccharomyces cerevisiae.The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses.FANCA and FANCC modulate TLR and p38 MAPK-dependent expression of IL-1β in macrophages.MiR-30c protects diabetic nephropathy by suppressing epithelial-to-mesenchymal transition in db/db mice.

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The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation.

http://www.wikidata.org/entity/Q34426626

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2012 nî lūn-bûn

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2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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JOURNAL.PGEN.1002977

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The p38/MK2-driven exchange be ...... element-dependent translation.

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Helmut Holtmann

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Kathrin Laass

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Mohammad Tehrani

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Sonam Dhamija

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P2860

miR-346 controls release of TNF-α protein and stability of its mRNA in rheumatoid arthritis via tristetraprolin stabilization

Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2

Phosphorylation of HuR by Chk2 regulates SIRT1 expression

MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin

Tristetraprolin (TTP)-14-3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-alpha mRNA

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10.1371/JOURNAL.PGEN.1002977

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9

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8

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Matthias Gaestel

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Christopher Tiedje

Natalia Ronkina

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2012-09-27T00:00:00Z

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231742986

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23028373

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3459988

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