HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. - Wikidata - awgldk - TriplyDB

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

http://www.wikidata.org/entity/Q34471121

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Primordial germ cells in mice HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1 Role of nuclear receptors in breast cancer stem cells Glioma Stem Cells and Their Microenvironments: Providers of Challenging Therapeutic Targets Energy Metabolism Plays a Critical Role in Stem Cell Maintenance and Differentiation Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance Targeting CSCs in tumor microenvironment: the potential role of ROS-associated miRNAs in tumor aggressiveness To breathe or not to breathe: the haematopoietic stem/progenitor cells dilemma The three-layer concentric model of glioblastoma: cancer stem cells, microenvironmental regulation, and therapeutic implications Chromatin features and the epigenetic regulation of pluripotency states in ESCs Nutrient-sensing pathways and metabolic regulation in stem cells HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression EMT and stem cell-like properties associated with HIF-2α are involved in arsenite-induced transformation of human bronchial epithelial cells Cancer stem cells in basic science and in translational oncology: can we translate into clinical application?Cellular and molecular mechanisms underlying oxygen-dependent radiosensitivity Epithelial-mesenchymal transition and cancer stemness: the Twist1-Bmi1 connection Hypoxia-inducible factors in the kidney miR-210: More than a silent player in hypoxia Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells Redox homeostasis: the linchpin in stem cell self-renewal and differentiation DHP-derivative and low oxygen tension effectively induces human adipose stromal cell reprogramming Acute postnatal ablation of Hif-2alpha results in anemia Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress Analytic Models of Oxygen and Nutrient Diffusion, Metabolism Dynamics, and Architecture Optimization in Three-Dimensional Tissue Constructs with Applications and Insights in Cerebral Organoids Developmentally arrested structures preceding cerebellar tumors in von Hippel-Lindau disease Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduces hypoxia in tumors Self-organization of the human embryo in the absence of maternal tissues.Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD.Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia.Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth.FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status.Hypoxia-inducible factors have distinct and stage-specific roles during reprogramming of human cells to pluripotency.HIF1/2α mediates hypoxia-induced LDHA expression in human pancreatic cancer cells Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha.Hypoxic tumor microenvironment and cancer cell differentiation.

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HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

http://www.wikidata.org/entity/Q34471121

description

2006 nî lūn-bûn

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2006 թուականի Մարտին հրատարակուած գիտական յօդուած

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2006 թվականի մարտին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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HIF-2alpha regulates Oct-4: ef ...... development, and tumor growth.

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HIF-2alpha regulates Oct-4: ef ...... development, and tumor growth.

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HIF-2alpha regulates Oct-4: ef ...... development, and tumor growth.

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HIF-2alpha regulates Oct-4: ef ...... development, and tumor growth.

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HIF-2alpha regulates Oct-4: ef ...... development, and tumor growth.

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HIF-2alpha regulates Oct-4: ef ...... development, and tumor growth.

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HIF-2alpha regulates Oct-4: ef ...... development, and tumor growth.

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HIF-2alpha regulates Oct-4: ef ...... development, and tumor growth.

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HIF-2alpha regulates Oct-4: ef ...... development, and tumor growth.

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Genes & Development

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HIF-2alpha regulates Oct-4: ef ...... development, and tumor growth

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Andrew M Arsham

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Brian Keith

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Hongwei Yu

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James Kehler

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John D Gordan

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Kelly L Covello

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M Celeste Simon

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Patricia A Labosky

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P2860

Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

Core transcriptional regulatory circuitry in human embryonic stem cells

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

HIF-1 and human disease: one highly involved factor

Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

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557-570

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10.1101/GAD.1399906

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5

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20

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16510872

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