Human CST has independent functions during telomere duplex replication and C-strand fill-in
about
HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitmentStructure and function of the telomeric CST complexShort telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancyLength-dependent processing of telomeres in the absence of telomerase.Cell biology of disease: Telomeropathies: an emerging spectrum disorderFission yeast Stn1 is crucial for semi-conservative replication at telomeres and subtelomeres.Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands.CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance.Telomere Biology-Insights into an Intriguing Phenomenon.SUMOylation regulates telomere length by targeting the shelterin subunit Tpz1(Tpp1) to modulate shelterin-Stn1 interaction in fission yeast.Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactionsTelomere stability and development of ctc1 mutants are rescued by inhibition of EJ recombination pathways in a telomerase-dependent manner.TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.Human cells lacking coilin and Cajal bodies are proficient in telomerase assembly, trafficking and telomere maintenance.The role of double-strand break repair pathways at functional and dysfunctional telomeres.Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association.Role of STN1 and DNA polymerase α in telomere stability and genome-wide replication in Arabidopsis.POT1a and components of CST engage telomerase and regulate its activity in Arabidopsis.Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr93 phosphorylation and telomerase recruitment.The CDC13-STN1-TEN1 complex stimulates Pol α activity by promoting RNA priming and primase-to-polymerase switch.Stn1 is critical for telomere maintenance and long-term viability of somatic human cells.Identification of Genes That Modulate Susceptibility to Formaldehyde and Imatinib by Functional Genomic Screening in Human Haploid KBM7 Cells.A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plusSTN1 OB Fold Mutation Alters DNA Binding and Affects Selective Aspects of CST Function.Human CST abundance determines recovery from diverse forms of DNA damage and replication stress.Hypothesis: Paralog Formation from Progenitor Proteins and Paralog Mutagenesis Spur the Rapid Evolution of Telomere Binding Proteins.Organization and Evolution of Drosophila Terminin: Similarities and Differences between Drosophila and Human Telomeres.Suppression of STN1 enhances the cytotoxicity of chemotherapeutic agents in cancer cells by elevating DNA damage.Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects.The molecular genetics of the telomere biology disorders.Signaling of double strand breaks and deprotected telomeres in ArabidopsisHuman TEN1 maintains telomere integrity and functions in genome-wide replication restartCST for the grand finale of telomere replication.Surprises from the chromosome front: lessons from Arabidopsis on telomeres and telomerase.Molecular basis of telomere syndrome caused by CTC1 mutations.The 3' overhangs at Tetrahymena thermophila telomeres are packaged by four proteins, Pot1a, Tpt1, Pat1, and Pat2.Cdk1 regulates the temporal recruitment of telomerase and Cdc13-Stn1-Ten1 complex for telomere replication.Genome destabilizing mutator alleles drive specific mutational trajectories in Saccharomyces cerevisiaeIf the cap fits, wear it: an overview of telomeric structures over evolution.Telomere-end processing: mechanisms and regulation.
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P2860
Human CST has independent functions during telomere duplex replication and C-strand fill-in
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Human CST has independent func ...... plication and C-strand fill-in
@ast
Human CST has independent func ...... plication and C-strand fill-in
@en
Human CST has independent func ...... plication and C-strand fill-in
@nl
type
label
Human CST has independent func ...... plication and C-strand fill-in
@ast
Human CST has independent func ...... plication and C-strand fill-in
@en
Human CST has independent func ...... plication and C-strand fill-in
@nl
prefLabel
Human CST has independent func ...... plication and C-strand fill-in
@ast
Human CST has independent func ...... plication and C-strand fill-in
@en
Human CST has independent func ...... plication and C-strand fill-in
@nl
P2093
P2860
P1433
P1476
Human CST has independent func ...... plication and C-strand fill-in
@en
P2093
Carolyn M Price
Christopher Kasbek
Jason A Stewart
P2860
P304
P356
10.1016/J.CELREP.2012.10.007
P577
2012-11-08T00:00:00Z