p27(kip1) functional regulation in human cancer: a potential target for therapeutic designs.
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Role of T198 modification in the regulation of p27(Kip1) protein stability and functionThe tumor suppressor functions of p27(kip1) include control of the mesenchymal/amoeboid transition.p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling.miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1.Contact inhibition modulates intracellular levels of miR-223 in a p27kip1-dependent mannerCo-depletion of cathepsin B and uPAR induces G0/G1 arrest in glioma via FOXO3a mediated p27 upregulation.Loss of p27kip1 increases genomic instability and induces radio-resistance in luminal breast cancer cells.Cytoplasmic sequestration of p27 via AKT phosphorylation in renal cell carcinoma.CDKN1B, encoding the cyclin-dependent kinase inhibitor 1B (p27), is located in the minimally deleted region of 12p abnormalities in myeloid malignancies and its low expression is a favorable prognostic marker in acute myeloid leukemia.Artemis interacts with the Cul4A-DDB1DDB2 ubiquitin E3 ligase and regulates degradation of the CDK inhibitor p27XMRV accelerates cellular proliferation, transformational activity, and invasiveness of prostate cancer cells by downregulating p27(Kip1).PCAF regulates the stability of the transcriptional regulator and cyclin-dependent kinase inhibitor p27 Kip1.Genetic characterization of p27(kip1) and stathmin in controlling cell proliferation in vivo.p27kip1 controls H-Ras/MAPK activation and cell cycle entry via modulation of MT stability.1,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice.In vitro expression levels of cell-cycle checkpoint proteins are associated with cellular DNA repair capacity in peripheral blood lymphocytes: a multivariate analysisThrombin induces tumor cell cycle activation and spontaneous growth by down-regulation of p27Kip1, in association with the up-regulation of Skp2 and MiR-222Discovery of genes from feces correlated with colorectal cancer progressionp27kip1: An all-round tumor suppressor.p27kip1 expression limits H-Ras-driven transformation and tumorigenesis by both canonical and non-canonical mechanisms.Cyclin-dependent kinase inhibitor p27 as a prognostic biomarker and potential cancer therapeutic target.Gene expression signature of c-MYC-immortalized human fibroblasts reveals loss of growth inhibitory response to TGFβ.Omacetaxine mepesuccinate induces apoptosis and cell cycle arrest, promotes cell differentiation, and reduces telomerase activity in diffuse large B‑cell lymphoma cells.Spy1 participates in the proliferation and apoptosis of epithelial ovarian cancer.SUMOylation regulates p27Kip1 stability and localization in response to TGFβ.MicroRNA miR-24 promotes cell proliferation by targeting the CDKs inhibitors p27Kip1 and p16INK4a.Antitumor effects of novel compound, guttiferone K, on colon cancer by p21Waf1/Cip1-mediated G(0) /G(1) cell cycle arrest and apoptosis.Macrophage migration inhibitory factor regulates proliferation of gastric cancer cells via the PI3K/Akt pathway.Ex vivo magnetofection with magnetic nanoparticles: a novel platform for nonviral tissue engineering.New light on p27(kip1) in breast cancer.Transcriptional and Posttranscriptional Upregulation of p27 Mediates Growth Inhibition of Isorhapontigenin (ISO) on Human Bladder Cancer Cells.Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration.Alteration of G1/S transition regulators influences recurrences in head and neck squamous carcinomas.Cyclin-dependent kinase inhibitors, p16 and p27, demonstrate different expression patterns in thymoma and thymic carcinoma.Landscape of CDKN1B Mutations in Luminal Breast Cancer and Other Hormone-Driven Human Tumors
P2860
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P2860
p27(kip1) functional regulation in human cancer: a potential target for therapeutic designs.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
p27(kip1) functional regulatio ...... arget for therapeutic designs.
@ast
p27(kip1) functional regulatio ...... arget for therapeutic designs.
@en
type
label
p27(kip1) functional regulatio ...... arget for therapeutic designs.
@ast
p27(kip1) functional regulatio ...... arget for therapeutic designs.
@en
prefLabel
p27(kip1) functional regulatio ...... arget for therapeutic designs.
@ast
p27(kip1) functional regulatio ...... arget for therapeutic designs.
@en
P2093
P50
P356
P1476
p27(kip1) functional regulatio ...... target for therapeutic designs
@en
P2093
P304
P356
10.2174/0929867054367149
P577
2005-01-01T00:00:00Z