Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGF receptor-mediated epithelial cell adherens junction dynamics and cell migration.
about
Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligasesVav family exchange factors: an integrated regulatory and functional viewMutant Cbl proteins as oncogenic drivers in myeloproliferative disordersUbiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cellsSHP2E76K mutant promotes lung tumorigenesis in transgenic miceNexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants.The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility.The E3 ubiquitin ligase Cbl-b improves the prognosis of RANK positive breast cancer patients by inhibiting RANKL-induced cell migration and metastasis.Cbl-b promotes cell detachment via ubiquitination of focal adhesion kinaseCasitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation.A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells.Cbl-family proteins as regulators of cytoskeleton-dependent phenomena.Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene.Loss of MLCK leads to disruption of cell-cell adhesion and invasive behavior of breast epithelial cells via increased expression of EGFR and ERK/JNK signaling.Cbl-family ubiquitin ligases and their recruitment of CIN85 are largely dispensable for epidermal growth factor receptor endocytosis.Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts.An essential role of CBL and CBL-B ubiquitin ligases in mammary stem cell maintenance.Celecoxib inactivates epithelial-mesenchymal transition stimulated by hypoxia and/or epidermal growth factor in colon cancer cells.Cdc42 induces EGF receptor protein accumulation and promotes EGF receptor nuclear transport and cellular transformation.E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning.[Expressions of c-Cbl, Cbl-b and EGFR and its role of prognosis in NSCLC].Molecular Signatures of the Insulin-like Growth Factor 1-mediated Epithelial-Mesenchymal Transition in Breast, Lung and Gastric Cancers
P2860
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P2860
Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGF receptor-mediated epithelial cell adherens junction dynamics and cell migration.
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Negative regulation of EGFR-Va ...... n dynamics and cell migration.
@ast
Negative regulation of EGFR-Va ...... n dynamics and cell migration.
@en
Negative regulation of EGFR-Va ...... n dynamics and cell migration.
@nl
type
label
Negative regulation of EGFR-Va ...... n dynamics and cell migration.
@ast
Negative regulation of EGFR-Va ...... n dynamics and cell migration.
@en
Negative regulation of EGFR-Va ...... n dynamics and cell migration.
@nl
prefLabel
Negative regulation of EGFR-Va ...... n dynamics and cell migration.
@ast
Negative regulation of EGFR-Va ...... n dynamics and cell migration.
@en
Negative regulation of EGFR-Va ...... n dynamics and cell migration.
@nl
P2093
P2860
P356
P1476
Negative regulation of EGFR-Va ...... on dynamics and cell migration
@en
P2093
Alagarsamy L Reddi
Chandrani Mukhopadhyay
Gengsheng Chen
Guoguang Ying
Hamid Band
Manjari Dimri
Mark A Rainey
Robert J Clubb
P2860
P304
P356
10.1074/JBC.M110.188086
P407
P577
2010-10-12T00:00:00Z