Discovery of orally active anticancer candidate CFI-400945 derived from biologically promising spirooxindoles: success and challenges.
about
Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an updateDiscovery of Novel Isatin-Based p53 InducersStructurally novel steroidal spirooxindole by241 potently inhibits tumor growth mainly through ROS-mediated mechanismsA functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain.Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts.PLK4: a link between centriole biogenesis and cancer.Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers.Highly enantioselective synthesis of spirocyclopropyloxindoles via a Rh(ii)-catalyzed asymmetric cyclopropanation reaction.DABCO-catalyzed unusual [4 + 2] cycloaddition reaction: non-substituted allenoate acts as a four-carbon synthon and facile synthesis of spirooxindoles.Methyl isocyanide as a convertible functional group for the synthesis of spirocyclic oxindole γ-lactams via post-Ugi-4CR/transamidation/cyclization in a one-pot, three-step sequence.
P2860
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P2860
Discovery of orally active anticancer candidate CFI-400945 derived from biologically promising spirooxindoles: success and challenges.
description
2015 nî lūn-bûn
@nan
2015 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի մարտին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Discovery of orally active ant ...... doles: success and challenges.
@ast
Discovery of orally active ant ...... doles: success and challenges.
@en
Discovery of orally active ant ...... doles: success and challenges.
@nl
type
label
Discovery of orally active ant ...... doles: success and challenges.
@ast
Discovery of orally active ant ...... doles: success and challenges.
@en
Discovery of orally active ant ...... doles: success and challenges.
@nl
prefLabel
Discovery of orally active ant ...... doles: success and challenges.
@ast
Discovery of orally active ant ...... doles: success and challenges.
@en
Discovery of orally active ant ...... doles: success and challenges.
@nl
P2093
P1476
Discovery of orally active ant ...... doles: success and challenges.
@en
P2093
De-Quan Yu
Hong-Min Liu
Ping-Ping Qi
Zhiqiang Yu
P356
10.1016/J.EJMECH.2015.03.020
P577
2015-03-12T00:00:00Z