Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia - Wikidata - awgldk - TriplyDB

Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia

Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia

http://www.wikidata.org/entity/Q34446281

about

MYC, Metabolism, and Cancer Super-enhancers: Asset management in immune cell genomes The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia EBNA2 Drives Formation of New Chromosome Binding Sites and Target Genes for B-Cell Master Regulatory Transcription Factors RBP-jκ and EBF1 Controlling the Master: Chromatin Dynamics at the MYC Promoter Integrate Developmental Signaling Systematic mapping of functional enhancer-promoter connections with CRISPR interference.Human disease modeling reveals integrated transcriptional and epigenetic mechanisms of NOTCH1 haploinsufficiency.The role of Notch receptors in transcriptional regulation Signal transducer and activator of transcription STAT5 is recruited to c-Myc super-enhancer.High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma.Amplification of the bromodomain-containing protein 4 gene in ovarian high-grade serous carcinoma is associated with worse prognosis and survival DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activation.Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia.Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the γ-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case.Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs.Notch1 controls development of the extravillous trophoblast lineage in the human placenta.Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands.Inhibition of bromodomain and extra-terminal proteins (BET) as a potential therapeutic approach in haematological malignancies: emerging preclinical and clinical evidence.Drugging Chromatin in Cancer: Recent Advances and Novel Approaches.β-Catenin is required for T-cell leukemia initiation and MYC transcription downstream of Notch1.Genome-wide identification and characterization of Notch transcription complex-binding sequence-paired sites in leukemia cells.Oncogenic Notch signaling in T-cell and B-cell lymphoproliferative disorders.ChIP-seq in studying epigenetic mechanisms of disease and promoting precision medicine: progresses and future directions.Enhancers and their dynamics during hematopoietic differentiation and emerging strategies for therapeutic action.Transcriptional Addiction in Cancer.The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force.The Varied Roles of Notch in Cancer.Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia.The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia.A long-range cis-regulatory element for class I odorant receptor genes.γ-Secretase inhibitor-resistant glioblastoma stem cells require RBPJ to propagate High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia.The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia.RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia.Notch Signaling in Development, Tissue Homeostasis, and Disease.MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia.A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas.Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies.

P2860

Q26783555-D11CDC55-FA98-4C9B-BB25-CE5AFCA19598 Q26861020-7A7ABF92-3473-464F-BE61-45F8E657C59B Q28075211-88289C5F-4646-4649-9806-8281113A8B0C Q28115221-CF3CBE34-CCF9-472F-B23E-01BAC55881F5 Q28552335-375722A7-9B10-4AC3-AD17-BB8CC24125A8 Q33608508-D8D1552B-6A20-44E2-B880-1872824166A3 Q33709312-406A51E4-F6DB-4FA8-AA6B-64D0C8764B70 Q35177762-B5CFA244-0114-437B-BE32-A6B61DBC217D Q35640825-CC0B45A4-5D3E-4863-8F0A-7A12889C31B3 Q35988744-B681C461-E124-4A12-AA15-D11BB8B3D6B9 Q36178314-69482945-A65D-46F1-BAFB-A32A452456B3 Q36213758-DA8E1A9E-91F4-410E-A22C-E2C3AE691724 Q36341198-F7F882D5-7B28-4B88-B41E-A64754E0E509 Q36355992-AE725ADE-F5F1-457E-BC5D-EE14F86C8865 Q36837426-AB1BE204-E3DC-4307-9D7A-7262D933BA4E Q36851425-52EB2D45-9A3E-465B-A291-36F1CAA42B19 Q36956610-E36ECB95-499E-4E8C-B23F-1C11DED86A0B Q37473736-4B047039-F6CB-4AD4-AC2C-31328FAC1833 Q37730667-BA12201C-0FC4-4875-AC7A-27415C0FD670 Q38542092-7530F088-5385-4CE3-B987-046F8E2F3D58 Q38641649-3E4EAA95-CB04-46BD-B807-A7456A023532 Q38774751-AC387F6A-55F8-4117-969F-77FB2DA99388 Q38808041-31267B0A-717F-48BE-B33B-70B5E0CE0FE9 Q38823047-B1F95CB0-5A1C-4077-8F8F-2B98BD333CEC Q38851252-43F2F1AD-1B4B-466F-8376-FF44778E7705 Q38958989-39D9E591-3C0D-4F36-ACAB-DCF31510BE60 Q39130428-9BD128D7-5CBE-4285-9EA4-DF20A62D214A Q39293613-7A38EE67-ED5E-4EFD-8707-4B6E8F977B3F Q40411894-B7253058-09D1-4202-8014-B6AEDDB9C2B9 Q41660964-572E706C-37D1-4372-8F34-7247D0413614 Q42375711-AE647FD8-973E-4AD8-A924-4A6472362A28 Q42376053-082D1A72-A92C-4835-86B9-C7A6DE0635A9 Q42532937-4055D009-BC7F-46E6-A883-437DAA10E878 Q42733616-E908760C-1D4C-40F6-9F3E-0617E1DC530C Q45062542-113DBCE2-CF10-42F0-B841-0863886BF7C7 Q45065002-0CF7DD4E-0907-483D-A587-606E67EE58F9 Q46795621-529F53E5-8E4D-4193-A047-162208D428E5 Q47402163-60D52516-3482-4825-80B1-994F3E918FA7 Q47767275-F5C81C44-5E93-4135-A98F-26852F0A9953 Q47771125-8E0253FB-A3EC-4186-ACB6-0DDB3304C532

P2860

Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia

http://www.wikidata.org/entity/Q34446281

description

2014 nî lūn-bûn

@nan

2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Long-range enhancer activity d ...... inhibitors in T cell leukemia

@ast

Long-range enhancer activity d ...... inhibitors in T cell leukemia

@en

Long-range enhancer activity d ...... inhibitors in T cell leukemia

@nl

type

label

Long-range enhancer activity d ...... inhibitors in T cell leukemia

@ast

Long-range enhancer activity d ...... inhibitors in T cell leukemia

@en

Long-range enhancer activity d ...... inhibitors in T cell leukemia

@nl

prefLabel

Long-range enhancer activity d ...... inhibitors in T cell leukemia

@ast

Long-range enhancer activity d ...... inhibitors in T cell leukemia

@en

Long-range enhancer activity d ...... inhibitors in T cell leukemia

@nl

P1433

Q34446281-24215BEC-26E0-4E1C-AD21-0C7B479C65C2

P1476

Q34446281-96E29B87-5D17-4472-974D-65F07BA0B7B2

P2093

Q34446281-00749EF3-1AA2-4D76-903B-7010E963ABA9

Q34446281-0148F6D1-A6D9-4DD3-8794-6F84EF93D4DC

Q34446281-0AB04023-F569-421F-9656-25D020905819

Q34446281-25E1E580-87E7-43FF-883B-4BC9F017EAD3

Q34446281-2D94C1A5-CDE6-4E4C-AF80-68C4EC78F243

Q34446281-3206A49F-0057-4A8F-A021-8CE8EBAFC978

Q34446281-479EF74A-407D-4F75-8D05-DF053B7EAB78

Q34446281-755A5D82-E66F-47EC-A729-559C2BFC294E

Q34446281-7C730B85-E136-4BCE-8AA1-AF2E96BE391D

Q34446281-9B5751C2-C0C8-474B-A0B5-ABB786C8C476

P2860

Q34446281-024EED18-8AB0-4EAD-9C7B-8E2A86FA8CF6

Q34446281-074E69E2-720B-4941-8D2F-7E21DC8F91D3

Q34446281-0890779A-1C09-4FBF-ACCB-1C9CC32079CB

Q34446281-09194D36-F4C2-4081-8786-38A418686B25

Q34446281-0D628E65-6FEA-4BCF-8F53-26D099F352F4

Q34446281-0FDEB0C2-8852-416F-94B8-D17CDE72482F

Q34446281-17224182-C81C-4F5A-82A8-B4EFE411081C

Q34446281-18213C18-2E1A-4E53-9B41-E0A43760CBA7

Q34446281-1D75421C-2A22-496D-A316-CEB7E4AC4B21

Q34446281-2171EA7F-25FD-4608-B4B9-CE3FA4CBC232

P304

Q34446281-42512678-76FC-4246-9810-ADEFB93E1A94

P31

Q34446281-49C4B8E9-BDEA-4B03-8AC5-0A11534BC1DF

P356

Q34446281-ECF6D8C3-1AC6-446A-8308-C5EA486F38DF

P407

Q34446281-4B4DBF1A-73A8-4F2D-B2AE-4F36BE5C8DA4

P433

Q34446281-67EB0EB3-C5CE-4DFC-961F-A6C420F0A821

P478

Q34446281-BA009C2C-8D68-44C9-B224-3DB9BBF44E2C

P50

Q34446281-1BD58FC7-37B7-4FCE-B7CC-30D5D51DFA45

Q34446281-828BAD25-2B00-4510-8E10-30BEA8244684

Q34446281-9B0701F7-5599-497A-9BCB-5AD0549C7FA5

P577

Q34446281-288BCDF2-C92C-4E42-8548-C1E2003C1C93

P5875

Q34446281-C3877095-C6AC-445A-A51A-D04E2B900EC0

P698

Q34446281-A6CCAB8A-65CF-4866-88B8-AB84387A722D

P921

Q34446281-E111814B-5139-4F99-8A1F-D6E676C67104

P932

Q34446281-2E24770E-D9D1-4D50-8316-0DEECD97A957

P356

PNAS.1407079111

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Long-range enhancer activity d ...... inhibitors in T cell leukemia

@en

P2093

Birgit Knoechel

http://www.w3.org/2001/XMLSchema#string

Bradley E Bernstein

http://www.w3.org/2001/XMLSchema#string

Claudia Lanauze

http://www.w3.org/2001/XMLSchema#string

Gerd A Blobel

http://www.w3.org/2001/XMLSchema#string

Hongfang Wang

http://www.w3.org/2001/XMLSchema#string

Jon C Aster

http://www.w3.org/2001/XMLSchema#string

Jonathan Schug

http://www.w3.org/2001/XMLSchema#string

Kelly L Arnett

http://www.w3.org/2001/XMLSchema#string

Lumena Louis

http://www.w3.org/2001/XMLSchema#string

Stephen A Liebhaber

http://www.w3.org/2001/XMLSchema#string

P2860

Model-based analysis of ChIP-Seq (MACS)

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex

Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes

Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma.

Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation

Selective inhibition of tumor oncogenes by disruption of super-enhancers

Master transcription factors and mediator establish super-enhancers at key cell identity genes

NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.

P304

E4946-53

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.1407079111

http://www.w3.org/2001/XMLSchema#string

P407

P433

46

http://www.w3.org/2001/XMLSchema#string

P478

111

http://www.w3.org/2001/XMLSchema#string

P50

Xiaole Shirley Liu

Katherine S Forsyth

P577

2014-11-04T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

268742984

http://www.w3.org/2001/XMLSchema#string

P698

25369933

http://www.w3.org/2001/XMLSchema#string

P921

P932

4246292

http://www.w3.org/2001/XMLSchema#string