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Process of Fragment-Based Lead Discovery-A Perspective from NMRPrecision or Personalized Medicine for Cancer Chemotherapy: Is there a Role for Herbal MedicinePharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid DehydrogenasesNatural Products as Tools for Defining How Cellular Metabolism Influences Cellular Immune and Inflammatory Function during Chronic InfectionFluorescence anisotropy (polarization): from drug screening to precision medicine.Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule ProbesChemical databases and virtual screeningA brief review of recent Charcot-Marie-Tooth research and prioritiesA High-Throughput Small Molecule Screen for C. elegans Linker Cell Death InhibitorsVirtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial AgentsA practical Java tool for small-molecule compound appraisalPromiscuous Effects of Some Phenolic Natural Products on Inflammation at Least in Part Arise from Their Ability to Modulate the Expression of Global Regulators, Namely microRNAsModeling the complex pathology of Alzheimer's disease in DrosophilaQuality control of chemical librariesProtein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylationMolecular Mimics of Classic P-Glycoprotein Inhibitors as Multidrug Resistance Suppressors and Their Synergistic Effect on PaclitaxelBiochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug targetAnthelmintic activity in vivo of epiisopiloturine against juvenile and adult worms of Schistosoma mansoniCinnamic Acid Bornyl Ester Derivatives from Valeriana wallichii Exhibit Antileishmanial In Vivo Activity in Leishmania major-Infected BALB/c MiceDetermining the Degree of Promiscuity of Extensively Assayed CompoundsStructure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugsApplications of chemogenomic library screening in drug discoveryNovel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screenSignal transducer and activator of transcription 3 (STAT3) inhibitor, S3I-201, acts as a potent and non-selective alkylating agentAdvances in Bacterial Methionine Aminopeptidase InhibitionCovalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition ReactionsA Workflow to Investigate Exposure and Pharmacokinetic Influences on High-Throughput in Vitro Chemical Screening Based on Adverse Outcome PathwaysPrivileged Structures Revisited.Targeting Non-Catalytic Cysteine Residues Through Structure-Guided Drug DiscoveryIn situ imaging and proteome profiling indicate andrographolide is a highly promiscuous compound.The Essential Medicinal Chemistry of CurcuminData-driven approaches used for compound library design, hit triage and bioactivity modeling in high-throughput screening.New p32/gC1qR Ligands for Targeted Tumor Drug Delivery.Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology.PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS.Small molecules with antiviral activity against the Ebola virusThe promise and peril of chemical probes.Structural dynamics and inhibitor searching for Wnt-4 protein using comparative computational studies.Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme
P2860
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P2860
description
2014 nî lūn-bûn
@nan
2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Chemistry: Chemical con artists foil drug discovery.
@ast
Chemistry: Chemical con artists foil drug discovery.
@en
Chemistry: Chemical con artists foil drug discovery.
@nl
type
label
Chemistry: Chemical con artists foil drug discovery.
@ast
Chemistry: Chemical con artists foil drug discovery.
@en
Chemistry: Chemical con artists foil drug discovery.
@nl
prefLabel
Chemistry: Chemical con artists foil drug discovery.
@ast
Chemistry: Chemical con artists foil drug discovery.
@en
Chemistry: Chemical con artists foil drug discovery.
@nl
P356
P1433
P1476
Chemistry: Chemical con artists foil drug discovery.
@en
P2093
Jonathan Baell
Michael A Walters
P2888
P304
P356
10.1038/513481A
P407
P577
2014-09-01T00:00:00Z
P5875
P6179
1026294014