Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences. - Wikidata - awgldk - TriplyDB

Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences.

Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences.

http://www.wikidata.org/entity/Q34467801

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Association between KCNJ6 (GIRK2) gene polymorphisms and postoperative analgesic requirements after major abdominal surgery Essential role for RGS9 in opiate action Behavioral and Genetic Evidence for GIRK Channels in the CNS: Role in Physiology, Pathophysiology, and Drug Addiction Kir3 channel signaling complexes: focus on opioid receptor signaling Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury Activation of a Gq-coupled membrane estrogen receptor rapidly attenuates α2-adrenoceptor-induced antinociception via an ERK I/II-dependent, non-genomic mechanism in the female rat beta-Arrestin2, interacting with phosphodiesterase 4, regulates synaptic release probability and presynaptic inhibition by opioids.The neuroanatomy of sexual dimorphism in opioid analgesia.Targeting GIRK Channels for the Development of New Therapeutic Agents.Peripheral G protein-coupled inwardly rectifying potassium channels are involved in δ-opioid receptor-mediated anti-hyperalgesia in rat masseter muscle.The antinociceptive effect of esmolol Modulation of pain transmission by G-protein-coupled receptors.Sex-specificity and estrogen-dependence of kappa opioid receptor-mediated antinociception and antihyperalgesia.A pervasive mechanism for analgesia: activation of GIRK2 channels.Potentiation of excitatory transmission in substantia gelatinosa neurons of rat spinal cord by inhibition of estrogen receptor alpha.Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease.Increased presynaptic and postsynaptic α2-adrenoceptor activity in the spinal dorsal horn in painful diabetic neuropathy.Functional selectivity and time-dependence of μ-opioid receptor desensitization at nerve terminals in the mouse ventral tegmental area Pharmacogenetics of new analgesics.Sex differences in the contribution of ATP-sensitive K+ channels in trigeminal ganglia under an acute muscle pain condition GIRK Channels Modulate Opioid-Induced Motor Activity in a Cell Type- and Subunit-Dependent Manner Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to human Differential ascending projections of temporomandibular joint-responsive brainstem neurons to periaqueductal gray and posterior thalamus of male and female rats.G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy GIRK channel modulation by assembly with allosterically regulated RGS proteins Deletion of GIRK2 Subunit of GIRK Channels Alters the 5-HT1A Receptor-Mediated Signaling and Results in a Depression-Resistant Behavior Alcohol dependence as a chronic pain disorder Pharmacogenetics of chronic pain and its treatment.Sex-specific modulation of spinal nociception by alpha2-adrenoceptors: differential regulation by estrogen and testosterone.Dexmedetomidine and ST-91 analgesia in the formalin model is mediated by alpha2A-adrenoceptors: a mechanism of action distinct from morphine Molecular Pharmacology of δ-Opioid Receptors.Knockout of spinophilin, an endogenous antagonist of arrestin-dependent alpha2-adrenoceptor functions, enhances receptor-mediated antinociception yet does not eliminate sex-related differences.Estrogen-dependent, sex-specific modulation of mustard oil-induced secondary thermal hyperalgesia by orphanin FQ in the rat Sex, gender, and pain: an overview of a complex field.Absence and rescue of morphine withdrawal in GIRK/Kir3 knock-out mice.Gender differences and pain medication.Gi-DREADD Expression in Peripheral Nerves Produces Ligand-Dependent Analgesia, as well as Ligand-Independent Functional Changes in Sensory Neurons G protein-gated inwardly rectifying potassium (KIR3) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites.Activation of membrane estrogen receptors attenuates opioid receptor-like1 receptor-mediated antinociception via an ERK-dependent non-genomic mechanism Sex differences in μ-opioid receptor expression in trigeminal ganglia under a myositis condition in rats.

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Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences.

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Contribution of GIRK2-mediated ...... and analgesic sex differences.

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Proceedings of the National Academy of Sciences of the United States of America

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Contribution of GIRK2-mediated ...... and analgesic sex differences.

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Allan I Basbaum

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Igor Mitrovic

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Lily Y Jan

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Markus Stoffel

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Marta Margeta-Mitrovic

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Semon Bader

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P2860

Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2

Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures

Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3

Signalling via the G protein-activated K+ channels

Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers

Sex differences in thermal nociception and morphine antinociception in rodents depend on genotype.

G-protein mediated gating of inward-rectifier K+ channels.

Gender differences in opioid-mediated analgesia: animal and human studies.

A pervasive mechanism for analgesia: activation of GIRK2 channels.

Mu and kappa opioids inhibit transmitter release by different mechanisms.

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12496346

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