Definition of the intermediates and mechanism of the anticancer drug bleomycin using nuclear resonance vibrational spectroscopy and related methods. - Wikidata - awgldk - TriplyDB

Definition of the intermediates and mechanism of the anticancer drug bleomycin using nuclear resonance vibrational spectroscopy and related methods.

Definition of the intermediates and mechanism of the anticancer drug bleomycin using nuclear resonance vibrational spectroscopy and related methods.

http://www.wikidata.org/entity/Q34450286

about

Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic Excited state potential energy surfaces and their interactions in Fe(IV)=O active sites Experimentally quantifying small-molecule bond activation using valence-to-core X-ray emission spectroscopy Differences and comparisons of the properties and reactivities of iron(III)-hydroperoxo complexes with saturated coordination sphere Characterization of a synthetic peroxodiiron(III) protein model complex by nuclear resonance vibrational spectroscopy.Lovastatin prevents bleomycin-induced DNA damage to HepG2 cells.Spectroscopic elucidation of a new heme/copper dioxygen structure type: implications for O···O bond rupture in cytochrome c oxidase Comparison of high-spin and low-spin nonheme Fe(III)-OOH complexes in O-O bond homolysis and H-atom abstraction reactivities Nuclear resonance vibrational spectroscopic and computational study of high-valent diiron complexes relevant to enzyme intermediates.Geometric and electronic structure contributions to function in non-heme iron enzymes.The pathogenesis of bleomycin-induced lung injury in animals and its applicability to human idiopathic pulmonary fibrosis.Therapeutic opportunities within the DNA damage response.Modeling DNA damage-induced pneumopathy in mice: insight from danger signaling cascades.Mononuclear iron(iii) complexes of tridentate ligands with efficient nuclease activity and studies of their cytotoxicity.Mono- and binuclear non-heme iron chemistry from a theoretical perspective.Bleomycin-induced trans lipid formation in cell membranes and in liposome models.Nuclear Resonance Vibrational Spectroscopic Definition of Peroxy Intermediates in Nonheme Iron Sites.O2 Activation by Non-Heme Iron Enzymes.L-edge spectroscopy of dilute, radiation-sensitive systems using a transition-edge-sensor array.Anti-cancer iron(II) complexes of pentadentate N-donor ligands: cytotoxicity, transcriptomics analyses, and mechanisms of action.Exchangeable proton ENDOR as a probe of the redox-active iron center in activated bleomycin and ferric bleomycin.NRVS Studies of the Peroxide Shunt Intermediate in a Rieske Dioxygenase and Its Relation to the Native FeII O2 Reaction.

P2860

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P2860

Definition of the intermediates and mechanism of the anticancer drug bleomycin using nuclear resonance vibrational spectroscopy and related methods.

http://www.wikidata.org/entity/Q34450286

description

2010 nî lūn-bûn

@nan

2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Definition of the intermediate ...... ctroscopy and related methods.

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Definition of the intermediate ...... ctroscopy and related methods.

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PNAS.1016323107

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Proceedings of the National Academy of Sciences of the United States of America

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Definition of the intermediate ...... ctroscopy and related methods.

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P2093

Britt Hedman

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Caleb B Bell

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Jiyong Zhao

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Keith O Hodgson

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Lei V Liu

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Marina S Chow

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Samuel A Wilson

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Shaun D Wong

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Yeonju Kwak

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P2860

Solution structure of Co(III)-bleomycin-OOH bound to a phosphoglycolate lesion containing oligonucleotide: implications for bleomycin-induced double-strand DNA cleavage

Structures of HO(2)-Co(III)bleomycin A(2) bound to d(GAGCTC)(2) and d(GGAAGCTTCC)(2): structure-reactivity relationships of Co and Fe bleomycins

Crystal structure of DNA-bound Co(III){middle dot}bleomycin B2: Insights on intercalation and minor groove binding

Crystal structure of substrate-free Pseudomonas putida cytochrome P-450

Bleomycin: new perspectives on the mechanism of action.

Nuclear resonance vibrational spectroscopy applied to [Fe(OEP)(NO)]: the vibrational assignments of five-coordinate ferrous heme-nitrosyls and implications for electronic structure.

Oriented single-crystal nuclear resonance vibrational spectroscopy of [Fe(TPP)(MI)(NO)]: quantitative assessment of the trans effect of NO.

Nuclear resonance vibrational spectroscopy--NRVS.

Further insights into the mechanism of the reaction of activated bleomycin with DNA

A combined NRVS and DFT study of Fe(IV)=O model complexes: a diagnostic method for the elucidation of non-heme iron enzyme intermediates.

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22419-22424

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