The para substituent of S-3-(phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamides is a major structural determinant of in vivo disposition and activity of selective androgen receptor modulators.
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Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraceptionSelective androgen receptor modulators in preclinical and clinical developmentDiscovery and therapeutic promise of selective androgen receptor modulatorsPharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligandsStudy Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials)Crystal Structure of the T877A Human Androgen Receptor Ligand-binding Domain Complexed to Cyproterone Acetate Provides Insight for Ligand-induced Conformational Changes and Structure-based Drug DesignEffect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulatorsSelective androgen receptor modulators as function promoting therapies.The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial.Nonsteroidal selective androgen receptor modulators enhance female sexual motivation.Deciphering the selective androgen receptor modulators paradigm.Enobosarm (GTx-024, S-22): a potential treatment for cachexia.Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140.In vitro and in vivo structure-activity relationships of novel androgen receptor ligands with multiple substituents in the B-ringStructural and Functional Evidence for Testosterone Activation of GPRC6A in Peripheral TissuesArylisothiocyanato selective androgen receptor modulators (SARMs) for prostate cancer.Protective actions of sex steroid hormones in Alzheimer's disease.Mass spectrometric characterization of urinary metabolites of the selective androgen receptor modulator S-22 to identify potential targets for routine doping controls.Effect of para halogen modification of S-3-(phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamides on metabolism and clearance.Lead evaluation of tetrahydroquinolines as nonsteroidal selective androgen receptor modulators for the treatment of osteoporosis.Antioxidant activity of diphenylpropionamide derivatives: synthesis, biological evaluation and computational analysis.Tissue Selective Androgen Receptor Modulators (SARMs) Increase Pelvic Floor Muscle Mass in Ovariectomized Mice.Dioxin Exposure in the Manufacture of Pesticide Production as a Risk Factor for Death from Prostate Cancer: A Meta-analysis.Analytical strategies to detect enobosarm administration in bovines.Absorption, distribution, metabolism and excretion of the novel SARM GTx-024 [(S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide] in rats.
P2860
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P2860
The para substituent of S-3-(phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamides is a major structural determinant of in vivo disposition and activity of selective androgen receptor modulators.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The para substituent of S-3-
@nl
The para substituent of S-3-(p ...... androgen receptor modulators.
@ast
The para substituent of S-3-(p ...... androgen receptor modulators.
@en
type
label
The para substituent of S-3-
@nl
The para substituent of S-3-(p ...... androgen receptor modulators.
@ast
The para substituent of S-3-(p ...... androgen receptor modulators.
@en
prefLabel
The para substituent of S-3-
@nl
The para substituent of S-3-(p ...... androgen receptor modulators.
@ast
The para substituent of S-3-(p ...... androgen receptor modulators.
@en
P2093
P356
P1476
The para substituent of S-3-(p ...... androgen receptor modulators.
@en
P2093
Dong Jin Hwang
Duane D Miller
James T Dalton
Juhyun Kim
P304
P356
10.1124/JPET.105.088344
P407
P577
2005-06-29T00:00:00Z