Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole. - Wikidata - awgldk - TriplyDB

Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole.

Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole.

http://www.wikidata.org/entity/Q34453657

about

Regulation of the centrosome cycle Naegleria: a classic model for de novo basal body assembly Building a ninefold symmetrical barrel: structural dissections of centriole assembly p53 protects against genome instability following centriole duplication failure The PLK4-STIL-SAS-6 module at the core of centriole duplication Asterless is required for centriole length control and sperm development DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6.The Centrioles, Centrosomes, Basal Bodies, and Cilia of Drosophila melanogaster.Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay STIL binding to Polo-box 3 of PLK4 regulates centriole duplication Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication.Conserved molecular interactions in centriole-to-centrosome conversion.CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis Suppression of ectopic assembly of centriole proteins ensures mitotic spindle integrity Drosophila Ana1 is required for centrosome assembly and centriole elongation.A centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk4 Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole A yeast two-hybrid approach for probing protein-protein interactions at the centrosome.Quantitative analysis of human centrosome architecture by targeted proteomics and fluorescence imaging.Ubiquitin, the centrosome, and chromosome segregation.A non-canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation.Binding of STIL to Plk4 activates kinase activity to promote centriole assembly Regulation of centriolar satellite integrity and its physiology Towards a molecular architecture of the centrosome in Toxoplasma gondii.Molecular basis of the STIL coiled coil oligomerization explains its requirement for de-novo formation of centrosomes in mammalian cells.Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles.NEK7 is required for G1 progression and procentriole formation.Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse.CEP295 interacts with microtubules and is required for centriole elongation Plk4-dependent phosphorylation of STIL is required for centriole duplication.A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies.Promotion and Suppression of Centriole Duplication Are Catalytically Coupled through PLK4 to Ensure Centriole Homeostasis.The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies.The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation.Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation.Building the right centriole for each cell type.Controlling centriole numbers: Geminin family members as master regulators of centriole amplification and multiciliogenesis.PLK4: a link between centriole biogenesis and cancer.STIL balancing primary microcephaly and cancer.Interaction between the C. elegans centriolar protein SAS-5 and microtubules facilitates organelle assembly.

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P2860

Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole.

http://www.wikidata.org/entity/Q34453657

description

2014 nî lūn-bûn

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2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2014 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Direct interaction of Plk4 wit ...... triole per parental centriole.

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Direct interaction of Plk4 wit ...... triole per parental centriole.

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Direct interaction of Plk4 wit ...... triole per parental centriole.

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Direct interaction of Plk4 wit ...... triole per parental centriole.

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P1433

Nature Communications

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Direct interaction of Plk4 wit ...... ntriole per parental centriole

@en

P2093

Daiju Kitagawa

http://www.w3.org/2001/XMLSchema#string

Hiroko Kozuka-Hata

http://www.w3.org/2001/XMLSchema#string

Masaaki Oyama

http://www.w3.org/2001/XMLSchema#string

Masaki Inagaki

http://www.w3.org/2001/XMLSchema#string

Midori Ohta

http://www.w3.org/2001/XMLSchema#string

Tomoko Ashikawa

http://www.w3.org/2001/XMLSchema#string

Yuka Nozaki

http://www.w3.org/2001/XMLSchema#string

P2860

The Polo kinase Plk4 functions in centriole duplication

The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation

STIL is required for centriole duplication in human cells

Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome

Plk4-induced centriole biogenesis in human cells

SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells

Regulated HsSAS-6 levels ensure formation of a single procentriole per centriole during the centrosome duplication cycle

Structures of SAS-6 suggest its organization in centrioles

Structural Basis of the 9-Fold Symmetry of Centrioles

The Structure of the Plk4 Cryptic Polo Box Reveals Two Tandem Polo Boxes Required for Centriole Duplication

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5267

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scholarly article

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10.1038/NCOMMS6267

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5

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25342035

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4220463

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