A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations
about
In vivo continuous directed evolutionA Panel of Protease-Responsive RNA Polymerases Respond to Biochemical Signals by Production of Defined RNA Outputs in Live CellsIdentification and Characterization of a New 7-Aminocephalosporanic Acid Deacetylase from Thermophilic Bacterium Alicyclobacillus tengchongensis.Continuous directed evolution of DNA-binding proteins to improve TALEN specificity.In vivo continuous evolution of genes and pathways in yeastDevelopment of potent in vivo mutagenesis plasmids with broad mutational spectra.Harnessing natural product assembly lines: structure, promiscuity, and engineering.Continuous evolution of Bacillus thuringiensis toxins overcomes insect resistance.Methods for the directed evolution of proteins.Asunaprevir (BMS-650032) for the treatment of hepatitis C virus.Emerging technologies for protease engineering: New tools to clear out disease.Engineering orthogonal dual transcription factors for multi-input synthetic promoters.Intracellular directed evolution of proteins from combinatorial libraries based on conditional phage replication.Simultaneous selection and counter-selection for the directed evolution of proteases in E. coli using a cytoplasmic anchoring strategy.Phage-assisted continuous evolution of proteases with altered substrate specificity.Engineering 'cell robots' for parallel and highly sensitive screening of biomolecules under in vivo conditions.Continuous directed evolution of aminoacyl-tRNA synthetases.Directing evolution: the next revolution in drug discovery?Crystal structures reveal an elusive functional domain of pyrrolysyl-tRNA synthetase.Evolution of a split RNA polymerase as a versatile biosensor platform.Continuous directed evolution of proteins with improved soluble expression
P2860
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P2860
A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations
description
2014 nî lūn-bûn
@nan
2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
A system for the continuous di ...... eals drug-resistance mutations
@ast
A system for the continuous di ...... eals drug-resistance mutations
@en
A system for the continuous di ...... eals drug-resistance mutations
@nl
type
label
A system for the continuous di ...... eals drug-resistance mutations
@ast
A system for the continuous di ...... eals drug-resistance mutations
@en
A system for the continuous di ...... eals drug-resistance mutations
@nl
prefLabel
A system for the continuous di ...... eals drug-resistance mutations
@ast
A system for the continuous di ...... eals drug-resistance mutations
@en
A system for the continuous di ...... eals drug-resistance mutations
@nl
P2093
P2860
P356
P1476
A system for the continuous di ...... eals drug-resistance mutations
@en
P2093
Ahmed H Badran
Bryan C Dickinson
David R Liu
Michael S Packer
P2860
P2888
P356
10.1038/NCOMMS6352
P407
P577
2014-10-30T00:00:00Z
P5875
P6179
1018009622