FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. - Wikidata - awgldk - TriplyDB

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.

http://www.wikidata.org/entity/Q34448805

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N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions Recent advances in dynamic m6A RNA modification Translating the epitranscriptome Role of FTO in Adipocyte Development and Function: Recent Insights Impacts of Alternative Splicing Events on the Differentiation of Adipocytes Dynamics of Human and Viral RNA Methylation during Zika Virus Infection Messenger RNA modifications: Form, distribution, and function HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing Events Cytoplasmic m6A reader YTHDF3 promotes mRNA translation.YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA.Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis.Transcriptome-wide N 6 -methyladenosine methylome profiling of porcine muscle and adipose tissues reveals a potential mechanism for transcriptional regulation and differential methylation pattern Complex Relationship between Obesity and the Fat Mass and Obesity Locus m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover.Reversible methylation of m6Am in the 5' cap controls mRNA stability.FTO influences adipogenesis by regulating mitotic clonal expansion The Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation.N6-methyladenosine modification in mRNA: machinery, function and implications for health and diseases.N(6)-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells.N6-adenosine methylation in MiRNAs.RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation Tissue Distribution of Porcine FTO and Its Effect on Porcine Intramuscular Preadipocytes Proliferation and Differentiation.Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases.RNA epigenetics--chemical messages for posttranscriptional gene regulation.The Fto Gene Regulates the Proliferation and Differentiation of Pre-Adipocytes in Vitro Increased N6-methyladenosine in Human Sperm RNA as a Risk Factor for Asthenozoospermia.N(6)-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5.Mouse Maternal High-Fat Intake Dynamically Programmed mRNA m⁶A Modifications in Adipose and Skeletal Muscle Tissues in Offspring.Immune Regulator MCPIP1 Modulates TET Expression during Early Neocortical Development.Deciphering the epitranscriptome: A green perspective.Fto-Deficiency Affects the Gene and MicroRNA Expression Involved in Brown Adipogenesis and Browning of White Adipose Tissue in Mice.Post-transcriptional gene regulation by mRNA modifications.Distinct 5-methylcytosine profiles in poly(A) RNA from mouse embryonic stem cells and brain.AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N6-methyladenosine FTO is required for myogenesis by positively regulating mTOR-PGC-1α pathway-mediated mitochondria biogenesis.Computational analyses of type 2 diabetes-associated loci identified by genome-wide association studies.Gene regulation in the immune system by long noncoding RNAs.m6aViewer: software for the detection, analysis and visualization of N6-methyl-adenosine peaks from m6A-seq/ME-RIP sequencing data.

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P2860

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.

http://www.wikidata.org/entity/Q34448805

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2014 nî lūn-bûn

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2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2014年の論文

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Bao-Fa Sun

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Chuan He

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Chun-Min Huang

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Gui-Fang Jia

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Hyun Seok Jeong

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Jannie M Rendtlew Danielsen

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Kang-Xuan Jin

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Shu-Hui Song

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Wei Wu

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Wei-Min Tong

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P2860

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

FTO: the first gene contributing to common forms of human obesity

N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites

ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility

N6-methyladenosine-dependent regulation of messenger RNA stability

Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO

A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

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10.1038/CR.2014.151

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12

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Akimitsu Okamoto

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268788288

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